Results 41 to 50 of about 6,017 (150)

Broadening the View: Substance P and Its Metabolism in Pruritus-Related Diseases. [PDF]

J Dermatol
ABSTRACT Chronic pruritus is a debilitating symptom accompanying numerous inflammatory skin diseases and remains a major therapeutic challenge. Neurogenic inflammation plays a central role in its pathogenesis, with the tachykinin substance P acting as a key mediator at the interface of the nervous system, immune cells, and cutaneous tissues.
Walter T, Burckhardt BB.
europepmc   +2 more sources

An Ultrastructural and Proteomic Analysis in DM1 Young Adults' Myoblasts: Stressed RER and Mitochondrial Dysfunction Involvement. [PDF]

J Cell Mol Med
ABSTRACT Myotonic dystrophy type 1 (DM1) is a progressive muscular disorder caused by the expansion of CTG repeats in the 3′ UTR of the DMPK gene. Although the pathogenic mechanisms remain unclear, recent evidence suggests that activation of innate immune responses may contribute to disease progression. In this study, we examined the ultrastructure and
Del Carratore R, Falleni A, Bernardeschi M, Frenzilli G, Ripolone M, Salani S, Geraci F, Miraglia F, Del Seppia C.   +8 more
europepmc   +2 more sources

Human leukocyte antigen B polymorphism and association between HLA‐B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh

Rheumatology & Autoimmunity, 2022
Objectives To determine the association of Human leukocyte antigen B (HLA‑B) alleles with ankylosing spondylitis and the allelic association of HLA‐B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single‐nucleotide polymorphism (SNP) rs30187 in ...
Md Kamrul H. Sajib, Shamim Ahmed, Syed A. Haq, Minhaj R. Choudhury, Mohammed Uddin, Furkan Uddin, Muhammad S. A. Khan, Mohammad M. Zaman   +7 more
doaj   +1 more source

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

PLoS ONE, 2008
BackgroundEndoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I molecules.
Irini Evnouchidou, Frank Momburg, Athanasios Papakyriakou, Angeliki Chroni, Leondios Leondiadis, Shih-Chung Chang, Alfred L Goldberg, Efstratios Stratikos   +7 more
doaj   +1 more source

Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis

RMD Open, 2023
The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility.
Joachim Sieper, Juergen Braun
doaj   +1 more source

ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses

BMC Immunology, 2022
Background In addition to its role in antigen presentation, recent reports establish a new role for endoplasmic reticulum aminopeptidase 1 (ERAP1) in innate immunity; however, the mechanisms underlying these functions are not fully defined. We previously
Maja K. Blake, Patrick O’Connell, Yuliya Pepelyayeva, Sarah Godbehere, Yasser A. Aldhamen, Andrea Amalfitano   +5 more
doaj   +1 more source

Evolutionary selection identifies critical immune-relevant genes in lung cancer subtypes

Frontiers in Genetics, 2022
In an evolving population, proliferation is dependent on fitness so that a numerically dominant population typically possesses the most well adapted phenotype.
Kimberly A. Luddy, Kimberly A. Luddy, Jamie K. Teer, Audrey Freischel, Cliona O’Farrelly, Cliona O’Farrelly, Robert Gatenby, Robert Gatenby   +7 more
doaj   +1 more source

Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo. [PDF]

Mol Cell Proteomics, 2012
The association of ERAP1 with ankylosing spondylitis (AS)1 among HLA-B27-positive individuals suggests that ERAP1 polymorphism may affect pathogenesis by altering peptide-dependent features of the HLA-B27 molecule. Comparisons of HLA-B*27:04-bound peptidomes from cells expressing different natural variants of ERAP1 revealed significant differences in ...
García-Medel N, Sanz-Bravo A, Van Nguyen D, Galocha B, Gómez-Molina P, Martín-Esteban A, Alvarez-Navarro C, de Castro JA.   +7 more
europepmc   +4 more sources

A role for naturally occurring alleles of Endoplasmic Reticulum Aminopeptidases in tumor immunity and cancer predisposition

Frontiers in Oncology, 2014
Endoplasmic Reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are key components on the pathway that generates antigenic epitopes for presentation to cytotoxic T-lymphocytes (CTLs).
Efstratios eStratikos, Athanasios eStamogiannos, Efthalia eZervoudi, Doriana eFruci   +3 more
doaj   +1 more source

Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection

Frontiers in Immunology, 2019
Background: Haplotype-specific alternative splicing of the endoplasmic reticulum (ER) aminopeptidase type 2 (ERAP2) gene results in either full-length (FL, haplotype A) or alternatively spliced (AS, haplotype B) mRNA.
Irma Saulle, Salomè Valentina Ibba, Enrica Torretta, Cecilia Vittori, Claudio Fenizia, Federica Piancone, Davide Minisci, Elisa Maria Lori, Daria Trabattoni, Cecilia Gelfi, Cecilia Gelfi, Mario Clerici, Mario Clerici, Mara Biasin   +13 more
doaj   +1 more source