Results 11 to 20 of about 145,931 (267)
Alternative end-joining in BCR gene rearrangements and translocations
Acta Biochimica et Biophysica Sinica, 2022 Programmed DNA double-strand breaks (DSBs) occur during antigen receptor gene recombination, namely V(D)J recombination in developing B lymphocytes and class switch recombination (CSR) in mature B cells.
Bai Wanyu +3 more
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Annual Review of Biochemistry, 2013 First discovered as a structure-specific endonuclease that evolved to cut at the base of single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component of cellular DNA metabolism. Substrate specificity allows FEN1 to process intermediates of Okazaki fragment maturation, long-patch base excision repair, telomere maintenance ...
Lata, Balakrishnan, Robert A, Bambara
openaire +2 more sources
Programmed cell death in Leishmania: biochemical evidence and role in parasite infectivity
Frontiers in Cellular and Infection Microbiology, 2012 Demonstration of features of a programmed cell death (PCD) pathway in protozoan parasites initiated a great deal of interest and debate in the field of molecular parasitology.
Sreenivas eGannavaram, Alain eDebrabant
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Pharmaceutics, 2023 The Oropouche virus (OROV) is a member of the family Peribunyaviridae (order Bunyavirales) and the cause of a dengue-like febrile illness transmitted mainly by biting midges and mosquitoes.
Tsvetelina Mandova +7 more
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Cell Reports, 2017 Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show
Masanori Yoshinaga +8 more
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Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease
Biomolecules, 2021 In cystic fibrosis (CF), the accumulation of viscous lung secretions rich in DNA and actin is a major cause of chronic inflammation and recurrent infections leading to airway obstruction.
Danila Delfino +9 more
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RNA Biology, 2023 Ribosomal RNA (rRNA) processing and maturation are fundamentally important for ribosome biogenesis, but the mechanisms in archaea, the third form of life, remains largely elusive.
Lei Qi +6 more
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A Structural Perspective of Reps from CRESS-DNA Viruses and Their Bacterial Plasmid Homologues
Viruses, 2021 Rolling circle replication (RCR) is ubiquitously used by cellular and viral systems for genome and plasmid replication. While the molecular mechanism of RCR has been described, the structural mechanism is desperately lacking.
Elvira Tarasova, Reza Khayat
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Frontiers in Microbiology, 2021 Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Tan Lin +6 more
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Novel genome-editing tools to model and correct primary immunodeficiencies
Frontiers in Immunology, 2015 Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell transplantation, but when HLA-matched donors are lacking, this can be a high-risk procedure ...
Lisa M Ott De Bruin +4 more
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