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The hunt for the 3′endonuclease [PDF]
WIREs RNA, 2010 AbstractPre‐mRNAs are typically processed at the 3′end by cleavage/polyadenylation. This is a two‐step processing reaction initiated by endonucleolytic cleavage of pre‐mRNAs downstream of the AAUAAA sequence or its variant, followed by extension of the newly generated 3′end with a poly(A) tail.
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The Use of Restriction Endonucleases
2003The discovery of the mode of action of the class of bacterial enzymes known as restriction endonucleases provided the major breakthrough in opening up the field of genetic engineering. In vivo, these enzymes are involved in recognizing and cutting up foreign DNA entering the cell; their most likely role is thus protecting the bacteria against phage ...
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Restriction Endonuclease Digestion of DNA
2003The ability to cleave DNA at specific sites is one of the cornerstones of today's methods of DNA manipulation. Restriction endonucleases are bacterial enzymes that cleave duplex DNA at specific target sequences with the production of defined fragments. These enzymes can be purchased from the many manufacturers of biotechnology products.
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Damage Specific Mammalian Endonucleases
1990A broad spectrum of agents are known to react with DNA, and the resulting changes in structure may have deleterious biological consequences, if not removed. Modified bases in DNA can be excised from DNA by different repair pathways. The process of excision repair involves four major steps: incision, excision, DNA synthesis, and ligation of the repaired
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