Results 41 to 50 of about 5,215 (208)

Investigating the genetic association between ERAP1 and ankylosing spondylitis [PDF]

Human Molecular Genetics, 2009
A strong association between ERAP1 and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Australo-Anglo-American Spondylitis Consortium (WTCCC-TASC) study. ERAP1 is highly polymorphic with strong linkage disequilibrium evident across the gene.
Harvey, David, Pointon, Jennifer J., Evans, David M., Karaderi, Tugce, Farrar, Claire, Appleton, Louise H., Sturrock, Roger D., Stone, Millicent A., Oppermann, Udo, Brown, Matthew A., Wordsworth, B. Paul   +10 more
openaire   +3 more sources

ERAP1 in ankylosing spondylitis

Current Opinion in Rheumatology, 2013
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an aminopeptidase of the endoplasmic reticulum involved in trimming of peptides to their optimal size for binding to major histocompatibility complex class I molecules. Natural ERAP1 polymorphism resulting in altered enzymatic activity is associated with ankylosing spondylitis, an inflammatory disorder ...
Álvarez-Navarro, Carlos, López de Castro, José A.   +1 more
openaire   +3 more sources

Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 peptidome through differential processing determined by multiple peptide residues [PDF]

, 2016
Copyright © 2015 by the American College of Rheumatology. Objective To characterize the alterations, as well as their mechanisms, induced in the HLA-B27-bound peptidome expressed in live cells by the natural ERAP1 polymorphisms predisposing to ankylosing
Akram, Alvarez-Navarro, Andres, Brown, Burton, Calvo, Chang, Chen, Constantino, Cortes, Ellis, Evans, Evnouchidou, Evnouchidou, Garcia-Medel, Garcia-Medel, Garcia-Medel, Goto, Haroon, Harvey, Hearn, James, Kirino, Kochan, Manz, Marcilla, Martin-Esteban, Nguyen, Paradela, Paradela, Reeves, Saric, Seregin, Serwold, Strange, Zemmour   +35 more
core   +1 more source

Shedding Light on the Role of ERAP1 in Axial Spondyloarthritis

Cureus, 2023
Spondyloarthritis (SpA) is a multifactorial chronic inflammatory disease affecting the axial skeleton (axSpA) and/or peripheral joints (p-SpA) and entheses. The disease's pathogenesis depends on genetic, immunological, mechanical, and environmental factors.
Saad, Mohamed A, Abdul-Sattar, Amal B, Abdelal, Ibrahim T, Baraka, Ahmed   +3 more
openaire   +2 more sources

A cautionary note on the impact of protocol changes for Genome-Wide Association SNP x SNP Interaction studies: an example on ankylosing spondylitis [PDF]

, 2015
Genome-wide association interaction (GWAI) studies have increased in popularity. Yet to date, no standard protocol exists. In practice, any GWAI workflow involves making choices about quality control strategy, SNP filtering, linkage disequilibrium (LD)
Bessonov, Kyrylo, Gusareva, Elena, Van Steen, Kristel   +2 more
core   +1 more source

Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface [PDF]

, 2018
HLA-B*27:05 is associated with the development of autoimmune spondyloarthropathies, but the precise causal relationship between the MHC haplotype and disease pathogenesis is yet to be elucidated. Studies focusing on the structure and cellular trafficking
Abualrous, Esam Tolba, Borchert, Britta, Hein, Zeynep, Springer, Sebastian   +3 more
core   +2 more sources

Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women

Scientific Reports, 2021
The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown.
Leonardo Capistrano Ferreira, Carlos Eduardo Maia Gomes, Priya Duggal, Ingrid De Paula Holanda, Amanda Samara de Lima, Paulo Ricardo Porfírio do Nascimento, Selma Maria Bezerra Jeronimo   +6 more
doaj   +1 more source

Strucutral Characterization of ER aminopeptidase, ERAP1

The FASEB Journal, 2006
The endoplasmic reticulum (ER) aminopeptidase, ERAP1, is a 941 amino acid member of the M1 family of zinc metalloaminopeptidases. Unlike other aminopeptidases, ERAP1 exhibits a substrate length preference and a C‐terminal residue preference. ERAP1 has been suggested to have a molecular ruler mechanism because it trims peptides to lengths (8 or 9 amino ...
Tina T Nguyen, Lawrence J Stern
openaire   +1 more source

Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population

BMC Cancer, 2020
Background Antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that polymorphisms in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins and ...
Chuanyin Li, Yaheng Li, Zhiling Yan, Shuying Dai, Shuyuan Liu, Xia Wang, Jun Wang, Xinwen Zhang, Li Shi, Yufeng Yao   +9 more
doaj   +1 more source

To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2

Frontiers in Immunology, 2022
To be, or not to be, that is the question. (William Shakespeare, Hamlet)Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2, respectively) play a role in trimming peptides that are too long to be bound and presented by class I HLA (HLA-I ...
Piotr Kuśnierczyk
doaj   +1 more source