Results 191 to 200 of about 4,542,677 (277)

Ghrelin's potential as a therapeutic target for chronic inflammatory diseases: evidence from human endometrial stromal cells. [PDF]

Front Endocrinol (Lausanne)
Dong W, Mu H, Jia F, Wei Y, Lv J, Zhou S, Yu S, Liang T.   +7 more
europepmc   +1 more source

KRAS Mutations in Cancers: From Undruggable Dilemma to Precision Medicine

MedComm, Volume 7, Issue 10, October 2026.
KRAS‐mutant cancers are therapeutically shaped by both allele identity and tumor context. Direct KRAS inhibition has achieved the greatest clinical success in KRAS G12C‐mutant NSCLC, whereas colorectal cancer often requires EGFR cotargeting and pancreatic cancer remains constrained by stromal and metabolic barriers. Shared resistance mechanisms include
Jiaying Cai, Yimin Wu, Xing Jia, Li Yang, Wenjun Yang, Weishan Lu, Zhiye Huang, Yang Pan, Zixuan Fei, Junnan Ru, Jiazheng Zhao, Jue Shen, Taobo Luo, Da Chen, Haihong Yu, Haihan Deng, Jian Zeng, Wenmei Jiang, Leilei Wu   +18 more
wiley   +1 more source

Differences between mitotically old and young endometrial tumors

The Journal of Pathology, Volume 270, Issue 2, Page 163-173, October 2026.
Abstract Human tumors likely differ in their mitotic ages, reflecting how many divisions elapse between the final tumor progenitor cell and surgical removal. We used a rapidly fluctuating CpG (fCpG) methylation clock to infer relative endometrial adenocarcinomas (EAC) mitotic ages.
Kellie Kim, Darryl Shibata
wiley   +1 more source

Membrane Progesterone Receptor Beta Regulates the Decidualization of Endometrial Stromal Cells in Women with Endometriosis. [PDF]

Int J Mol Sci
Velázquez-Hernández DM, Vázquez-Martínez ER, Cruz-Orozco O, Silvestri-Tomassoni JR, Sánchez-Ramírez B, Olguín-Ortega A, Escobar-Ponce LF, Rodríguez-Dorantes M, Camacho-Arroyo I.   +8 more
europepmc   +1 more source

Efficacy and Safety of Elagolix Versus Dienogest for Treatment of Moderate‐to‐Severe Endometriosis Pain: A Phase III, Multicentric, Double‐Blind, Active‐Controlled, Non‐Inferiority Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 11, Page 2025-2034, October 2026.
ABSTRACT Objective To compare the efficacy, safety and tolerability of elagolix with dienogest in women with moderate‐to‐severe endometriosis‐associated pain. Design A multicentre, double‐blind, double‐dummy, randomised, parallel‐group, active‐controlled, non‐inferiority phase III study. Setting Nineteen clinical centres across India.
Sneha Bhoir, Jaldhara Patel, Tushar Palve, Mrinal Kanti Dash, Sweety Saigal, Gourisankar Kamilya, Shalini Srivastava, Kartikbhai Savalia, Tanusree Gupta, Deepa Choudhary, Manohar Rangaswamy, Vidya V Bhatt, Neena Gupta, Malathi Ponnuru, Parul Shah, Apurva Shetty, Shruti Saha, Reshma Quadros, Sucheta Pandit, Dipak Patil, Piyush Patel, Pravin Ghadge, Lalit Lakhwani, Suyog Mehta, Sadhana Joglekar   +24 more
wiley   +1 more source

Modeling the window of implantation: insights from endometrial biopsy and menstrual blood-derived organoids and endometrial stromal cells. [PDF]

Hum Reprod Open
Luongo FP, Ortega Baño I, Belmonte G, Gentile M, Paccagnini E, Salumets A, Piomboni P, Luddi A.   +7 more
europepmc   +1 more source

Transumbilical laparoendoscopic single‐site surgery versus conventional multi‐port laparoscopy for myomectomy: A large single‐center retrospective study

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 2068-2080, October 2026.
This retrospective observational study compared clinical outcomes from patients who underwent transumbilical laparoendoscopic single‐site surgery (single‐site laparoscopy) or conventional multi‐port laparoscopy for myomectomy. Single‐site laparoscopy and multi‐port laparoscopy showed similar performance in terms of surgical safety.
Xu Yang, Hong Liao, Hongyu Jin, Fan Yang, Sijing Chen, Yu Chen, Jianhong Liu, Xiaorong Qi, Kana Wang, Jinke Li, Qiao Wang, Ying Zheng   +11 more
wiley   +1 more source

Deciphering estrogen receptor alpha-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape. [PDF]

F S Sci
Montague Redecke SG, Bell-Hensley A, Li S, Yi M, Jain A, Massri AJ, DeMayo FJ.   +6 more
europepmc   +1 more source

Aggressive Clinical Course of Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT) Harboring GREB1::SS18 Fusion Gene: A Case Report

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 10, October 2026.
ABSTRACT We report a fatal case of malignant uterine tumor resembling ovarian sex cord tumor (UTROSCT) harboring the GREB1::SS18 fusion gene. A 64‐year‐old woman presented with a uterine tumor extending into the inferior vena cava, along with multiple hepatic and bone metastases.
Haruki Kasama, Ayumi Ito, Daichi Maeda, Aki Kido, Takashi Iizuka, Kaoru Abiko   +5 more
wiley   +1 more source

Effects of Nonablative Er-YAG Laser on Human Endometrial Stromal Cells (hESCs): A Pilot Study. [PDF]

Lasers Surg Med
Erel CT, Neccar D, Ozcivit Erkan IB, Gokmen Inan N, Guzel Meydanli E.   +4 more
europepmc   +1 more source