Results 81 to 90 of about 208,461 (352)

Differential trends in the rising incidence of endometrial cancer by type: data from a UK population-based registry from 1994 to 2006 [PDF]

, 2011
BACKGROUND: Endometrial cancer is the most common gynaecological cancer in the western world, the incidence increasing in the United Kingdom by over 40 % since 1993.
A Blann, A Doll, A Jemal, A Mendivil, AG Renehan, D Llobet, F Amant, F Bray, G Gatta, GK Reeves, HC Kitchener, J Ferlay, JP Archie Jr, JV Bokhman, K Lindemann, K Lindemann, MP Coleman, N Bansal, N Cooper, O Sany, P Pearmain, P Singh, PW Dickman, R De Angelis, R Ganesan, S Friel, S Sundar, SM Ueda, T Bjorge, T Evans   +29 more
core   +2 more sources

Management of Endometrial Cancer

International Journal of Translation & Community Medicine, 2013
Endometrial cancer (EC) is the most common malignancy of the female genital tract.1 It occurs primarily in postmenopausal women. Overall, about 2.64% of women develop EC during their lifetime. In those patients, the most common presenting symptom is abnormal uterine bleeding. Based on clinical and pathological features, sporadic EC is classified into 2
Androutsopoulos G, Decavalas G
openaire   +1 more source

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

Molecular Oncology, EarlyView.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang, Hei Ip Hong, Victor C. Y. Mak, Yuan Zhou, Yiling Lu, Guanglei Zhuang, Lydia W. T. Cheung   +6 more
wiley   +1 more source

Systemic circulating microRNA landscape in Lynch syndrome

International Journal of Cancer, Volume 152, Issue 5, Page 932-944, 1 March 2023., 2023
What's new? Systemic circulating microRNA expression patterns (c‐miRnomes) are altered during sporadic carcinogenesis and they have predictive potential in early cancer detection. However, their potential in carriers of inherited pathogenic mismatch‐repair gene variants associated with Lynch syndrome remains understudied.
Tero Sievänen, Tia‐Marje Korhonen, Tiina Jokela, Maarit Ahtiainen, Laura Lahtinen, Teijo Kuopio, Anna Lepistö, Elina Sillanpää, Jukka‐Pekka Mecklin, Toni T. Seppälä, Eija K. Laakkonen   +10 more
wiley   +1 more source

The Impact of Missing Data on Causal Discovery: A Multicentric Clinical Study [PDF]

arXiv, 2023
Causal inference for testing clinical hypotheses from observational data presents many difficulties because the underlying data-generating model and the associated causal graph are not usually available. Furthermore, observational data may contain missing values, which impact the recovery of the causal graph by causal discovery algorithms: a crucial ...
arxiv  

EMP2 regulates angiogenesis in endometrial cancer cells through induction of VEGF. [PDF]

, 2013
Understanding tumor-induced angiogenesis is a challenging problem with important consequences for the diagnosis and treatment of cancer. In this study, we define a novel function for epithelial membrane protein-2 (EMP2) in the control of angiogenesis ...
Braun, J, Chan, A, Dhawan, P, Fu, M, Goodglick, L, Gordon, LK, Kiyohara, M, Wadehra, M   +7 more
core  

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Clinical Value Evaluation of SKA3 in Endometrial Cancer and Its Promotion of Proliferation and Migration of Endometrial Cancer Cells

Clinical and Experimental Obstetrics & Gynecology
Background: Endometrial cancer is one of the common cancers in gynecology, which seriously endangers women’s reproductive health. Therefore, it is urgent to search for new diagnostic and prognostic monitoring markers for endometrial ...
Xiaoxing Ding, Yue Zhang, Jiayun Qin, Yu Zhang, Jinwei Zhang   +4 more
doaj   +1 more source

Linking type 2 diabetes and gynecological cancer: An introductory overview [PDF]

, 2018
Type 2 diabetes (T2D) is a chronic disease with a growing prevalence and a leading cause of death in many countries. Several epidemiological studies observed an association between T2D and increased risk of many types of cancer, such as gynecologic ...
Anastasi, Emanuela, Angeloni, Antonio, Filardi, Tiziana, Lenzi, Andrea, Morano, Susanna, Tartaglione, Sara   +5 more
core   +1 more source

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source