Results 1 to 10 of about 202 (113)

Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma [PDF]

Analytical Cellular Pathology, 2015
The antigen processing machinery (APM) plays an important role in immune recognition of virally infected and transformed cells. Defective expression of the APM component ERAP1 is associated with progression and poor clinical outcome in cervical carcinoma.
Akash M. Mehta, Michelle Osse, Sandra Kolkman-Uljee, Gert Jan Fleuren, Ekaterina S. Jordanova   +4 more
doaj   +5 more sources

Expression and role of ERAP1 in placental tissues of preeclampsia

Hypertension in Pregnancy, 2020
Objective This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis. Methods ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot.
Yanyan Xu, Junjiao Wu, Jianbo Wu
doaj   +3 more sources

The impact of ERAP1 inhibition on metabolite homeostasis of melanoma cells

Scientific Reports
Manipulation of the activity of Endoplasmic Reticulum AminoPeptidase 1 (ERAP1) has emerged as a powerful tool for the modulation of the cellular antigenicity and concomitant adaptive immune responses, with potential applications in cancer immunotherapy ...
Aroosha Raja, Martha Nikopaschou, Joke H. de Boer, Jeannette Ossewaarde-van Norel, Anna Artati, Michael Witting, Efstratios Stratikos, Jonas J. W. Kuiper   +7 more
doaj   +3 more sources

ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes

Immunology, Volume 177, Issue 2, Page 398-412, February 2026.
ERAP1 is an intracellular aminopeptidase that edits antigenic peptides to be presented by MHC class I molecules and is found in distinct functional allotypes in individuals. To investigate how different disease‐associated ERAP1 allotypes affect the cellular immunopeptidome, we generated A375 melanoma cell clones carrying either allotype 2 or allotype ...
Martha Nikopaschou, Martina Samiotaki, Anna Kannavou, Nikolaos V. Angelis, Ourania Tsitsilonis, George Panayotou, Efstratios Stratikos   +6 more
wiley   +3 more sources

The Role of Aminopeptidase ERAP1 in Human Pathology—A Review

Current Issues in Molecular Biology
Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic
Laura Țiburcă, Dana Carmen Zaha, Maria Claudia Jurca, Emilia Severin, Aurora Jurca, Alexandru Daniel Jurca   +5 more
doaj   +3 more sources

Functional ERAP1 Variants Distinctively Associate with Ankylosing Spondylitis Susceptibility under the Influence of HLA-B27 in Taiwanese

Cells, 2022
Epistasis of ERAP1 single nucleotide variations (SNVs) and HLA-B27 has been linked to ankylosing spondylitis susceptibility (AS). The current study examined how prevalent ERAP1 allelic variants (SNV haplotypes) in Taiwan affect ERAP1 functions and AS ...
Chin-Man Wang, Ming-Kun Liu, Yeong-Jian Jan Wu, Jing-Chi Lin, Jian-Wen Zheng, Jianming Wu, Ji-Yih Chen   +6 more
doaj   +1 more source

Estimation of endoplasmic reticulum aminopeptidase 1 level of expression in lesional and nonlesional skin of psoriatic patients and healthy controls

Journal of the Egyptian Women’s Dermatologic Society, 2021
Background Psoriasis is a chronic inflammatory autoimmune disease of the skin, in which an elevated expression of endoplasmic reticulum aminopeptidase 1 (ERAP1), an enzyme involved in the final processing of major histocompatibility complex-I ligands ...
Dina Metwally, Laila A Rashed, Amul M Badr, Doaa M Elqadi, Rana F Hilal   +4 more
doaj   +1 more source

Endoplasmic Reticulum Aminopeptidase 1 Is Involved in Anti-viral Immune Response of Hepatitis B Virus by Trimming Hepatitis B Core Antigen to Generate 9-Mers Peptides

Frontiers in Microbiology, 2022
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a processing enzyme of antigenic peptides presented to major histocompatibility complex (MHC) class I molecules.
Huanhuan Liu, Bingqi Hu, Junfeng Huang, Qin Wang, Feier Wang, Faming Pan, Liwen Chen   +6 more
doaj   +1 more source

ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function

Frontiers in Immunology, 2021
The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by major histocompatibility complex (MHC) class I molecules.
Silvia D’Amico, Valerio D’Alicandro, Mirco Compagnone, Patrizia Tempora, Giusy Guida, Paolo Romania, Valeria Lucarini, Ombretta Melaiu, Michela Falco, Mattia Algeri, Daniela Pende, Loredana Cifaldi, Loredana Cifaldi, Doriana Fruci   +13 more
doaj   +1 more source

The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I

Scientific Reports, 2021
Processing of N-terminally elongated antigenic peptide precursors by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key step in antigen presentation and the adaptive immune response.
George Mavridis, Anastasia Mpakali, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou, Eleni Kaloumenou, Angeliki Ziotopoulou, Dimitris Georgiadis, Athanasios Papakyriakou, Efstratios Stratikos   +9 more
doaj   +1 more source