Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population [PDF]
Frontiers in ImmunologyIntroductionRheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II, nevertheless some HLA class I associations have also been observed.
Agnieszka Tarnowska +2 more
exaly +6 more sources
A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs [PDF]
Cell GenomicsSummary: Single-nucleotide polymorphisms (SNPs) near the ERAP2 gene are associated with various autoimmune conditions, as well as protection against lethal infections. Due to high linkage disequilibrium, numerous trait-associated SNPs are correlated with
Wouter Venema +2 more
exaly +8 more sources
Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions [PDF]
Frontiers in Cell and Developmental BiologyIntroductionEndoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) modulate a plethora of physiological processes for the maintenance of homeostasis in different cellular subsets at both intra and extracellular level.Materials and methodsIn this ...
Mario Clerici, Mara Biasin
exaly +7 more sources
ERAP2 Is Associated With Immune Infiltration and Predicts Favorable Prognosis in SqCLC [PDF]
Frontiers in Immunology, 2021 BackgroundImmunotherapy has been proven effective among several human cancer types, including Squamous cell lung carcinoma (SqCLC). ERAP2 plays a pivotal role in peptide trimming of many immunological processes.
Zhenlin Yang, Jiachen Xu, Renda Li
exaly +5 more sources
A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection? [PDF]
Cells, 2020 Following influenza infection, rs2248374-G ERAP2 expressing cells may transcribe an alternative spliced isoform: ERAP2/Iso3. This variant, unlike ERAP2-wt, is unable to trim peptides to be loaded on MHC class I molecules, but it can still dimerize with ...
Irma Saulle +2 more
exaly +5 more sources
Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection [PDF]
Frontiers in Immunology, 2019 Background: Haplotype-specific alternative splicing of the endoplasmic reticulum (ER) aminopeptidase type 2 (ERAP2) gene results in either full-length (FL, haplotype A) or alternatively spliced (AS, haplotype B) mRNA.
Irma Saulle +2 more
exaly +5 more sources
Frontiers in Immunology, 2021 Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked ERAP2 with BU, an aminopeptidase which trims peptides before their presentation by HLA class I at the cell ...
Sanne Hiddingh +2 more
exaly +3 more sources
Frontiers in Immunology, 2022 The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum (ERAP1 and
Giorgia Paldino +2 more
exaly +3 more sources
The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis [PDF]
BMC Infectious DiseasesBackground Genetic variations in endoplasmic reticulum aminopeptidase (ERAP1, ERAP2) genes are associated with the pathogenesis of multiple diseases, including infectious diseases.
Shi-Hong Su +7 more
doaj +2 more sources
Evaluating the causal effect of circulating proteome on the risk of Juvenile idiopathic arthritis: an omics pipeline study [PDF]
Pediatric Rheumatology Online JournalBackground Genome-wide association studies (GWAS) have pinpointed a multitude of risk loci associated with Juvenile Idiopathic Arthritis (JIA), but it is challenging to decipher novel plasma proteins.
Xinglin Wu +6 more
doaj +2 more sources