Results 21 to 30 of about 271,229 (377)

Remdesivir—Bringing Hope for COVID-19 Treatment

Scientia Pharmaceutica, 2020
At the beginning of 2020, the world was swept with a wave of a new coronavirus disease, named COVID-19 by the World Health Organization (WHO 2). The causative agent of this infection is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...
Naser F. Al-Tannak, Ladislav Novotny, Adel Alhunayan   +2 more
doaj   +1 more source

Antiviral Activity and Molecular Dynamics Simulation of Hops Compounds against Oropouche Virus (Peribunyaviridae)

Pharmaceutics, 2023
The Oropouche virus (OROV) is a member of the family Peribunyaviridae (order Bunyavirales) and the cause of a dengue-like febrile illness transmitted mainly by biting midges and mosquitoes.
Tsvetelina Mandova, Marielena Vogel Saivish, Gabriela de Lima Menezes, Katyanna Sales Bezerra, Umberto Laino Fulco, Roosevelt Alves da Silva, Fernando Batista Da Costa, Maurício Lacerda Nogueira   +7 more
doaj   +1 more source

Programmed cell death in Leishmania: biochemical evidence and role in parasite infectivity

Frontiers in Cellular and Infection Microbiology, 2012
Demonstration of features of a programmed cell death (PCD) pathway in protozoan parasites initiated a great deal of interest and debate in the field of molecular parasitology.
Sreenivas eGannavaram, Alain eDebrabant
doaj   +1 more source

sgRNA design and in vitro nucleolytic analysis of the Cas9‐RNP complex for transgene‐free genome editing of the eIF4E1 gene from Capsicum an‐ nuum L.

Indonesian Journal of Biotechnology, 2023
Chili (Capsicum annuum L.) is a highly valued vegetable, renowned for its unique taste and aroma. However, chili production faces challenges in meeting the high demand due to infections caused by pathogens such as ChiVMV (potyvirus).
Josefanny Tham, Alfred Patisenah, Tommy Octavianus Soetrisno Tjia, Santiago Signorelli, Intan Taufik, Karlia Meitha   +5 more
doaj   +1 more source

An Argonaute from Thermus parvatiensis exhibits endonuclease activity mediated by 5′ chemically modified DNA guides

Acta Biochimica et Biophysica Sinica, 2022
Prokaryotic Argonaute (pAgo) nucleases with precise DNA cleavage activity show great potential for gene manipulation. Extensive biochemical studies have revealed that recognition of guides with different 5′ groups by Ago is important for biocatalysis ...
Sun Yingying, Guo Xiang, Lu Hui, Chen Liuqing, Huang Fei, Liu Qian, Feng Yan   +6 more
doaj   +1 more source

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway [PDF]

, 2004
In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase-independent manner, providing the correct ends for DNA synthesis coupled to the repair of the remaining 5'-dangling modified nucleotide.
Elder, RH, Gros, L, Ide, H, Ishchenko, AA, Saparbaev, MK   +4 more
core   +5 more sources

A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping and DNA sequence data. III. Cladogram estimation.

Genetics, 1992
We previously developed a cladistic approach to identify subsets of haplotypes defined by restriction endonuclease mapping or DNA sequencing that are associated with significant phenotypic deviations.
Alan R. Templeton, K. Crandall, C. Sing
semanticscholar   +1 more source

Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs

Cell Reports, 2017
Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show
Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi   +8 more
doaj   +1 more source

Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea

Frontiers in Microbiology, 2021
Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Tan Lin, Likui Zhang, Likui Zhang, Mai Wu, Donghao Jiang, Zheng Li, Zhihui Yang   +6 more
doaj   +1 more source

Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition [PDF]

, 2012
The structure-specific endonuclease activity of the human XPF–ERCC1 complex is essential for a number of DNA processing mechanisms that help to maintain genomic integrity.
Bowles, M., Fadden, A.J., Hammonds, T., Lally, J., McDonald, Neil Q., Mouilleron, S.   +5 more
core   +1 more source