Results 31 to 40 of about 6,017 (150)

TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages [PDF]

The Journal of Immunology, 2014
Abstract Macrophages play an important role in host defense under several immunological, inflammatory, and/or infectious conditions. In our previous work, we demonstrated that endoplasmic reticulum aminopeptidase 1 (ERAP1) was secreted from macrophages in response to LPS and IFN-γ, and it enhanced their phagocytic activity. In this study,
Yoshikuni, Goto, Kenji, Ogawa, Takahiro J, Nakamura, Akira, Hattori, Masafumi, Tsujimoto   +4 more
openaire   +2 more sources

Concerted in vitro trimming of viral HLA-B27-restricted ligands by human ERAP1 and ERAP2 aminopeptidases. [PDF]

PLoS ONE, 2013
In the classical human leukocyte antigen (HLA) class I antigen processing and presentation pathway, the antigenic peptides are generated from viral proteins by multiple proteolytic cleavages of the proteasome (and in some cases other cytosolic proteases)
Elena Lorente, Alejandro Barriga, Carolina Johnstone, Carmen Mir, Mercedes Jiménez, Daniel López   +5 more
doaj   +1 more source

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

Frontiers in Cell and Developmental Biology, 2022
Ankylosing spondylitis (AS) or radiographic axial spondyloarthritis is a chronic immune-mediated rheumatic disorder characterized by the inflammation in the axial skeleton, peripheral joints, and soft tissues (enthesis, fascia, and ligament). In addition,
Hsien-Tzung Liao, Chang-Youh Tsai, Chien-Chih Lai, Song-Chou Hsieh, Yi-Syuan Sun, Ko-Jen Li, Chieh-Yu Shen, Cheng-Han Wu, Cheng-Hsun Lu, Yu-Min Kuo, Tzu-Hao Li, Tzu-Hao Li, Chung-Tei Chou, Chia-Li Yu   +13 more
doaj   +1 more source

The Role of Endoplasmic Reticulum-Associated Aminopeptidase 1 in Immunity to Infection and in Cross-Presentation [PDF]

The Journal of Immunology, 2007
Abstract Endoplasmic reticulum-associated aminopeptidase 1 (ERAP1) is involved in the final processing of endogenous peptides presented by MHC class I molecules to CTLs. We generated ERAP1-deficient mice and analyzed cytotoxic responses upon infection with three viruses, including lymphocytic choriomeningitis virus, which causes vigorous
Firat, Elke, Saveanu, Loredana, Aichele, Peter, Stäheli, Peter, Huai, Jisen, Gaedicke, Simone, Nil, Ahmed, Besin, Gilles, Kanzler, Benoit, Endert, Peter M. van, Niedermann, Gabriele   +10 more
openaire   +4 more sources

Prognostic Impact of ERAP1 Genetic Variants and Haplotypes in Cervical Cancer: Insights From TCGA-CESC and a Brazilian Patient Cohort. [PDF]

Mol Genet Genomic Med
Overview of the study design and main findings on the prognostic impact of ERAP1 genetic variants, haplotypes, and expression in cervical cancer. Genetic and clinical data from TCGA‐CESC and a Brazilian patient cohort were analyzed to evaluate associations with survival outcomes.
Dian AL, Cunha APA, Melo CPS, Nascimento MDDSB, Carvalho MGR, Ruiz JC.   +5 more
europepmc   +2 more sources

Spectral, Anti-Inflammatory, Anti-Pyretic, Leishmanicidal, and Molecular Docking Studies, Against Selected Protein Targets, of a New Bisbenzylisoquinoline Alkaloid

Frontiers in Chemistry, 2021
A new bisbenzylisoquinoline named as chondrofolinol (1) and four reported compounds (2–5) were isolated and characterized from the roots of Berberis glaucocarpa Stapf.
Muhammad Alamzeb, William N. Setzer, Saqib Ali, Behramand Khan, Mamoon-Ur- Rashid, Ihsanullah, Syed Muhammad Salman, Adnan, Muhammad Omer, Javed Ali, Asad Ullah   +10 more
doaj   +1 more source

A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1

SLAS Discovery, 2023
MALDI-TOF MS is a powerful analytical technique that provides a fast and label-free readout for in vitro assays in the high-throughput screening (HTS) environment.
Leonie Müller, Amy K Burton, Chloe L Tayler, James E Rowedder, Jonathan P Hutchinson, Simon Peace, Julie M Quayle, Melanie V Leveridge, Roland S Annan, Matthias Trost, Rachel E Peltier-Heap, Maria Emilia Dueñas   +11 more
doaj   +1 more source

Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma. [PDF]

J Biol Chem, 2011
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme with an important role in processing antigenic peptides presented to class I major histocompatibility complex in the endoplasmic reticulum. In this study, we found that endoplasmic reticulum-retained ERAP1 was secreted from macrophages in response to activation by treatment with
Goto Y, Ogawa K, Hattori A, Tsujimoto M.
europepmc   +4 more sources

Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1

The Journal of Biochemistry, 2018
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multi-functional enzyme. In this study, we analysed its role in lipopolysaccharide-induced inflammatory response in wild-type and ERAP1-knockout mice. Following lipopolysaccharide injection, ERAP1 was secreted into the blood, increasing leucine aminopeptidase activity and NO synthesis therein.
Yoshikuni, Goto, Takahiro J, Nakamura, Kenji, Ogawa, Akira, Hattori, Masafumi, Tsujimoto   +4 more
openaire   +2 more sources

The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I

Scientific Reports, 2021
Processing of N-terminally elongated antigenic peptide precursors by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key step in antigen presentation and the adaptive immune response.
George Mavridis, Anastasia Mpakali, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou, Eleni Kaloumenou, Angeliki Ziotopoulou, Dimitris Georgiadis, Athanasios Papakyriakou, Efstratios Stratikos   +9 more
doaj   +1 more source