Results 31 to 40 of about 3,350 (175)

ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses

BMC Immunology, 2022
Background In addition to its role in antigen presentation, recent reports establish a new role for endoplasmic reticulum aminopeptidase 1 (ERAP1) in innate immunity; however, the mechanisms underlying these functions are not fully defined. We previously
Maja K. Blake, Patrick O’Connell, Yuliya Pepelyayeva, Sarah Godbehere, Yasser A. Aldhamen, Andrea Amalfitano   +5 more
doaj   +1 more source

ERAP1 Gen İfadesinin Plazma Hücre Diskrazilerinde İncelenmesi

, 2022
Amaç: Önemi bilinmeyen monoklonal gammopati asemptomatik, multipl miyeloma ise semptomatik bir plazma hücre diskrazisidir. Daha önce yaptığımız RNA dizileme çalışmasında multipl miyeloma hastalarında endoplazmik retikulum aminopeptidaz 1 (ERAP1) geninin ...
Sarıman, Melda, Abacı, Neslihan, Palanduz, Şükrü, Ayer, Mesut, Öztürk, Şükrü, Sırma Ekmekci, Sema, Nalçacı, Meliha, Çefle, Kıvanç, Suer, İlknur, Karaçam, Büşra   +9 more
core   +1 more source

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation

Frontiers in Immunology, 2022
Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou, Anastasia Mpakali, Efstratios Stratikos, Efstratios Stratikos   +3 more
doaj   +1 more source

Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism

Nature Communications, 2021
The endoplasmic-reticulum aminopeptidase ERAP1 processes peptides for antigen presentation. Here, the authors assess ERAP1 conformational states in solution, providing insight into the molecular mechanisms of ERAP1 substrate-length dependent catalytic ...
Zachary Maben, Richa Arya, Dimitris Georgiadis, Efstratios Stratikos, Lawrence J. Stern   +4 more
doaj   +1 more source

Shedding Light on the Role of ERAP1 in Axial Spondyloarthritis

Cureus, 2023
Spondyloarthritis (SpA) is a multifactorial chronic inflammatory disease affecting the axial skeleton (axSpA) and/or peripheral joints (p-SpA) and entheses. The disease's pathogenesis depends on genetic, immunological, mechanical, and environmental factors.
Saad, Mohamed A, Abdul-Sattar, Amal B, Abdelal, Ibrahim T, Baraka, Ahmed   +3 more
openaire   +2 more sources

ERAP1 biology and assessment in Ankylosing Spondylitis [PDF]

Proceedings of the National Academy of Sciences, 2015
We read with interest the work of Reeves et al. on endoplasmic reticulum aminopeptidase 1 (ERAP1) haplotypes found in Ankylosing Spondylitis (AS), and have several concerns about the study and its conclusions (1).
Robinson, Philip C., Brown, Matthew A.
openaire   +5 more sources

The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities

Frontiers in Immunology, 2022
IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban, Adrian Martín-Esteban, Jesus Contreras Rodriguez, David Peske, Jose A. Lopez de Castro, Nilabh Shastri, Scheherazade Sadegh-Nasseri   +6 more
doaj   +1 more source

Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis [PDF]

, 2014
The mechanism by which human leukocyte antigen B27 (HLA-B27) contributes to ankylosing spondylitis (AS) remains unclear. Genetic studies demonstrate that association with and interaction between polymorphisms of endoplasmic reticulum aminopeptidase 1 ...
Robinson, P. C., Low, PL, R Alessandro, M A Brown, Kenna, T.J., G Triolo, M C Lau, Brown, M. A., P Keith, N Agrawal, Keith, P, Robinson, PC, Low, P. -L., Lau, M.C., T J Kenna, Thomas, G.P., P-L Low, Agrawal, N., Bradbury, L, Low, P.L., Kenna, T. J., M-E Costello, P C Robinson, Costello, M. -E., Keith, P., TRIOLO, Giovanni, Ciccia, F., Costello, M.E., L Bradbury, Bradbury, L., Kenna,TJ, Thomas, G. P., Agrawal, N, Robinson, P.C., Lau, MC, Brown, MA, Lau, M. C., Bradbury, L.A., Brown, M.A., Alessandro, R., Costello, ME, CICCIA, Francesco, ALESSANDRO, Riccardo, G P Thomas, F Ciccia, Thomas, GP, Triolo, G.   +46 more
core   +1 more source

The design, synthesis and optimisation of small molecule ERAP1 inhibitors

, 2022
Previously held under moratorium in the Chemistry Department (GSK) from 1st February 2023 until 4th March 2025. The confidentiality statement in this thesis does not apply.Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is an intracellular aminopeptidase ...
Hryczanek, Ross Peter
core   +2 more sources

The role of ERAP1 and HLA-B27 in ankylosing spondylitis pathogenesis [PDF]

, 2013
HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondylitis (AS). As a key aminopeptidase in MHC class I presentation, ERAP1 potentially contributes to AS pathogenesis through altering HLA-B27 peptide presentation.
Bowness, Paul, Kollnberger, Simon, Chen, Liye   +2 more
core   +2 more sources