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In Vitro Reconstitution of the Endoplasmic Reticulum
Current Protocols in Cell Biology, 2017AbstractReconstitution of cellular organelles in vitro offers the possibility to perform quantitative and qualitative experiments in a controlled environment that cannot be done with the same accuracy in living cells. Following a previous report, the subsequent list of protocols describes how to reconstitute and quantify a tubular ER network in vitro ...
Brigitte Neumann +7 more
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Serpinopathy and endoplasmic reticulum stress
Medical Molecular Morphology, 2005We have recently identified a novel human gene, megsin, which is a new serine protease inhibitor (serpin) predominantly expressed in the kidney. Our previous studies suggested a role of megsin in the pathogenesis of human renal diseases, but its exact biopathological significance remained unknown.
Toshio Miyata +3 more
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1989
The endoplasmic reticulum (ER) may form up to half of the cell’s total membrane (table 1.1). This proportion is strikingly high in those cells specialised for the export of lipids (such as hepatocytes and cells of the gonads) or of proteins (such as pancreatic cells or certain classes of B lymphocytes).
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The endoplasmic reticulum (ER) may form up to half of the cell’s total membrane (table 1.1). This proportion is strikingly high in those cells specialised for the export of lipids (such as hepatocytes and cells of the gonads) or of proteins (such as pancreatic cells or certain classes of B lymphocytes).
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1992
Publisher Summary This chapter presents the current understanding of the structural elements that make up endoplasmic reticulum (ER). The primary structural elements of the ER are the molecular components such as the proteins, lipids, and ions. The secondary elements are the local organizational motifs formed by the individual components. In the case
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Publisher Summary This chapter presents the current understanding of the structural elements that make up endoplasmic reticulum (ER). The primary structural elements of the ER are the molecular components such as the proteins, lipids, and ions. The secondary elements are the local organizational motifs formed by the individual components. In the case
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Cell Calcium, 2015
There are a number of known and suspected channels and exchangers in the endoplasmic reticulum that may participate in potassium flux across its membrane. They include trimeric intracellular cation channels permeable for potassium, ATP-sensitive potassium channels, calcium-activated potassium channels and the potassium-hydrogen exchanger.
Kuum, Malle +2 more
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There are a number of known and suspected channels and exchangers in the endoplasmic reticulum that may participate in potassium flux across its membrane. They include trimeric intracellular cation channels permeable for potassium, ATP-sensitive potassium channels, calcium-activated potassium channels and the potassium-hydrogen exchanger.
Kuum, Malle +2 more
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1988
Publisher Summary This chapter discusses the microscopic structure of endoplasmic reticulum. There are two main morphological types of endoplasmic reticulum: (1) the granular or rough endoplasmic reticulum and (2) the agranular or smooth endoplasmic reticulum.
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Publisher Summary This chapter discusses the microscopic structure of endoplasmic reticulum. There are two main morphological types of endoplasmic reticulum: (1) the granular or rough endoplasmic reticulum and (2) the agranular or smooth endoplasmic reticulum.
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Chapter 21 Import into the Endoplasmic Reticulum
1995Publisher Summary This chapter discusses import into the endoplasmic reticulum. Proteins destined to the endoplasmic reticulum (ER), the Golgi complex, the vacuole, and the plasma membrane are first imported into the ER before being targeted to their final destination.
Ceriotti Aldo +3 more
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Endoplasmic Reticulum Stress and Obesity
2017In recent years, the world has seen an alarming increase in obesity and is closely associated with insulin resistance, which is a state of low-grade inflammation, the latter characterized by elevated levels of proinflammatory cytokines in blood and tissues.
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The Lipid Droplet and the Endoplasmic Reticulum
2017Lipid droplets (LDs) are often found adjacent to the endoplasmic reticulum (ER). The ER-LD association may appear morphologically similar to the prototypical membrane contact sites found between the ER and other organelles, but the functional relationship between the ER and LDs is unique in that highly hydrophobic lipid esters are transported between ...
Yuki Ohsaki +2 more
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The Endoplasmic Reticulum Pathway [PDF]
, 2009 Virtually all organisms adapt to stress in order to prolong their survival. At the subcellular level, the endoplasmic reticulum (ER) responds to stress by inducing ER-specific signaling pathways to reestablish homeostasis between protein synthesis and processing, a mechanism called the unfolded protein response (UPR).
Michael W. Harr, Clark W. Distelhorst
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