Results 191 to 200 of about 271,229 (377)

Integrated simian virus 40 sequences in transformed cell DNA: analysis using restriction endonucleases.

, 1976
Gary Ketner, Thomas J. Kelly
openalex   +1 more source

The cleavage site of the restriction endonuclease Ava II [PDF]

, 1978
J. Gregor Sutcliffe, George M. Church
openalex   +1 more source

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Nature Biotechnology, 2014
Xuebing Wu, David A. Scott, Andrea J. Kriz, Anthony C Chiu, P. Hsu, D. Dadon, A. Cheng, Alexandro E. Trevino, S. Konermann, Sidi Chen, R. Jaenisch, Feng Zhang, P. Sharp   +12 more
semanticscholar   +1 more source

Death by endonuclease [PDF]

Genome Biology, 2001
openaire   +2 more sources

The Redox Activity of Protein Disulphide Isomerase Functions in Non‐Homologous End‐Joining Repair to Prevent DNA Damage

Aging Cell, EarlyView.
Schematic diagram illustrating the protective role of protein disulphide isomerase (PDI) against DNA damage via non‐homologous end‐joining (NHEJ), which repairs double stranded DNA breaks (DSBs). Induction of DNA damage results in the formation of γH2AX and p53‐binding protein 1 foci during NHEJ repair of DSBs.
Sina Shadfar, Fabiha Farzana, Sayanthooran Saravanabavan, Ashley M. Rozario, Marta Vidal, Cyril Jones Jagaraj, Sonam Parakh, Esmeralda Paric, Kristy C. Yuan, Mariana Brocardo, Donna R. Whelan, Angela S. Laird, Julie D. Atkin   +12 more
wiley   +1 more source

Analysis of Endonuclease R· Eco RI Fragments of DNA from Lambdoid Bacteriophages and Other Viruses by Agarose-Gel Electrophoresis [PDF]

, 1974
Robert B. Helling, Howard M. Goodman, Herbert W. Boyer   +2 more
openalex   +1 more source

Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?

Aging Cell, EarlyView.
Cockayne Syndrome complementation group B (CS‐B) is a highly debilitating progeroid syndrome that often culminates in the death of patients before adulthood. This review explores the pathogenesis of CS‐B and proposes that a combination of DNA damage accumulation, transcriptional dysregulation, and mitochondrial dysfunction is its underlying cause ...
Ricardo Afonso‐Reis, Cristiana R. Madeira, David V. C. Brito, Clévio Nóbrega   +3 more
wiley   +1 more source

Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Autophagy is essential for cellular homeostasis, and its impairment contributes to cardiac hypertrophy. Modulating autophagy has shown potential in treating pathological hypertrophy. Prolylcarboxypeptidase (PRCP), a lysosomal enzyme that hydrolyzes angiotensin II to Ang1‐7, has an unclear role in cardiac autophagy and hypertrophy.
Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He, Hongyuan Zhang, Bernard D. Keavney, Min Zi, Binh Y. Nguyen, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Susanne S. Hille, Elizabeth J. Cartwright, Oliver J. Müller, Honglin Xu, Sam Butterworth, Xin Wang   +16 more
wiley   +1 more source

Properties of the Main Endonuclease Specific for Apurinic Sites of Escherichia coli (Endonuclease VI) [PDF]

, 1978
Françis Gossard, Walter G. Verly
openalex   +1 more source

Mitochondrial Mutation Leads to Cardiomyocyte Hypertrophy by Disruption of Mitochondria‐Associated ER Membrane

Cell Proliferation, EarlyView.
Cardiomyocytes with high m.3243A>G burden exhibited hypertrophic phenotype. Mitochondria dysfunction occurred and tended to become round in cardiomyocytes with high m.3243A>G burden. Mitochondria‐associated ER membrane (MAM) was disrupted in cardiomyocytes with high m.3243A>G burden.
Miao Yu, Min Song, Manna Zhang, Shuangshuang Chen, Baoqiang Ni, Xuechun Li, Wei Lei, Zhenya Shen, Yong Fan, Jianyi Zhang, Shijun Hu   +10 more
wiley   +1 more source