Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity [PDF]
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha +2 more
wiley +2 more sources
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP [PDF]
Nature Communications, 2019 ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from βTrCP and promoting tumorigenesis through βTrCP ...
Francesca Bufalieri +26 more
doaj +8 more sources
The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis [PDF]
BMC Infectious DiseasesBackground Genetic variations in endoplasmic reticulum aminopeptidase (ERAP1, ERAP2) genes are associated with the pathogenesis of multiple diseases, including infectious diseases.
Shi-Hong Su +7 more
doaj +2 more sources
Unveiling the impact of ERAP1 and ERAP2 on migration, angiogenesis and ER stress response [PDF]
Frontiers in Cell and Developmental BiologyRecent studies have investigated the key roles exerted by ERAP1 and ERAP2 in maintaining cellular homeostasis, emphasizing their functions beyond traditional antigen processing and presentation.
Irma Saulle +6 more
doaj +2 more sources
Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population [PDF]
Frontiers in ImmunologyIntroductionRheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II, nevertheless some HLA class I associations have also been observed.
Iryna Kril +8 more
doaj +2 more sources
Frontiers in Immunology, 2021 Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components.
Andrzej Wiśniewski +10 more
doaj +1 more source
Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response. [PDF]
PLoS ONE, 2013 Endoplasmic reticulum aminopeptidase-1 (ERAP1) is a multifunctional, ubiquitously expressed enzyme whose peptide-trimming role during antigen processing for presentation by MHC I molecules is well established, however, a role for ERAP1 in modulating ...
Yasser A Aldhamen +8 more
doaj +1 more source
Down-regulation of ERAP1 mRNA expression in non-small cell lung cancer
BMC Cancer, 2023 Background ERAP1 is a major aminopeptidase that serves as an editor of the peptide repertoire by trimming N-terminal residues of antigenic peptides, creating a pool of peptides with the optimal length for MHC-I binding.
Marta Wagner +6 more
doaj +1 more source
Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis
Türk Biyokimya Dergisi, 2022 Endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphic changes cause autoimmunity. To understand the contribution of ERAP1 to the occurrence of rheumatoid arthritis (RA) disease, we investigated the relationship between ERAP1 and RA.
Akbulut Ekrem +2 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: Psoriasis is a common immune-mediated hyperproliferative skin dysfunction with known genetic predisposition. Gene–gene interaction (e.g., between HLA-C and ERAP1) in the psoriasis context has been reported in various populations. As ERAP1 has
Chang Zhang +44 more
doaj +1 more source