Results 21 to 30 of about 3,465 (162)

Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response. [PDF]

PLoS ONE, 2013
Endoplasmic reticulum aminopeptidase-1 (ERAP1) is a multifunctional, ubiquitously expressed enzyme whose peptide-trimming role during antigen processing for presentation by MHC I molecules is well established, however, a role for ERAP1 in modulating ...
Yasser A Aldhamen, Sergey S Seregin, David P W Rastall, Charles F Aylsworth, Yuliya Pepelyayeva, Christopher J Busuito, Sarah Godbehere-Roosa, Sungjin Kim, Andrea Amalfitano   +8 more
doaj   +1 more source

Down-regulation of ERAP1 mRNA expression in non-small cell lung cancer

BMC Cancer, 2023
Background ERAP1 is a major aminopeptidase that serves as an editor of the peptide repertoire by trimming N-terminal residues of antigenic peptides, creating a pool of peptides with the optimal length for MHC-I binding.
Marta Wagner, Maciej Sobczyński, Monika Jasek, Konrad Pawełczyk, Irena Porębska, Piotr Kuśnierczyk, Andrzej Wiśniewski   +6 more
doaj   +1 more source

Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis

Türk Biyokimya Dergisi, 2022
Endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphic changes cause autoimmunity. To understand the contribution of ERAP1 to the occurrence of rheumatoid arthritis (RA) disease, we investigated the relationship between ERAP1 and RA.
Akbulut Ekrem, Yıldırım Tülay, Öztürk Onur   +2 more
doaj   +1 more source

ERAP1 Gen İfadesinin Plazma Hücre Diskrazilerinde İncelenmesi

, 2022
Amaç: Önemi bilinmeyen monoklonal gammopati asemptomatik, multipl miyeloma ise semptomatik bir plazma hücre diskrazisidir. Daha önce yaptığımız RNA dizileme çalışmasında multipl miyeloma hastalarında endoplazmik retikulum aminopeptidaz 1 (ERAP1) geninin ...
Sarıman, Melda, Abacı, Neslihan, Palanduz, Şükrü, Ayer, Mesut, Öztürk, Şükrü, Sırma Ekmekci, Sema, Nalçacı, Meliha, Çefle, Kıvanç, Suer, İlknur, Karaçam, Büşra   +9 more
core   +1 more source

ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses

BMC Immunology, 2022
Background In addition to its role in antigen presentation, recent reports establish a new role for endoplasmic reticulum aminopeptidase 1 (ERAP1) in innate immunity; however, the mechanisms underlying these functions are not fully defined. We previously
Maja K. Blake, Patrick O’Connell, Yuliya Pepelyayeva, Sarah Godbehere, Yasser A. Aldhamen, Andrea Amalfitano   +5 more
doaj   +1 more source

Multifactor dimensionality reduction reveals the effect of interaction between ERAP1 and IFIH1 polymorphisms in psoriasis susceptibility genes

Frontiers in Genetics, 2022
Background: Psoriasis is a common immune-mediated hyperproliferative skin dysfunction with known genetic predisposition. Gene–gene interaction (e.g., between HLA-C and ERAP1) in the psoriasis context has been reported in various populations. As ERAP1 has
Chang Zhang, Chang Zhang, Chang Zhang, Chang Zhang, Chang Zhang, Qin Qin, Qin Qin, Qin Qin, Qin Qin, Qin Qin, Yuanyuan Li, Yuanyuan Li, Yuanyuan Li, Yuanyuan Li, Yuanyuan Li, Xiaodong Zheng, Xiaodong Zheng, Xiaodong Zheng, Xiaodong Zheng, Xiaodong Zheng, Weiwei Chen, Weiwei Chen, Weiwei Chen, Weiwei Chen, Weiwei Chen, Qi Zhen, Qi Zhen, Qi Zhen, Qi Zhen, Qi Zhen, Bao Li, Bao Li, Bao Li, Bao Li, Bao Li, Wenjun Wang, Wenjun Wang, Wenjun Wang, Wenjun Wang, Wenjun Wang, Liangdan Sun, Liangdan Sun, Liangdan Sun, Liangdan Sun, Liangdan Sun   +44 more
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ERAP1 as an emerging therapeutic target for medulloblastoma

, 2022
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors,
Bufalieri F., Fruci D., Di Marcotullio L.   +2 more
core   +1 more source

Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis [PDF]

, 2014
The mechanism by which human leukocyte antigen B27 (HLA-B27) contributes to ankylosing spondylitis (AS) remains unclear. Genetic studies demonstrate that association with and interaction between polymorphisms of endoplasmic reticulum aminopeptidase 1 ...
Robinson, P. C., Low, PL, R Alessandro, M A Brown, Kenna, T.J., G Triolo, M C Lau, Brown, M. A., P Keith, N Agrawal, Keith, P, Robinson, PC, Low, P. -L., Lau, M.C., T J Kenna, Thomas, G.P., P-L Low, Agrawal, N., Bradbury, L, Low, P.L., Kenna, T. J., M-E Costello, P C Robinson, Costello, M. -E., Keith, P., TRIOLO, Giovanni, Ciccia, F., Costello, M.E., L Bradbury, Bradbury, L., Kenna,TJ, Thomas, G. P., Agrawal, N, Robinson, P.C., Lau, MC, Brown, MA, Lau, M. C., Bradbury, L.A., Brown, M.A., Alessandro, R., Costello, ME, CICCIA, Francesco, ALESSANDRO, Riccardo, G P Thomas, F Ciccia, Thomas, GP, Triolo, G.   +46 more
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Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism

Nature Communications, 2021
The endoplasmic-reticulum aminopeptidase ERAP1 processes peptides for antigen presentation. Here, the authors assess ERAP1 conformational states in solution, providing insight into the molecular mechanisms of ERAP1 substrate-length dependent catalytic ...
Zachary Maben, Richa Arya, Dimitris Georgiadis, Efstratios Stratikos, Lawrence J. Stern   +4 more
doaj   +1 more source

Investigating the genetic association between ERAP1 and ankylosing spondylitis. [PDF]

, 2009
A strong association between ERAP1 and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Australo-Anglo-American Spondylitis Consortium (WTCCC-TASC) study.
Evans, D. M., Roger D. Sturrock, Matthew A. Brown, Claire Farrar, Jennifer J. Pointon, Appleton, L. H., Brown, Matthew A., David M. Evans, Wordsworth, B. P., Louise H. Appleton, B. Paul Wordsworth, Oppermann, U., Tugce Karaderi, Karaderi, T., David Harvey, Millicent A. Stone, Pointon, J. J., Farrar, C., Stone, M. A., Udo Oppermann, Harvey, D., Sturrock, R. D.   +21 more
core   +1 more source