Results 61 to 70 of about 83,626 (295)

Sarcoma do Estroma Endometrial (SEE). Factores de prognóstico clínicos e patológicos.

Acta Médica Portuguesa, 1997
Endometrial Stromal Sarcomas are rare neoplasms, accounting for 0.2% of female genital tract malignancies. They occur predominantly in post menopausal women, although they can develop during the reproductive years or even in childhood. The most important
I Paiva, C Ramalho, A L Paiva, R Mesquita, J M Moutinho, A Alves, O Bacelar, M P Ferreira, L Cerejeira   +8 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

The Role of Human Papilloma Virus in Synchronous Gynecologic Malignancies: A Report of Two Cases and Review of the Literature

Gynecology Obstetrics & Reproductive Medicine, 2015
Aim of the paper is to investigate the suspicious role of HPV in synchronous endometrial and cervical carcinomas and to discuss the relation between HPV and endometrium epithelium.
Salih Taşkın, Emre Göksan Pabuçcu, Alper Kahraman, İbrahim Yalçın, Uğur Fırat Ortaç   +4 more
doaj  

Three-dimensional virtual histology of benign and malignant endometrial stromal neoplasms: a new perspective on why morphology matters [PDF]

, 2021
F. Kommoss, Jonas Albers, Constantin Schwab, Willi L. Wagner, Giuliana Tromba, Christian Dullin   +5 more
openalex   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Znaczenie polimorfizmu pojedynczych nukleotydów Arg399Gln genu XRCC1 w raku endometrium u polskich kobiet w wieku pomenopauzalnym

Menopause Review, 2011
Background: Endometrial cancer is one of the most common malignant neoplasms which appear in the uterine body. X-ray repair cross-complementing 1 (XRCC1) protein can be involved in the repair of DNA lesions, which are known to contribute to endometrial ...
Hanna Romanowicz-Makowska, Beata Smolarz, Amer Houli, Bożena Góralczyk, Ireneusz Połać, Krzysztof Szyłło   +5 more
doaj  

A rare case report of uterine carcinosarcoma with bilateral ovarian Brenner tumors

Frontiers in Oncology
BackgroundUterine carcinosarcoma is a rare, highly aggressive malignancy characterized by both carcinomatous and sarcomatous components. Brenner tumors of the ovary are uncommon epithelial neoplasms, usually benign but occasionally coexisting with other ...
Xinyao Wan, Fangfang Bi, Bing Xin, Chong Qiao   +3 more
doaj   +1 more source

Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer

Tumor Biology, 2018
Paraoxonase 1 plays an important role in protection from oxidative stress and also decomposes homocysteine thiolactone, the toxic metabolite of homocysteine.
Krzysztof Gałczyński, Jerzy Bełtowski, Łukasz Nowakowski, Danuta Vasilevska, Tomasz Rechberger, Andrzej Semczuk   +5 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Determining the Oestrogen and Progesterone Receptor Expression in Cases of Endometrial Carcinoma: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Endometrial carcinoma is the second most common female genital tract malignancy in India with a incidence rising globally. Hormone receptors are positive in 35-90% of endometrial carcinomas.
Resmi Rajeev, Nisha m das, CR jyothi
doaj   +1 more source