Results 11 to 20 of about 6,017 (150)
Polymorphism of the Endoplasmic Reticulum Aminopeptidase 1 Gene in Egyptian Patients with Rheumatoid Arthritis [PDF]
Zagazig University Medical JournalBackground: Rheumatoid arthritis (RA) is a systemic autoimmune disease caused by the interplay of hereditary and environmental factors. Extreme polymorphism is assumed for the Endoplasmic Reticulum Aminopeptidase 1 Gene Polymorphism (ERAP1) gene.
Nora Said +4 more
doaj +2 more sources
Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. [PDF]
J Med Chem, 2020 ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex proteins. Here, we report discovery of the first inhibitors selective for ERAP1 over its paralogues ERAP2 and IRAP. Compound 1 (N-(N-(2-(1H-indol-3-yl)ethyl)carbamimidoyl)
Maben Z +13 more
europepmc +4 more sources
A Comparative Review of Pregnancy and Cancer and Their Association with Endoplasmic Reticulum Aminopeptidase 1 and 2. [PDF]
Int J Mol Sci, 2023 The fundamental basis of pregnancy and cancer is to determine the fate of the survival or the death of humanity. However, the development of fetuses and tumors share many similarities and differences, making them two sides of the same coin. This review presents an overview of the similarities and differences between pregnancy and cancer.
Hur B, Wong V, Lee ED.
europepmc +3 more sources
Iranian Journal of Allergy, Asthma and Immunology, 2012 Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27.
Mahdi Mahmoudi +8 more
doaj +2 more sources
Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1. [PDF]
Proc Natl Acad Sci U S A, 2019 Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that optimizes the peptide cargo of major histocompatibility class I (MHC-I) molecules and regulates adaptive immunity. It has unusual substrate selectivity for length and sequence, resulting in poorly understood effects on the cellular immunopeptidome.
Giastas P +9 more
europepmc +6 more sources
The role of Endoplasmic Reticulum Aminopeptidase 1(ERAP1) in Ankylosing Spondylitis
Indian Journal of Rheumatology, 2014 Abstract Ankylosing Spondylitis (AS) is an inflammatory arthritis that affects the spine resulting in significant deterioration in quality of life of patients as well as accounts for significant socio-economic burden. The etiology of AS is unresolved but appears to involve both environmental and genetic factors.
Hasan Abdullah, Nigil Haroon
doaj +2 more sources
Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation. [PDF]
Curr Opin Rheumatol, 2015 To review the recent developments in our understanding of endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) function in relation to its role in major histocompatibility complex (MHC) class I peptide presentation and human leukocyte antigen (HLA) class I-associated diseases.ERAP1 polymorphisms exhibiting loss-of-function have been associated with ...
Tran TM, Colbert RA.
europepmc +4 more sources
The association of endoplasmic reticulum aminopeptidase-1 (ERAP-1) with Familial Mediterranean Fever (FMF). [PDF]
United European Gastroenterol J, 2016 BackgroundThe ERAP1 gene cleaves the receptors and reduces their ability to transmit chemical signals to the cell that affect the process of inflammation and, secondly, it cleaves many types of proteins into small peptides that are recognized by the immune system.ObjectiveERAP‐1 gene mutations may create a sensitivity for Familial Mediterranean Fever ...
Sezgin G +5 more
europepmc +7 more sources
Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1. [PDF]
ACS Med Chem Lett, 2016 We employed virtual screening followed by in vitro evaluation to discover novel inhibitors of ER aminopeptidase 1, an important enzyme for the human adaptive immune response that has emerged as an attractive target for cancer immunotherapy and the control of autoimmunity. Screening hits included three structurally related compounds carrying the (E)-N'-(
Stamogiannos A +4 more
europepmc +5 more sources
Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis. [PDF]
Mol Med Rep, 2017 According to the results of the first genome-wide association study of ankylosing spondylitis (AS), endoplasmic reticulum aminopeptidase 1 (ERAP1) may serve an important role. However, a number of case-control studies have not been able to replicate this result using the same genetic markers. In the present study, the role of common genetic variants of
Wang X +7 more
europepmc +4 more sources