Results 201 to 210 of about 636,928 (251)

Calcium signaling and endoplasmic reticulum stress.

International Review of Cell and Molecular Biology, 2021
Cellular homeostasis is essential for healthy functioning of cells and tissues as well as proper organ development and maintenance. A disruption in cellular homeostasis triggers stress responses including the unfolded protein response (UPR), an ...
J. Groenendyk, L. Agellon, M. Michalak
semanticscholar   +1 more source

Exiting the endoplasmic reticulum

Molecular and Cellular Endocrinology, 2001
The movement of nascent proteins from sites of synthesis to final cellular or extracellular destinations involves their transport through a distinct series of vesicular compartments. Vesicle biogenesis is regulated by specific proteins and co-factors that control distinct steps including budding, transport, docking, and fusion with target membranes ...
F S, Gorelick, C, Shugrue
openaire   +2 more sources

Subcompartments of the endoplasmic reticulum

Seminars in Cell Biology, 1992
The endoplasmic reticulum (ER) is the largest continuous endomembrane structure in the cytoplasm. It may be viewed as a series of unique subcompartments. In this review, we examine the rough ER, nuclear envelope and several smooth ER subcompartments. Consideration is given to the characteristic properties and functions of the ER and its domains, and to
B M, Vertel, L M, Walters, D, Mills
openaire   +2 more sources

Exiting the Endoplasmic Reticulum

Traffic, 2005
Vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex constitutes the initial step in protein secretion. COPII‐coated vesicles mediate the export of newly synthesized proteins from the ER, and this transport step is coupled with COPI‐mediated retrograde traffic to form a transport circuit that supports the compositional asymmetry
Joseph D, Mancias, Jonathan, Goldberg
openaire   +2 more sources

On the functions of the endoplasmic reticulum

Biochemical Pharmacology, 1961
Abstract Ribonucleoprotein (RNP) particles were purified in a highly active state from a number of tissues of the rat. Particle yield varied considerably for different tissues but the composition of particles was fairly similar. From the early blastula stage of Psammechinus eggs active particles were also obtained, and at a higher yield than from ...
openaire   +2 more sources

Networking in the endoplasmic reticulum

Biochemical Society Transactions, 2010
The network of the ER (endoplasmic reticulum) is set up by cytoskeletal control of the movement and remodelling of polygonal rings of tubules, bundles of tubules and cisternal regions. We have developed a new image analysis tool, persistency mapping, to understand the framework upon which the plant ER remodels.
openaire   +2 more sources

Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy.

Nano letters (Print), 2020
Immunogenic cell death (ICD) elicited by photodynamic therapy (PDT) is mediated through generation of reactive oxygen species (ROS) that induce endoplasmic reticulum (ER) stress. However, the half-life of ROS is very short and the intracellular diffusion
Hong-Zhang Deng, Zijian Zhou, Weijing Yang, Li-Sen Lin, Sheng Wang, Gang Niu, Ji-Bin Song, X. Chen   +7 more
semanticscholar   +1 more source

Origin of the Endoplasmic Reticulum

Nature, 1962
To propose a mechanism of origin of the endoplasmic reticulum based on a study of yeast cytology may seem presumptuous because there is no field in which so many different opinions prevail. The variety of opinions have arisen because yeasts, like all acellular (single-celled) organisms, manifest a maximal diversity of internal organization, and a ...
openaire   +2 more sources

An Endoplasmic Reticulum Targeted Ratiometric Fluorescent Probe for Sensing of Hydrogen Sulfide in Living Cells and Zebrafish.

Analytical Chemistry, 2020
Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule in many physiological processes. Relevant investigations indicated that H2S plays a cytoprotective effect under endoplasmic reticulum stress.
Wei Shu, Shunping Zang, Chong Wang, Mengxu Gao, Jing Jing, Xiao-Ling Zhang   +5 more
semanticscholar   +1 more source

Crosstalk between Endoplasmic Reticulum stress and oxidative stress:Focus on Protein Disulfide Isomerase and Endoplasmic Reticulum Oxidase 1.

European Journal of Pharmacology, 2020
Cellular stress and inflammation, establishing as disease pathology, have reached great heights in the last few decades. Stress conditions such as hyperglycemia, hyperlipidemia and lipoproteins are known to disturb proteostasis resulting in the ...
Paul Victor, D. Sarada, K. Ramkumar
semanticscholar   +1 more source