Results 1 to 10 of about 3,465 (162)

Impact of ERAP1 downregulation on the pathogenesis of DSS-induced colitis and therapeutic response to sulfasalazine [PDF]

Frontiers in Immunology
IntroductionUlcerative colitis (UC) is a life-threatening heterogeneous condition characterized by inflammation of the colon. Endoplasmic reticulum aminopeptidase 1 (ERAP1) is essential for antigen processing and immune regulation, however, its specific ...
Bushra Riaz, Bushra Riaz, Hye-Myung Ryu, S. M. Shamsul Islam, Rahar Babita, Je Kyung Seong, Je Kyung Seong, Je Kyung Seong, Ho Lee, Eunjoo H. Lee, Seonghyang Sohn, Seonghyang Sohn, Seonghyang Sohn   +12 more
doaj   +5 more sources

Expression and Role of ERAP1 in Placental Tissues of Preeclampsia

Hypertension in Pregnancy, 2020
Objective This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis. Methods ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot.
Jianbo Wu
exaly   +3 more sources

Functional ERAP1 Variants Distinctively Associate with Ankylosing Spondylitis Susceptibility under the Influence of HLA-B27 in Taiwanese

Cells, 2022
Epistasis of ERAP1 single nucleotide variations (SNVs) and HLA-B27 has been linked to ankylosing spondylitis susceptibility (AS). The current study examined how prevalent ERAP1 allelic variants (SNV haplotypes) in Taiwan affect ERAP1 functions and AS ...
Chin-Man Wang, Ming-Kun Liu, Yeong-Jian Jan Wu, Jing-Chi Lin, Jian-Wen Zheng, Jianming Wu, Ji-Yih Chen   +6 more
doaj   +2 more sources

The impact of ERAP1 inhibition on metabolite homeostasis of melanoma cells [PDF]

Scientific Reports
Manipulation of the activity of Endoplasmic Reticulum AminoPeptidase 1 (ERAP1) has emerged as a powerful tool for the modulation of the cellular antigenicity and concomitant adaptive immune responses, with potential applications in cancer immunotherapy ...
Aroosha Raja, Martha Nikopaschou, Joke H. de Boer, Jeannette Ossewaarde-van Norel, Anna Artati, Michael Witting, Efstratios Stratikos, Jonas J. W. Kuiper   +7 more
doaj   +2 more sources

Exploring the Involvement of ERAP1 in the Pathogenesis of Non-Infectious Uveitis: A Systematic Review [PDF]

Life
Background: Non-infectious uveitis (NIU) is an inflammatory ocular condition often associated with systemic immune-mediated disorders. The pathogenesis of NIU is complex and involves genes from the Human Leukocyte Antigen (HLA) class I system ...
Ioana-Maria Rizea, Horia Tudor Stanca, Vasile Potop, Dana-Margareta-Cornelia Dăscălescu, Silvia Ioana Andrei, Ioana Teodora Tofolean, Alina Popa-Cherecheanu, Mihnea Munteanu, Marius Cherciu, Olivia-Mihaela Popa   +9 more
doaj   +2 more sources

Unveiling the impact of ERAP1 and ERAP2 on migration, angiogenesis and ER stress response [PDF]

Frontiers in Cell and Developmental Biology
Recent studies have investigated the key roles exerted by ERAP1 and ERAP2 in maintaining cellular homeostasis, emphasizing their functions beyond traditional antigen processing and presentation.
Irma Saulle, Irma Saulle, Alessandra Velia Vitalyos, Daniel D’Agate, Mario Clerici, Mario Clerici, Mara Biasin   +6 more
doaj   +2 more sources

The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis [PDF]

BMC Infectious Diseases
Background Genetic variations in endoplasmic reticulum aminopeptidase (ERAP1, ERAP2) genes are associated with the pathogenesis of multiple diseases, including infectious diseases.
Shi-Hong Su, Xue-Qian Cai, Yong-Huai Li, Ai-Hui Xu, Qian Huang, Hua Niu, Qing-Hai You, Geng-Yun Sun   +7 more
doaj   +2 more sources

Estimation of endoplasmic reticulum aminopeptidase 1 level of expression in lesional and nonlesional skin of psoriatic patients and healthy controls

Journal of the Egyptian Women’s Dermatologic Society, 2021
Background Psoriasis is a chronic inflammatory autoimmune disease of the skin, in which an elevated expression of endoplasmic reticulum aminopeptidase 1 (ERAP1), an enzyme involved in the final processing of major histocompatibility complex-I ligands ...
Dina Metwally, Laila A Rashed, Amul M Badr, Doaa M Elqadi, Rana F Hilal   +4 more
doaj   +1 more source

Endoplasmic Reticulum Aminopeptidase 1 Is Involved in Anti-viral Immune Response of Hepatitis B Virus by Trimming Hepatitis B Core Antigen to Generate 9-Mers Peptides

Frontiers in Microbiology, 2022
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a processing enzyme of antigenic peptides presented to major histocompatibility complex (MHC) class I molecules.
Huanhuan Liu, Bingqi Hu, Junfeng Huang, Qin Wang, Feier Wang, Faming Pan, Liwen Chen   +6 more
doaj   +1 more source

ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function

Frontiers in Immunology, 2021
The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by major histocompatibility complex (MHC) class I molecules.
Silvia D’Amico, Valerio D’Alicandro, Mirco Compagnone, Patrizia Tempora, Giusy Guida, Paolo Romania, Valeria Lucarini, Ombretta Melaiu, Michela Falco, Mattia Algeri, Daniela Pende, Loredana Cifaldi, Loredana Cifaldi, Doriana Fruci   +13 more
doaj   +1 more source