Results 81 to 90 of about 4,742,503 (345)

Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding : systematic review and meta-analysis of data from individual patients [PDF]

, 2010
Peer reviewedPublisher ...
J. P. Daniels, K. G. Cooper, K. S. Khan, L. J. Middleton, M. Gannon, N. H. Hilken, null null, P. O'Donovan, R. Champaneria, R. Gray, S. Bhattacharya   +10 more
core   +2 more sources

Exosomal miR-499a-5p Inhibits Endometrial Cancer Growth and Metastasis via Targeting VAV3

Cancer Management and Research, 2020
Background/Aim The current therapeutic strategies for endometrial cancer are limited and unsatisfactory. Accumulating evidence suggest that microRNAs (miRNAs) participate in tumor growth and metastasis.
L. Jing, X. Hua, Yuanna Du, Zang Rukun, Junjun Mou   +4 more
semanticscholar   +1 more source

Insulin and Endometrial Cancer [PDF]

American Journal of Epidemiology, 1997
Elevated insulin levels may explain part of the increased risk of endometrial cancer observed in obese postmenopausal women. Circulating sex hormones and fasting C-peptide levels were measured in sera obtained from 165 postmenopausal endometrial cancer cases accrued between June 1, 1987, and May 15, 1990, from hospitals in Chicago, Illinois; Hershey ...
Louise A. Brinton, Rebecca Troisi, Robert N. Hoover, Nancy Potischman, Pentti K. Siiteri   +4 more
openaire   +2 more sources

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

Fertility preservation in gynaecologic cancers [PDF]

, 2018
Due to substantial improvement in the diagnosis and treatment of gynaecologic cancers, a better understanding of patient care needs to be revised. We reviewed the literature related to fertility preservation strategies in gynaecological cancer and ...
De Felice, Francesca, Di Pinto, Anna, Marchetti, Claudia, Musella, Angela, Muzii, Ludovico, Palaia, Innocenza, Panici, Pierluigi Benedetti, Porpora, Maria Grazia, Tomao, Federica, Tombolini, Vincenzo   +9 more
core   +1 more source

The Role of Hyperglycemia in Endometrial Cancer Pathogenesis

Cancers, 2020
Endometrial cancer is one of the most common cancers in women worldwide and its incidence is increasing. Epidemiological evidence shows a strong association between endometrial cancer and obesity, and multiple mechanisms linking obesity and cancer ...
F. Byrne, Amy R. Martin, Melidya Kosasih, Beth T Caruana, R. Farrell   +4 more
semanticscholar   +1 more source

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

Advanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing（WGS） and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang, Zhaoxu Wu, Qiang Ju, Nuo Xu, Xian Chen, Hongguang Chen, Shuaishuai Yang, Jing Ji, Yanjie Zhao   +8 more
wiley   +1 more source

Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer

Cancer immunology research, 2020
Risk stratification in endometrial cancer (EC) incorporates molecular factors but not tumor-infiltrating lymphocytes. In this study, machine learning–based quantification of intraepithelial CD8+ T cells improves EC risk stratification beyond molecular ...
N. Horeweg, M. de Bruyn, R. Nout, E. Stelloo, Katarzyna Kedziersza, A. Léon-Castillo, A. Plat, K. Mertz, M. Osse, I. Jürgenliemk-Schulz, L. Lutgens, J. Jobsen, E. M. van der Steen-Banasik, V. Smit, C. Creutzberg, T. Bosse, H. Nijman, V. Koelzer, D. Church   +18 more
semanticscholar   +1 more source

Phosphorylation‐Dependent Stabilization of Collaborator of ARF (CARF) Suppresses Lymphoma Cell Proliferation

Advanced Science, EarlyView.
This study revealed that oncogene Collaborator of ARF (CARF) is closely related to B‐cell lymphoma tumorigenesis, and shares a conserved mechanism regulating protein stability with Arabidopsis Kip‐Related Protein6 (KRP6) through casein kinase 1‐mediated phosphorylation. Reduced phosphorylation led to the enhanced protein stability of CARF, resulting in
Li Qu, Zhuang Wei, Shuting Zhou, Xiaofan Zhang, Wenjun Zhang, Aibin Liang, Zhe Wang, Hongwei Xue   +7 more
wiley   +1 more source

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source