Results 241 to 250 of about 65,125 (289)

Beyond Nucleotide Excision Repair: The Importance of XPF in Base Excision Repair and Its Impact on Cancer, Inflammation, and Aging. [PDF]

Int J Mol Sci
Gohil D, Roy R.
europepmc   +1 more source

DDX3 Regulates the Cap‐Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome

Advanced Science, Volume 12, Issue 27, July 17, 2025.
Japanese encephalitis virus (JEV) employs a cap‐independent (CI) translation strategy to evade host translational shutoff. During the shut‐off of host cellular canonical translation, DEAD‐box protein 3 (DDX3) bind to JEV UTRs to establish a closed‐loop architecture, and its interaction with poly(A)‐binding protein 1 (PABP1) to form DDX3/PABP1/eIF4G ...
Chenxi Li, Linjie Zhang, Chenyang Tang, Xuan Chen, Jing Shi, Qingyu Li, Xue Jiao, Jinyao Guo, Bin Wang, Kefan Bu, Abdul Wahaab, Yuguo Yuan, Ming‐an Sun, Yanhua Li   +13 more
wiley   +1 more source

Identification and purification of a novel bacteriophage T7 endonuclease from the Kogelberg Biosphere Reserve (KBR) biodiversity hotspot. [PDF]

Biotechnol Rep (Amst)
Pillay P, Moralo M, Mtimka S, Shai T, Botha K, Kwezi L, Tsekoa TL.   +6 more
europepmc   +1 more source

Electrochemical‐Genetic Programming of Protein‐Based Magnetic Soft Robots for Active Drug Delivery

Advanced Science, Volume 12, Issue 27, July 17, 2025.
This manuscript presents a protein‐based soft robot for active drug delivery. Stimuli‐responsive protein is rationally designed and processed into the substrate of robots. Superparamagnetic Fe3O4 nanoparticles are patterned on the substrate using an electrochemical method, enabling the robot to respond to external physical fields.
Hang Zhao, Bo Yu, Dingyi Yu, Ting Ji, Kexin Nie, Jingyi Tian, Xinchen Shen, Kaiyue Zhang, Junhan Ou, Xinyi Yang, Dongfang Xiao, Qi Zhou, Wenwen Huang   +12 more
wiley   +1 more source

WRNexo is not required to maintain normal sex ratios in Drosophila: A CURE-Based Investigation. [PDF]

MicroPubl Biol
Bolterstein E, Mungre S, Nuss K, Stoffregen EP.   +3 more
europepmc   +1 more source

Focused ultrasound‐mediated APOE4 knockdown in mouse brain

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION The apolipoprotein E (APOE) ε4 allele is widely recognized as the strongest genetic risk factor for late‐onset Alzheimer's disease. Therapeutic strategies to reduce apoE4 expression in APOE ε4 carriers hold promise to mitigate neuroinflammatory and neurodegenerative processes driving disease progression. METHODS Focused ultrasound
Kaiyuan Zheng, Fotios N. Tsitsos, Alec J. Batts, Robin Ji, Tal Nuriel, Elisa E. Konofagou, Kam W. Leong   +6 more
wiley   +1 more source

Cell-Free DNA: Features and Attributes Shaping the Next Frontier in Liquid Biopsy. [PDF]

Mol Diagn Ther
Swarup N, Leung HY, Choi I, Aziz MA, Cheng JC, Wong DTW.   +5 more
europepmc   +1 more source

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes

Angewandte Chemie International Edition, Volume 64, Issue 27, July 1, 2025.
The highly negatively charged phosphodiester groups of nucleic acids and cyclic (di‐)nucleotides often interact with amino acids containing polar or positively charged sidechains. Due to charge repulsion with their negatively charged carboxylate groups in their side chains, glutamate and aspartate are considered to be detrimental to such interactions ...
Konstantin Neißner, Elke Duchardt‐Ferner, Christoph Wiedemann, Julian Kraus, Ute A. Hellmich, Jens Wöhnert   +5 more
wiley   +1 more source

Identification and characterization of a dsRNA-degrading nuclease CmdsRNase2 influencing RNAi efficiency in the rice leaffolder Cnaphalocrocis medinalis. [PDF]

Sci Rep
Wang X, Du J, Li S, Li J, Zha R.
europepmc   +1 more source