Results 181 to 190 of about 145,931 (267)

Composite SMG5-SMG6 PIN domain formation is essential for NMD. [PDF]

Nat Commun
Kurscheidt K, Theunissen S, Pasquali N, Becker K, Boehm V, Conti E, Gehring NH.   +6 more
europepmc   +1 more source

Wild Animal Suffering Is Not Intractable: A Precautionary Approach to Compassionate Intervention

Journal of Applied Philosophy, Volume 43, Issue 2, Page 471-490, May 2026.
ABSTRACT Wild animals suffer due to human activity, yet natural factors contribute far more significantly to their suffering. In light of this, some propose that we have a pro tanto obligation to intervene in ecosystems to improve wild animal welfare.
Tristan Katz
wiley   +1 more source

Simultaneous inhibition of bacterial virulence and anti-phage defense systems by synergistic bacteriophage counter-defense proteins. [PDF]

EMBO J
Zhao J, Zhu Y, Wang C, Tian F, Deng J, Liao J, Zhong Z, Liu J, Guo N, Le S, Liang H.   +10 more
europepmc   +1 more source

Hydrophobic interactions of a substrate with L193 on the flexible substrate‐binding loop contribute to 3α‐hydroxysteroid dehydrogenase/carbonyl reductase catalytic efficiency

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Flexible loops within enzyme active sites are central to substrate binding, transition‐state stabilization, and catalytic turnover. Hydrophobic interactions modulate ligand recognition and influence protein function. Here, we interrogated loop‐mediated hydrophobic contributions to catalysis in 3α‐hydroxysteroid dehydrogenase/carbonyl reductase
Yan‐Liang Chen, Yun‐Hao Chou, Hwei‐Jen Lee, Tzu‐Pin Wang, Chi‐Ching Hwang   +4 more
wiley   +1 more source

Novel GH115 xylan α‐1,2‐glucuronidases with distinct preferences for xylan‐derived oligomers and polymers

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Natural polymers are promising sustainable materials for diverse applications. Xylans, major components of hemicellulose, exhibit origin‐dependent substitution patterns that determine their physicochemical properties. Targeted enzymatic modification of these substituents offers a mild and precise approach for tailoring the polymer's ...
Savvina Leontakianakou, Simone Balzer Le, Anders Sundin, Andrius Jasilionis, Giang‐Son Nguyen, Anna Nordborg, Lalitha D. Gottumukkala, Carl Grey, Anna Sofia Lewin, Eva Nordberg Karlsson   +9 more
wiley   +1 more source

Mutations altering the DNA binding domains of the human RAD52 protein exert distinct effects on homologous recombination repair in Saccharomyces cerevisiae. [PDF]

G3 (Bethesda)
Manthey GM, Wolf EW, Xu J, Negritto MC, Bouley RA, Petreaca RC, Bailis AM.   +6 more
europepmc   +1 more source

Genome‐Scale Engineering Importing Property of Escherichia coli for Improving Production of 3‐Hydroxypropionic Acid

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
We developed a systematic workflow to identify genes responsible for 3‐HP import by combining a genomic library with a fluorescent biosensor. Deleting the identified import‐related genes reduced product re‐uptake, successfully increasing 3‐HP titers by 21% and providing a new strategy for optimising microbial production platforms.
Seungjin Kim, Junyeong Sung, Ga Yeon Lim, Gyoo Yeol Jung, Hyun Gyu Lim   +4 more
wiley   +1 more source

CRISPR/Cas9-mediated TOP1 knockout in chicken DF-1 cells reveals its critical role in apoptosis regulation and genomic stability. [PDF]

J Anim Sci
Lv X, Wei Q, Zhi Q, Liu X, Li F, Niu Y, Sun H, Jin K, Chen GH, Li B, Zuo Q.   +10 more
europepmc   +1 more source

Transition From Land to Sea: Comparative Genomics Illuminates the Adaptive Evolution of the Intertidal Spider

Molecular Ecology Resources, Volume 26, Issue 4, May 2026.
ABSTRACT Spiders are renowned for their ecological versatility and silk‐based innovations in materials science, yet marine environments remain virtually uncolonized by this predominantly terrestrial lineage. A striking exception is the obligate intertidal spider genus Desis, whose members have evolved extraordinary physiological and behavioural ...
Fan Li, Yunyun Lv, Chao Bian, Quentin Moana Perrin, Yubo Zhang, Yixiao Wang, Lei Cao, Long Yu, Shengtao Guo, Wei Zhang, Qiong Shi, Daiqin Li   +11 more
wiley   +1 more source

Endonuclease V activated Pyrococcus furiosus Argonaute for the detection of food contaminated bacteria. [PDF]

NPJ Sci Food
Shi Y, Gao P, Wu D, Wu Y, Li G.
europepmc   +1 more source