Clinical and Experimental Hypertension, 2021 Objective To explore the correlation of polymorphisms of endoplasmic reticulum aminopeptidase-1 (ERAP-1) gene in Chinese women with preeclampsia.
Xiaowei Liu +2 more
exaly +4 more sources
Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response. [PDF]
PLoS ONE, 2013 Endoplasmic reticulum aminopeptidase-1 (ERAP1) is a multifunctional, ubiquitously expressed enzyme whose peptide-trimming role during antigen processing for presentation by MHC I molecules is well established, however, a role for ERAP1 in modulating ...
Yasser A Aldhamen +8 more
doaj +5 more sources
Association Study of Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 and 2 Genes in Iranian Women with Preeclampsia [PDF]
Iranian Journal of Public Health, 2019 Background: Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) are involved in blood pressure regulation and single nucleotide polymorphisms (SNPs) of these genes have been linked to preeclampsia. This study intended to assess the association of
Hamid DARGAHI +7 more
doaj +5 more sources
Endoplasmic Reticulum Aminopeptidase 1 Is Involved in Anti-viral Immune Response of Hepatitis B Virus by Trimming Hepatitis B Core Antigen to Generate 9-Mers Peptides [PDF]
Frontiers in Microbiology, 2022 Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a processing enzyme of antigenic peptides presented to major histocompatibility complex (MHC) class I molecules.
Huanhuan Liu +6 more
doaj +2 more sources
Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis
Türk Biyokimya Dergisi, 2022 Endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphic changes cause autoimmunity. To understand the contribution of ERAP1 to the occurrence of rheumatoid arthritis (RA) disease, we investigated the relationship between ERAP1 and RA.
Akbulut Ekrem +2 more
doaj +3 more sources
To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2
Frontiers in Immunology, 2022 To be, or not to be, that is the question. (William Shakespeare, Hamlet)Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2, respectively) play a role in trimming peptides that are too long to be bound and presented by class I HLA (HLA-I ...
Piotr Kuśnierczyk
exaly +3 more sources
Erratum: Endoplasmic reticulum aminopeptidase 1 is involved in anti-viral immune response of hepatitis B virus by trimming hepatitis B core antigen to generate 9-mers peptides [PDF]
Frontiers in Microbiology, 2023 Frontiers Production Office
doaj +2 more sources
Exploring the Involvement of ERAP1 in the Pathogenesis of Non-Infectious Uveitis: A Systematic Review [PDF]
LifeBackground: Non-infectious uveitis (NIU) is an inflammatory ocular condition often associated with systemic immune-mediated disorders. The pathogenesis of NIU is complex and involves genes from the Human Leukocyte Antigen (HLA) class I system ...
Ioana-Maria Rizea +9 more
doaj +2 more sources
The impact of ERAP1 inhibition on metabolite homeostasis of melanoma cells [PDF]
Scientific ReportsManipulation of the activity of Endoplasmic Reticulum AminoPeptidase 1 (ERAP1) has emerged as a powerful tool for the modulation of the cellular antigenicity and concomitant adaptive immune responses, with potential applications in cancer immunotherapy ...
Aroosha Raja +7 more
doaj +2 more sources
Autoimmune Disease-Associated Variants of Extracellular Endoplasmic Reticulum Aminopeptidase 1 Induce Altered Innate Immune Responses by Human Immune Cells [PDF]
Journal of Innate Immunity, 2015 Yuliya Pepelyayeva +2 more
exaly +2 more sources