Results 31 to 40 of about 271,229 (377)
Novel genome-editing tools to model and correct primary immunodeficiencies
Frontiers in Immunology, 2015 Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell transplantation, but when HLA-matched donors are lacking, this can be a high-risk procedure ...
Lisa M Ott De Bruin +4 more
doaj +1 more source
Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G [PDF]
, 2005 BACKGROUND: In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis
Mishra, Rangnath, Simonson, Michael S
core +3 more sources
Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Triplet repeat expansion causes multiple neurological disorders, but the mechanisms of triplet repeat expansion are not well understood.
Lyudmila Y Kadyrova +4 more
semanticscholar +1 more source
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Nature, 2014 The clustered regularly interspaced short palindromic repeats (CRISPR)-associated enzyme Cas9 is an RNA-guided endonuclease that uses RNA–DNA base-pairing to target foreign DNA in bacteria.
S. H. Sternberg +4 more
semanticscholar +1 more source
Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1 [PDF]
, 2019 Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified as ...
Beglov, Dmitri +12 more
core +6 more sources
Scientific Reports, 2018 Baloxavir acid (BXA), derived from the prodrug baloxavir marboxil (BXM), potently and selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of influenza A and B viruses.
S. Omoto +10 more
semanticscholar +1 more source
, 1998 Introns interrupt the continuity of many eukaryal genes, and therefore their removal by splicing is a crucial step in gene expression. Interestingly, even within Eukarya there are at least four splicing mechanisms.
Abelson, John +2 more
core +1 more source
IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]
, 2020 IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear +54 more
core +1 more source
Pharmaceutics, 2021 The adult Göttingen Minipig is an acknowledged model for safety assessment of antisense oligonucleotide (ASO) drugs developed for adult indications.
Allan Valenzuela +13 more
doaj +1 more source
Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates [PDF]
, 2010 Dna2 is a nuclease/helicase with proposed roles in DNA replication, double-strand break repair and telomere maintenance. For each role Dna2 is proposed to process DNA substrates with a 5'-flap.
Aguilera +54 more
core +2 more sources