Results 51 to 60 of about 105,333 (202)

Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity

Frontiers in Endocrinology
Patients with adenomyosis not only experience a decrease in quality of life as a result of dysmenorrhea and severe monthly flow but they are also rendered infertile.
Yuanquan Dai, Zheng Yuan, Weisen Fan, Zhiheng Lin   +3 more
doaj   +1 more source

Exosomes derived from placental trophoblast cells regulate endometrial epithelial receptivity in dairy cows during pregnancy

The Journal of Reproduction and Development, 2021
Inadequate fetomaternal interactions could directly lead to pregnancy failure in dairy cows. Exosomes are widely involved in endometrial matrix remodeling, immune function changes, placental development, and other processes of embryo implantation and ...
Yue SU, Qianru LI, Qiaochu ZHANG, Zhiming LI, Xinxin YAO, Yong GUO, Longfei XIAO, Xiangguo WANG, Hemin NI   +8 more
doaj   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Molecular and biological markers for assessing endometrial receptivity in infertile women: A narrative review

Journal of International Medical Research
Successful embryo implantation relies on embryo quality, endometrial receptivity, and the synchronized development of both. In recent years, methods for assessing endometrial receptivity have considerably advanced, shifting from traditional imaging ...
Junfeng Li, Hange Liu, Justin Lim, Hang Xing, Yuan Chen, Shaozhe Yang, Xiuhong Fu   +6 more
doaj   +1 more source

The Role of High Cxcl11 Expression in Ovarian Dysfunction Through NF‐κB and AKT Pathways in a Thin Endometrium Mouse Model

iNew Medicine, EarlyView.
Thin endometrium upregulates Cxcl11, which polarizes ovarian macrophages via NF‐κB/AKT, impairing ovarian function. A new uter‐ovarian signaling axis is identified. ABSTRACT Objective Thin endometrium (TE) is a recognized cause of female infertility, primarily associated with impaired uterine receptivity.
Yulu Yang, Fei Tang, Zihan Meng, Yunxi Bao, Jujun Han, Xiaohua Jiang, Jianye Wang, Ying Wang, Zhaolian Wei   +8 more
wiley   +1 more source

Modern methods of influence at endometrial receptivity in patients with recurrent implantation failure (review) [PDF]

Гинекология, 2018
Objective. To carry out an analysis of the data available in scientific literature on modern methods of influence at endometrial receptivity in patients with recurrent implantation failure. Materials and methods.
M I Polovneva, I E Korneeva, O V Bourmenskaya   +2 more
doaj   +1 more source

Exploring vaginal microbiota–tissue resident stem cell crosstalk: VCAM1/Akt signaling ‐mediated enhancement of regenerative capacity

Interdisciplinary Medicine, EarlyView.
Vaginal microbiota‐derived secretory factors enhance the regenerative capacity of human endometrial stem cells by upregulating VCAM1 and activating PI3K/Akt signaling. This microbiota–stem cell crosstalk promotes self‐renewal, migration, multilineage differentiation, and metabolic reprogramming in vitro and in vivo, establishing a novel microbiota ...
Soo‐Rim Kim, Eun‐Kyung Min, Choon‐Mi Lee, Kun‐Hee Na, Chan Hum Park, YunJae Jung, Hwa‐Yong Lee   +6 more
wiley   +1 more source

Clinical aspects of embryo implantation: from the perspective of tissue perfusion. [PDF]

, 2006
Hypothesis: Pelvic perfusion is the pivotal factor for the outcome of in vitro fertilisation (IVF) treatment once clinical and embryological variables are controlled for their effect.;Demonstration of Hypothesis: In a series of three studies, the ...
Ozturk, O., Ozturk, Ozkan
core  

A Review of the Molecular Basis for Reduced Endometrial Receptivity in Uterine Fibroids and Polyps

, 2017
The presence of fibroids and endometrial polyps is associated with reduced endometrial receptivity and subsequent fertility outcomes. The following review explores the molecular mechanisms behind reduced endometrial receptivity, with a focus upon homebox
Amani Harris, Shagun Narula, Jim Tsaltas
core   +1 more source