Results 21 to 30 of about 5,215 (208)

The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I

Scientific Reports, 2021
Processing of N-terminally elongated antigenic peptide precursors by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key step in antigen presentation and the adaptive immune response.
George Mavridis, Anastasia Mpakali, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou, Eleni Kaloumenou, Angeliki Ziotopoulou, Dimitris Georgiadis, Athanasios Papakyriakou, Efstratios Stratikos   +9 more
doaj   +1 more source

Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis

Türk Biyokimya Dergisi, 2022
Endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphic changes cause autoimmunity. To understand the contribution of ERAP1 to the occurrence of rheumatoid arthritis (RA) disease, we investigated the relationship between ERAP1 and RA.
Akbulut Ekrem, Yıldırım Tülay, Öztürk Onur   +2 more
doaj   +1 more source

Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis [PDF]

, 2012
Functional severity in ankylosing spondylitis (AS) patients is variable and difficult to predict early. The aim of our study was to assess whether a combination of baseline clinical factors and genetic markers may predict the development of severe ...
Artieda, Marta, Bartolomé, Nerea, Buzoianu, Anca Dana, Collantes Estévez, Eduardo Collantes, Cuende, Eduardo, Martínez, Antonio Plaza, Mulero Mendoza, Juan, Sanz, Jesús Sanz, Schiotis, Ruxandra Elena, Szczypiorska, Magdalena, Sánchez, Alejandra, Tejedor, Diego   +11 more
core   +18 more sources

Druggable genome‐wide Mendelian randomization analysis identifies potential treatment targets in vascular dementia [PDF]

Alzheimers Dement (N Y)
Abstract BACKGROUND There are currently no US Food and Drug Administration‐approved treatments for vascular dementia (VaD). Genome‐wide approaches have successfully identified druggable targets and treatments for various disorders. In this study, we performed druggable genome‐wide two‐sample Mendelian randomization (2SMR) analysis to identify possible ...
Lennon M, Xu Y, Thalamuthu A, Mather K, Sachdev P.   +4 more
europepmc   +2 more sources

ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency [PDF]

The Journal of Immunology, 2014
Abstract The endoplasmic reticulum aminopeptidases (ERAP)1 and ERAP2 play a critical role in the production of final epitopes presented by MHC class I molecules. Formation of heterodimers by ERAP1 and ERAP2 has been proposed to facilitate trimming of epitope precursor peptides, but the effects of dimerization on ERAP function remain ...
Irini, Evnouchidou, Mirjana, Weimershaus, Loredana, Saveanu, Peter, van Endert   +3 more
openaire   +2 more sources

Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response. [PDF]

PLoS ONE, 2013
Endoplasmic reticulum aminopeptidase-1 (ERAP1) is a multifunctional, ubiquitously expressed enzyme whose peptide-trimming role during antigen processing for presentation by MHC I molecules is well established, however, a role for ERAP1 in modulating ...
Yasser A Aldhamen, Sergey S Seregin, David P W Rastall, Charles F Aylsworth, Yuliya Pepelyayeva, Christopher J Busuito, Sarah Godbehere-Roosa, Sungjin Kim, Andrea Amalfitano   +8 more
doaj   +1 more source

ERAP1 biology and assessment in Ankylosing Spondylitis [PDF]

Proceedings of the National Academy of Sciences, 2015
We read with interest the work of Reeves et al. on endoplasmic reticulum aminopeptidase 1 (ERAP1) haplotypes found in Ankylosing Spondylitis (AS), and have several concerns about the study and its conclusions (1).
Robinson, Philip C., Brown, Matthew A.
openaire   +3 more sources

Down-regulation of ERAP1 mRNA expression in non-small cell lung cancer

BMC Cancer, 2023
Background ERAP1 is a major aminopeptidase that serves as an editor of the peptide repertoire by trimming N-terminal residues of antigenic peptides, creating a pool of peptides with the optimal length for MHC-I binding.
Marta Wagner, Maciej Sobczyński, Monika Jasek, Konrad Pawełczyk, Irena Porębska, Piotr Kuśnierczyk, Andrzej Wiśniewski   +6 more
doaj   +1 more source

Multifactor dimensionality reduction reveals the effect of interaction between ERAP1 and IFIH1 polymorphisms in psoriasis susceptibility genes

Frontiers in Genetics, 2022
Background: Psoriasis is a common immune-mediated hyperproliferative skin dysfunction with known genetic predisposition. Gene–gene interaction (e.g., between HLA-C and ERAP1) in the psoriasis context has been reported in various populations. As ERAP1 has
Chang Zhang, Chang Zhang, Chang Zhang, Chang Zhang, Chang Zhang, Qin Qin, Qin Qin, Qin Qin, Qin Qin, Qin Qin, Yuanyuan Li, Yuanyuan Li, Yuanyuan Li, Yuanyuan Li, Yuanyuan Li, Xiaodong Zheng, Xiaodong Zheng, Xiaodong Zheng, Xiaodong Zheng, Xiaodong Zheng, Weiwei Chen, Weiwei Chen, Weiwei Chen, Weiwei Chen, Weiwei Chen, Qi Zhen, Qi Zhen, Qi Zhen, Qi Zhen, Qi Zhen, Bao Li, Bao Li, Bao Li, Bao Li, Bao Li, Wenjun Wang, Wenjun Wang, Wenjun Wang, Wenjun Wang, Wenjun Wang, Liangdan Sun, Liangdan Sun, Liangdan Sun, Liangdan Sun, Liangdan Sun   +44 more
doaj   +1 more source

The role of polymorphic ERAP1 in autoinflammatory disease [PDF]

Bioscience Reports, 2018
Autoimmune and autoinflammatory conditions represent a group of disorders characterized by self-directed tissue damage due to aberrant changes in innate and adaptive immune responses. These disorders possess widely varying clinical phenotypes and etiology; however, they share a number of similarities in genetic associations and environmental influences.
Reeves, Emma, James, Edward
openaire   +5 more sources