Results 241 to 250 of about 481,400 (346)

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

open access: yesAdvanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu   +9 more
wiley   +1 more source

The kinesin Kar3 is required for endoplasmic reticulum-associated degradation. [PDF]

open access: yesMol Biol Cell
Akoto E   +16 more
europepmc   +1 more source

Unveiling Macrophage Content as a Predictive Biomarker for Intraoperative ICG Imaging Efficacy in Lung Cancer

open access: yesAdvanced Science, EarlyView.
Indocyanine Green (ICG)‐guided lung cancer surgery efficacy varies significantly among patients. This study identifies tumor macrophage content as a predictive biomarker. Macrophages are primary ICG reservoirs, storing seven‐fold more ICG than cancer cells.
Yue Yan   +13 more
wiley   +1 more source

Endoplasmic reticulum-Mitochondria Coupling in Alzheimer's Disease. [PDF]

open access: yesContact (Thousand Oaks)
Rossini M   +3 more
europepmc   +1 more source

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway

open access: yesAdvanced Science, EarlyView.
By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang   +10 more
wiley   +1 more source

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