Results 41 to 50 of about 3,465 (162)

Association of ERAP1 and IL23R gene polymorphisms with ankylosing spondylitis

Современная ревматология, 2020
Currently, the causes of extra-axial and extra-skeletal manifestations of ankylosing spondylitis (AS) and the possible impact of genetic aspects on its course and clinical features remain unresolved.Objective: to investigate the association of the ...
U. A. Yakubova, O. V. Bugrova, K. A. Nagornova   +2 more
doaj   +1 more source

To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2

Frontiers in Immunology, 2022
To be, or not to be, that is the question. (William Shakespeare, Hamlet)Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2, respectively) play a role in trimming peptides that are too long to be bound and presented by class I HLA (HLA-I ...
Piotr Kuśnierczyk
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

ERAP, KIR, and HLA-C Profile in Recurrent Implantation Failure

Frontiers in Immunology, 2021
The mother’s uterine immune system is dominated by uterine natural killer (NK) cells during the first trimester of pregnancy. These cells express killer cell immunoglobulin-like receptors (KIRs) of inhibitory or activating function. Invading extravillous
Karolina Piekarska, Paweł Radwan, Agnieszka Tarnowska, Andrzej Wiśniewski, Michał Radwan, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Andrzej Malinowski, Izabela Nowak   +9 more
doaj   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Endoplasmic reticulum aminopeptidase 1 (ERAP1) plays a critical role in determining the length and sequence of peptides bound and presented by HLA-B27 [PDF]

, 2016
Objective. HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondylitis (AS). A key aminopeptidase in MHC class I presentation, ERAP1 potentially contributes to AS pathogenesis through altering HLA-B27 peptide ...
Reeves, Emma, Bowness, Paul, Fischer, Roman, Shastri, Nilabh, James, Edward, Chen, Liye, Peng, Yanchun, Elliott, Tim, Ternette, Nicola, McHugh, Kirsty, Dong, Tao, Kollnberger, Simon, Hanke, Tomas   +12 more
core   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Human leukocyte antigen B polymorphism and association between HLA‐B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh

Rheumatology & Autoimmunity, 2022
Objectives To determine the association of Human leukocyte antigen B (HLA‑B) alleles with ankylosing spondylitis and the allelic association of HLA‐B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single‐nucleotide polymorphism (SNP) rs30187 in ...
Md Kamrul H. Sajib, Shamim Ahmed, Syed A. Haq, Minhaj R. Choudhury, Mohammed Uddin, Furkan Uddin, Muhammad S. A. Khan, Mohammad M. Zaman   +7 more
doaj   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1

SLAS Discovery, 2023
MALDI-TOF MS is a powerful analytical technique that provides a fast and label-free readout for in vitro assays in the high-throughput screening (HTS) environment.
Leonie Müller, Amy K Burton, Chloe L Tayler, James E Rowedder, Jonathan P Hutchinson, Simon Peace, Julie M Quayle, Melanie V Leveridge, Roland S Annan, Matthias Trost, Rachel E Peltier-Heap, Maria Emilia Dueñas   +11 more
doaj   +1 more source