Results 41 to 50 of about 3,350 (175)

Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion

Cell Reports, 2017
Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3′ UTR,
Paolo Romania, Loredana Cifaldi, Benedetta Pignoloni, Nadia Starc, Valerio D’Alicandro, Ombretta Melaiu, Giuseppina Li Pira, Ezio Giorda, Rosalba Carrozzo, Monika Bergvall, Tomas Bergström, Lars Alfredsson, Tomas Olsson, Ingrid Kockum, Ilkka Seppälä, Terho Lehtimäki, Mikko A. Hurme, Hartmut Hengel, Angela Santoni, Cristina Cerboni, Franco Locatelli, Mauro D’Amato, Doriana Fruci   +22 more
doaj   +1 more source

Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women

Scientific Reports, 2021
The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown.
Leonardo Capistrano Ferreira, Carlos Eduardo Maia Gomes, Priya Duggal, Ingrid De Paula Holanda, Amanda Samara de Lima, Paulo Ricardo Porfírio do Nascimento, Selma Maria Bezerra Jeronimo   +6 more
doaj   +1 more source

Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population

BMC Cancer, 2020
Background Antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that polymorphisms in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins and ...
Chuanyin Li, Yaheng Li, Zhiling Yan, Shuying Dai, Shuyuan Liu, Xia Wang, Jun Wang, Xinwen Zhang, Li Shi, Yufeng Yao   +9 more
doaj   +1 more source

ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations

, 2017
We investigated the proposal that ankylosing spondylitis (AS) is associated with unusual ERAP1 genotypes. ERAP1 haplotypes were constructed for 213 AS cases and 46 rheumatoid arthritis controls using family data.
Vecellio, M, Watts, L, Wordsworth, Paul, Vecellio, Matteo, Wordsworth, B, Lau, J, Appleton, Louise H., Brown, MA, Roberts, AR, Watts, Laura, Brown, Matthew A., Appleton, LH, Lau, Jonathan, Cortes, A, Cortes, Adrian, Roberts, Amity R., Wordsworth, Bryan   +16 more
core   +1 more source

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia

Frontiers in Immunology, 2020
Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta.
Kimberly Seamon, Lesia O. Kurlak, Michelle Warthan, Efstratios Stratikos, Jerome F. Strauss, Hiten D. Mistry, Eun D. Lee, Eun D. Lee   +7 more
doaj   +1 more source

To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2

Frontiers in Immunology, 2022
To be, or not to be, that is the question. (William Shakespeare, Hamlet)Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2, respectively) play a role in trimming peptides that are too long to be bound and presented by class I HLA (HLA-I ...
Piotr Kuśnierczyk
doaj   +1 more source

The impact of ERAP1 functions on innate and adaptive immunity in human disease models

, 2022
ERAP1 has long been appreciated for its role in antigen presentation during the adaptive immune response. It is a peptidase in the endoplasmic reticulum that trims peptide antigens prior to their loading onto awaiting MHC-1.
Blake, Maja Kristin K.
core   +1 more source

A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

PLoS ONE, 2012
The ERAP1 gene encodes an aminopeptidase involved in antigen processing. A functional polymorphism in the gene (rs30187, Arg528Lys) associates with susceptibility to ankylosying spondylitis (AS), whereas a SNP in the interacting ERAP2 gene increases susceptibility to another inflammatory autoimmune disorder, Crohn's disease (CD). We analysed rs30187 in
F. R. Guerini, R. Cagliani, D. Forni, C. Agliardi, D. Caputo, A. Cassinotti, D. Galimberti, C. Fenoglio, M. Biasin, R. Asselta, E. Scarpini, G.P. Comi, N. Bresolin, M.S. Clerici, M. Sironi   +14 more
openaire   +6 more sources

ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency [PDF]

The Journal of Immunology, 2014
Abstract The endoplasmic reticulum aminopeptidases (ERAP)1 and ERAP2 play a critical role in the production of final epitopes presented by MHC class I molecules. Formation of heterodimers by ERAP1 and ERAP2 has been proposed to facilitate trimming of epitope precursor peptides, but the effects of dimerization on ERAP function remain ...
Irini, Evnouchidou, Mirjana, Weimershaus, Loredana, Saveanu, Peter, van Endert   +3 more
openaire   +2 more sources

The Role of Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) in the Pathogenesis of Ankylosing Spondylitis [PDF]

, 2012
Ankylosing spondylitis (AS) is associated with HLA-B*2704 and B*2705 but not with HLA-B*2706 and B*2709. Genome wide studies recently identified ERAP1 as an important genetic association in AS and could be the missing link in the pathogenesis of AS.
Haroon, Nigil
core   +2 more sources