Results 31 to 40 of about 299,455 (330)

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil

Scientific Reports, 2018
Baloxavir acid (BXA), derived from the prodrug baloxavir marboxil (BXM), potently and selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of influenza A and B viruses.
S. Omoto, V. Speranzini, Takashi Hashimoto, Takeshi Noshi, H. Yamaguchi, M. Kawai, K. Kawaguchi, T. Uehara, T. Shishido, A. Naito, S. Cusack   +10 more
semanticscholar   +1 more source

sgRNA design and in vitro nucleolytic analysis of the Cas9‐RNP complex for transgene‐free genome editing of the eIF4E1 gene from Capsicum an‐ nuum L.

Indonesian Journal of Biotechnology, 2023
Chili (Capsicum annuum L.) is a highly valued vegetable, renowned for its unique taste and aroma. However, chili production faces challenges in meeting the high demand due to infections caused by pathogens such as ChiVMV (potyvirus).
Josefanny Tham, Alfred Patisenah, Tommy Octavianus Soetrisno Tjia, Santiago Signorelli, Intan Taufik, Karlia Meitha   +5 more
doaj   +1 more source

Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]

, 2012
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Achim Schnaufer, Alatortsev, Ammerman, Aphasizheva, Aphasizheva, Bailey, Borst, Carnes, Carnes, Carnes, Cruz-Reyes, Cruz-Reyes, Deschamps, Ernst, Ernst, Etheridge, Fisk, Guo, Guo, Guo, Hashimi, Igo, Igo, Inoue, Jason Carnes, Jensen, Kao, Kenneth Stuart, Koslowsky, Koslowsky, Lukes, Mattiacio, Mattiacio, Melissa Lerch, Militello, Nathalie Acestor, Niemann, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Piller, Rigaut, Ryan, Sabatini, Schnaufer, Schnaufer, Seiwert, Simpson, Stuart, Trotter, Weng, Wirtz, Worthey, Xuemin Guo, Zhang   +58 more
core   +1 more source

Novel genome-editing tools to model and correct primary immunodeficiencies

Frontiers in Immunology, 2015
Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell transplantation, but when HLA-matched donors are lacking, this can be a high-risk procedure ...
Lisa M Ott De Bruin, Lisa M Ott De Bruin, Stefano eVolpi, Stefano eVolpi, Kiran eMusunuru   +4 more
doaj   +1 more source

Alternative end-joining in BCR gene rearrangements and translocations

Acta Biochimica et Biophysica Sinica, 2022
Programmed DNA double-strand breaks (DSBs) occur during antigen receptor gene recombination, namely V(D)J recombination in developing B lymphocytes and class switch recombination (CSR) in mature B cells.
Bai Wanyu, Zhao Bo, Gu Mingyu, Dong Junchao   +3 more
doaj   +1 more source

Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1 [PDF]

, 2019
Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified as ...
Beglov, Dmitri, Brown, Lauren E., Chen, Qiujia, Chennamadhavuni, Spandan, Georgiadis, Millie M., He, Hongzhen, Kelley, Mark R., Panek, James S., Porco, John A., Reed, April, Trilles, Richard, Vajda, Sandor, Wireman, Randall   +12 more
core   +7 more sources

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

Nature, 2014
The CRISPR-associated protein Cas9 is an RNA-guided endonuclease that cleaves double-stranded DNA bearing sequences complementary to a 20-nucleotide segment in the guide RNA.
C. Anders, O. Niewoehner, A. Duerst, M. Jinek   +3 more
semanticscholar   +1 more source

The Diversity of Ribonuclease P: Protein and RNA Catalysts with Analogous Biological Functions

Biomolecules, 2016
Ribonuclease P (RNase P) is an essential endonuclease responsible for catalyzing 5’ end maturation in precursor transfer RNAs. Since its discovery in the 1970s, RNase P enzymes have been identified and studied throughout the three domains of life ...
Bradley P. Klemm, Nancy Wu, Yu Chen, Xin Liu, Kipchumba J. Kaitany, Michael J. Howard, Carol A. Fierke   +6 more
doaj   +1 more source

Bacteria herald a new era of gene editing

eLife, 2013
The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landmark in the rapidly developing field of genome engineering.
David J Segal
doaj   +1 more source

Antiviral Activity and Molecular Dynamics Simulation of Hops Compounds against Oropouche Virus (Peribunyaviridae)

Pharmaceutics, 2023
The Oropouche virus (OROV) is a member of the family Peribunyaviridae (order Bunyavirales) and the cause of a dengue-like febrile illness transmitted mainly by biting midges and mosquitoes.
Tsvetelina Mandova, Marielena Vogel Saivish, Gabriela de Lima Menezes, Katyanna Sales Bezerra, Umberto Laino Fulco, Roosevelt Alves da Silva, Fernando Batista Da Costa, Maurício Lacerda Nogueira   +7 more
doaj   +1 more source