Results 41 to 50 of about 82,787 (343)

Crystal Structure of Bovine Alpha-Chymotrypsin in Space Group P6₅

Crystals, 2018
Chymotrypsin is a protease that is commonly used as a standard for protein crystallization and as a model system for studying serine proteases. Unliganded bovine α-chymotrypsin was crystallized at neutral pH using ammonium sulphate as the precipitant ...
Andrew C. Marshall, Benjamin G. Keiller, Jordan L. Pederick, Andrew D. Abell, John B. Bruning   +4 more
doaj   +1 more source

Recommended Immunological Strategies to Screen for Botulinum Neurotoxin-Containing Samples

Toxins, 2015
Botulinum neurotoxins (BoNTs) cause the life-threatening neurological illness botulism in humans and animals and are divided into seven serotypes (BoNT/A–G), of which serotypes A, B, E, and F cause the disease in humans. BoNTs are classified as “category
Stéphanie Simon, Uwe Fiebig, Yvonne Liu, Rob Tierney, Julie Dano, Sylvia Worbs, Tanja Endermann, Marie-Claire Nevers, Hervé Volland, Dorothea Sesardic, Martin B. Dorner   +10 more
doaj   +1 more source

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease

Nature Network Boston, 2014
Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerous aging-related neurodegenerative diseases, including Alzheimer's disease (AD).
Zhentao Zhang, Ming-ke Song, Xia Liu, S. Kang, Il‐Sun Kwon, D. Duong, N. Seyfried, William T. Hu, Zhixue Liu, Jian-Zhi Wang, Liming Cheng, Y. Sun, S. Yu, A. Levey, K. Ye   +14 more
semanticscholar   +1 more source

Yeast Derived LysA2 Can Control Bacterial Contamination in Ethanol Fermentation

Viruses, 2018
Contamination of fuel-ethanol fermentations continues to be a significant problem for the corn and sugarcane-based ethanol industries. In particular, members of the Lactobacillaceae family are the primary bacteria of concern.
Jun-Seob Kim, M. Angela Daum, Yong-Su Jin, Michael J. Miller   +3 more
doaj   +1 more source

Specificity of prolyl endopeptidase [PDF]

FEBS Letters, 1986
A series of tetrapeptides, Cbz(Bz)‐Gly‐X‐Leu‐Gly, were synthesized and the kinetic parameters, k cat and , determined for their hydrolyses by prolyl endopeptidase from Flavobacterium. The peptides with X = N‐Me‐Ala, Sar and Ala as well as the standard substrate (X = Pro) were found to be good substrates, while those with X = α‐aminobutyryl, Hyp, Ser ...
openaire   +3 more sources

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase [PDF]

, 2009
l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism.
Abshire, Asselin, Aung, Carly Leighton, Catherine X. Moss, Clare Dempsey, Colin Watts, Fine, Frederik W. van Delft, Hany Ariffin, JiZhong Liu, Marc N. Offman, Marcin Krol, Mark Holland, Monika Essink, Naina Patel, Offman, Paul A. Bates, Rizzari, Seema Alexander, Shekhar Krishnan, Tim O.B. Eden, van Zelm, Vaskar Saha   +23 more
core   +4 more sources

Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.

Journal of Medicinal Chemistry, 2017
Asparagine endopeptidase (AEP), also called legumain, is highly expressed in various solid tumors, promoting cancer cell invasion, migration, and metastasis.
Q. Qi, Obiamaka Obianyo, Yuhong Du, H. Fu, Shiyong Li, K. Ye   +5 more
semanticscholar   +1 more source

Role of the liver in splanchnic extraction of atrial natriuretic factor in the rat [PDF]

, 1992
Mesenteric, hepatic and splanchnic extraction of C-terminal and N-terminal atrial natriuretic factor was investigated in male Sprague-Dawley rats. Plasma concentrations (mean ± S.E.M.) of C-terminal atrial natriuretic factor were 55.0 ± 6.1 fmol/ml, 31.2
Alexander L. Gerbes, Arendt, Casado, Crozier, De Bold, Dieter Jüngst, Epstein, Gaétan Thibault, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gines, Gutkowska, Henriksen, Henriksen, Hollister, Inagami, Johnson, Krieter, Krieter, Kurusawa, Lang, Laragh, Manfred Bilzer, Masuda, Moreau, Nair, Needleman, Rochus Witthaut, Schütten, Sundsfjord, Tamburini, Thibault, Veit Gülberg, Veseley, Vierhapper, Vollmar, Widimsky   +39 more
core   +1 more source

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

Nature Communications, 2015
Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive.
K. Harris, T. Durek, Q. Kaas, Aaron G. Poth, E. Gilding, Brendon F. Conlan, I. Saska, N. Daly, N. L. van der Weerden, D. Craik, M. Anderson   +10 more
semanticscholar   +1 more source

Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides

Nature Communications, 2022
Muscle contraction depends on strictly controlled calcium transients within myocytes. Here, the authors show that the endopeptidase Neprilysin 4 represents an essential regulator of these transients and, consequently, of proper heart function.
Ronja Schiemann, Annika Buhr, Eva Cordes, Stefan Walter, Jürgen J. Heinisch, Paola Ferrero, Hendrik Milting, Achim Paululat, Heiko Meyer   +8 more
doaj   +1 more source