Results 91 to 100 of about 155,310 (382)

Substitutions in the redox-sensing PAS domain of the NifL regulatory protein define an inter-subunit pathway for redox signal transmission [PDF]

, 2011
The Per-ARNT-Sim (PAS) domain is a conserved a/ß fold present within a plethora of signalling proteins from all kingdoms of life. PAS domains are often dimeric and act as versatile sensory and interaction modules to propagate environmental signals to ...
Ayers, Campbell, Demeler, Dixon, Hefti, Hill, Karimova, Key, Kurokawa, Little, Little, Little, Ma, Macheroux, Martinez-Argudo, Matthews, Miyatake, Money, Möglich, Möglich, Möglich, Nan, Perry, Qi, Reyes-Ramirez, Reyes-Ramirez, Slavny, Söderbäck, Taylor, Ukaegbu, Watts, Williamson, Zhou, Zoltowski, Zoltowski   +34 more
core   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Targeted Mutagenesis Using RNA-guided Endonucleases in Mosses

Bio-Protocol, 2017
RNA-guided endonucleases (RGENs) have been used for genome editing in various organisms. Here, we demonstrate a simple method for performing targeted mutagenesis and genotyping in a model moss species, Physcomitrella patens, using RGENs.
Toshihisa Nomura, Hitoshi Sakakibara
doaj   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

EPIGENETICS TODAY AND TOMORROW

Вавиловский журнал генетики и селекции, 2015
Epigenetics is a science of inheritable organism properties that are not associated with changes in the DNA nucleotide sequence but can be indirectly encoded in the genome. The most known epigenetic mechanisms (signals) are enzymatic DNA methylation, the
B. F. Vanyushin
doaj  

Topological digestion drives time-varying rheology of entangled DNA fluids

Nature Communications, 2022
Understanding and controlling the rheology of polymeric complex fluids is of fundamental importance in both industry and biology. Here, Michieletto et al. show how to achieve time-dependent rheology of DNA solutions via enzymatically-driven architectural
D. Michieletto, P. Neill, S. Weir, D. Evans, N. Crist, V. A. Martinez, R. M. Robertson-Anderson   +6 more
doaj   +1 more source

Interplay between Structure-Specific Endonucleases for Crossover Control during Caenorhabditis elegans Meiosis

PLoS Genetics, 2013
The number and distribution of crossover events are tightly regulated at prophase of meiosis I. The resolution of Holliday junctions by structure-specific endonucleases, including MUS-81, SLX-1, XPF-1 and GEN-1, is one of the main mechanisms proposed for
Takamune T. Saito, Doris Y. Lui, Hyun-Min Kim, Katherine Meyer, M. Colaiácovo   +4 more
semanticscholar   +1 more source

Preservation of Complex Multiphase Architectures in Polymer‐Based Artificial Cells by Photo‐Crosslinking

Advanced Science, EarlyView.
Phase separation organizes cellular components, yet stabilizing such dynamic structures in artificial cells remains challenging. A photo‐crosslinking approach is presented that prolongs the lifetime of different structures in coacervate‐based artificial cells while maintaining dynamic formation.
Madelief A. M. Verwiel, Alexander B. Cook, Yiǧitcan Sümbelli, Nadia A. Erkamp, Jan C. M. van Hest   +4 more
wiley   +1 more source

Genetic diversity among Frankia strains nodulating members of the family Casuarinaceae in Australia revealed by PCR and restriction fragment length polymorphism analysis with crushed root nodules [PDF]

, 1996
DNA extracted directly from nodules was used to assess the genetic diversity of #Frankia# strains symbiotically associated with two species of genus #Casuarina# and two of the genus #Allocasuarina# naturally occuring in northeastern Australia.
Normand, Philippe, Prin, Yves, Reddell, Paul, Rouvier, Carole, Simonet, Pascal   +4 more
core  

A small RNA response at DNA ends in Drosophila [PDF]

, 2012
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy, Förstemann, Klaus, Michalik, Katharina M.   +2 more
core   +1 more source