Results 171 to 180 of about 244,422 (325)

Three‐Dimensional Architecture of Ectopic Epithelium and Vasculature in Ovarian Endometriosis Revealed by Tissue‐Clearing Imaging

open access: yesCell Proliferation, EarlyView.
Our study employed a modified tissue‐clearing method combined with deep imaging for 3D reconstruction of ovarian endometriosis (OEM) lesions, revealing its morphological polymorphism at tissue and cellular levels. Besides, vessels preferentially clustered around the ectopic epithelium, with their distribution pattern strongly linked to the location of ...
Fanyuan Sun   +13 more
wiley   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

open access: yesEuropean Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

open access: yesThe FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou   +4 more
wiley   +1 more source

Transcriptional regulation in decidualized endometrial stromal cells

open access: yesThe Journal of Kansai Medical University, 2021
Hiromi Murata, Susumu Tanaka, H. Okada
semanticscholar   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

open access: yesJournal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag   +6 more
wiley   +1 more source

Anti‐Proliferative Effects of Resveratrol on Gingival Fibroblasts Derived From Amlodipine‐Induced Gingival Overgrowth

open access: yesJournal of Periodontal Research, EarlyView.
Resveratrol in repeated doses has been shown to suppress excessive cell proliferation without cytotoxic effects in amlodipine‐induced gingival hyperplasia, while not having a negative effect on mediators involved in tissue homeostasis in healthy cells, and at the same time, it reduces the expression of biomarkers involved in fibrosis processes ...
Bilkan Kara   +6 more
wiley   +1 more source

Life Course Trajectories of Body Mass Index and Risk of Cancer in Adulthood: Systematic Review and Meta‐Analysis

open access: yesObesity Reviews, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to identify common life‐course body mass index (BMI) trajectories (childhood/adulthood to adulthood) and their impact on risk of cancer overall and cancer at different sites in adulthood. Methods Observational studies were identified that assessed the association of BMI trajectories with
Samira Behboudi‐Gandevani   +6 more
wiley   +1 more source

Morphology of human endometrial explants and secretion of stromal marker proteins in short- and long-term cultures [PDF]

open access: yes, 2018
Human endometrial tissue is frequently biopsied under surgical and laparoscopic procedures for the investigation of infertility, abdominal, or menstrual pain.
Altermatt, H.   +5 more
core  

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

open access: yesObesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey   +7 more
wiley   +1 more source

Bacterial Involvement in Oral Squamous Cell Carcinoma and Potentially Malignant Oral Disorders

open access: yesOral Diseases, EarlyView.
ABSTRACT Objective To clarify the relationship between oral squamous cell carcinoma (OSCC), potentially malignant oral disease (OPMD), and bacterial flora using metagenomic analysis. Methods This cross‐sectional observational study included 50 patients in the control group and 77 patients with OPMDs, 41 with early OSCCs, and 20 with advanced OSCCs ...
Atsumu Koketsu   +16 more
wiley   +1 more source

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