Results 21 to 30 of about 83,074 (351)

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

Nature Communications, 2020
Asparaginyl endopeptidases (AEPs) catalyze the key backbone cyclization step during the biosynthesis of plant-derived cyclic peptides. Here, we report the identification of two AEPs from Momordica cochinchinensis and biochemically characterize MCoAEP2 ...
Junqiao Du, K. Yap, L. Y. Chan, Fabian B. H. Rehm, Fong Yang Looi, Aaron G. Poth, E. Gilding, Q. Kaas, T. Durek, D. Craik   +9 more
semanticscholar   +1 more source

Gut microbial DL-endopeptidase alleviates Crohn's disease via the NOD2 pathway [PDF]

, 2022
The pattern-recognition receptor NOD2 senses bacterial muropeptides to regulate host immunity and maintain homeostasis. Loss-of-function mutations in NOD2 are associated with Crohn's disease (CD), but how the variations in microbial factors influence ...
Fu, Jingyuan, Gao, Jie, He, Xiaolong, Hu, Mengyao, Hu, Shixian, Huang, Zhenhe, Jin, Shaoqin, Lu, Bingyun, Sun, Kai, Wang, Zhang, Weersma, Rinse K., Zhao, Xinmei, Zhou, Hongwei   +12 more
core   +2 more sources

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]

, 2012
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Alison Seed, Ando, Anthony P. Davenport, Battistini, Bayes, Bucchwalder-Csajka, Chen, Christopher Hillier, D'Orleans-Juste, Davenport, Davenport, Davenport, Dhaun, Dickstein, Dive, Emoto, Favrat, Fecteau, Ferro, Fiona Johnston, Flather, Garg, Hand, Hanka J. de Voogd, Hans Essers, Haynes, Haynes, Janet J. Maguire, Jardine, John McMurray, Johnstrom, Kentsch, Ling, Love, Maguire, Maguire, Maguire, McDonagh, McDowell, Naruse, Newby, Northridge, Northridge, O'Connell, Palmer, Plumpton, Rhoda E. Kuc, Richards, Richards, Richards, Rousso, Russell, Russell, Russell, Russell, Schirger, Tabrizchi, Thöne-Reinke, Vachiéry, Van der Meer, Xu, Yanagisawa, Yusuf   +62 more
core   +2 more sources

Characterization of LysBC17, a Lytic Endopeptidase from Bacillus cereus

Antibiotics, 2019
Bacillus cereus, a Gram-positive bacterium, is an agent of food poisoning. B. cereus is closely related to Bacillus anthracis, a deadly pathogen for humans, and Bacillus thuringenesis, an insect pathogen.
Steven M. Swift, Irina V. Etobayeva, Kevin P. Reid, Jerel J. Waters, Brian B. Oakley, David M. Donovan, Daniel C. Nelson   +6 more
doaj   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Potential Activities of Freshwater Exo- and Endo-Acting Extracellular Peptidases in East Tennessee and the Pocono Mountains

Frontiers in Microbiology, 2018
Proteins constitute a particularly bioavailable subset of organic carbon and nitrogen in aquatic environments but must be hydrolyzed by extracellular enzymes prior to being metabolized by microorganisms.
Lauren Mullen, Malcolm X Shabazz High School Aquatic Biogeochemistry Team, Kim Boerrigter, Kim Boerrigter, Nicholas Ferriero, Jeff Rosalsky, Abigail van Buren Barrett, Patrick J. Murray, Andrew D. Steen   +8 more
doaj   +1 more source

Presence and expression of hydrogenase specific C-terminal endopeptidases in cyanobacteria [PDF]

, 2003
BACKGROUND: Hydrogenases catalyze the simplest of all chemical reactions: the reduction of protons to molecular hydrogen or vice versa. Cyanobacteria can express an uptake, a bidirectional or both NiFe-hydrogenases.
Batur, Mehtap, Lindblad, Peter, Wünschiers, Röbbe   +2 more
core   +3 more sources

Changes in protein profile during coagulation of latex from Carica papaya

Brazilian Journal of Medical and Biological Research, 1997
We describe the changes in peptide composition by SDS-PAGE analysis of latex from Carica papaya collected at various times after incision of the unripe fruit.
L.G. Silva, O. Garcia, M.T.P. Lopes, C.E. Salas   +3 more
doaj   +1 more source

TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity

Frontiers in Cell and Developmental Biology, 2022
Small ubiquitin-like modifier (SUMO) modification plays an important regulatory role in T cell receptor (TCR) signaling transduction. SUMO-specific proteases (SENPs) have dual-enzyme activities; they can both process SUMO precursors as endopeptidases and
Yun-Yi Li, Haohua Cen, Bei-Ni Gong, Siqi Mai, Qi-Long Wang, Sisi Mou, Yingqiu Li   +6 more
doaj   +1 more source

Macrocyclization by asparaginyl endopeptidases [PDF]

New Phytologist, 2017
Contents Summary 923 I. Introduction 923 II. Plant AEPs with macrocyclizing ability 924 III. Mechanism of macrocyclization by AEPs 925 IV. Conclusions 927 Acknowledgements 927 References 927 SummaryPlant asparaginyl endopeptidases (AEPs) are important for the post‐translational processing of seed storage proteins via ...
Amy M. James, Joshua S. Mylne, Joel Haywood   +2 more
openaire   +3 more sources