Results 31 to 40 of about 3,465 (162)
Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis. [PDF]
, 2015 Objective Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly associated with ankylosing spondylitis (AS).
Bowness, Paul +11 more
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ERAP1 inhibitor development [PDF]
, 2018 ERAP1 has been associated with a set of immune-mediated diseases, including ankylosing spondylitis. Currently, there is no selective and potent ERAP1 inhibitor available that would allow in-depth research of its functions and roles in diseases. Therefore,
core +1 more source
Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma
Analytical Cellular Pathology, 2015 The antigen processing machinery (APM) plays an important role in immune recognition of virally infected and transformed cells. Defective expression of the APM component ERAP1 is associated with progression and poor clinical outcome in cervical carcinoma.
Akash M. Mehta +4 more
doaj +1 more source
The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Frontiers in Immunology, 2022 IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban +6 more
doaj +1 more source
The role of ERAP1 and HLA-B27 in ankylosing spondylitis pathogenesis [PDF]
, 2016 HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondylitis (AS). As a key aminopeptidase in MHC class I presentation, ERAP1 potentially contributes to AS pathogenesis through altering HLA-B27 peptide presentation.
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The design, synthesis and optimisation of small molecule ERAP1 inhibitors
, 2022 Previously held under moratorium in the Chemistry Department (GSK) from 1st February 2023 until 4th March 2025. The confidentiality statement in this thesis does not apply.Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is an intracellular aminopeptidase ...
Hryczanek, Ross Peter
core +2 more sources
Allele frequencies of 11 ERAP1 SNPs.
, 2020 Allele frequencies of 11 ERAP1 SNPs.
Parisa Riahi (8407764) +9 more
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Cell Reports, 2017 Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3′ UTR,
Paolo Romania +22 more
doaj +1 more source
Scientific Reports, 2021 The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown.
Leonardo Capistrano Ferreira +6 more
doaj +1 more source
BMC Cancer, 2020 Background Antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that polymorphisms in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins and ...
Chuanyin Li +9 more
doaj +1 more source