Results 51 to 60 of about 5,215 (208)

Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response. [PDF]

, 2013
BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue.
Ford, Byron D, Ford, Gregory D, Gates, Alicia S, Laplaca, Michelle C, Surles-Zeigler, Monique C, White, Todd E   +5 more
core   +2 more sources

A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]

, 2019
Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia, BASILI, IRENE, Botta, Bruno, Bufalieri, Francesca, Caimano, Miriam, Di Marcotullio, Lucia, Ghirga, Francesca, Infante, Paola, LORICCHIO, ELENA, LOSPINOSO SEVERINI, LUDOVICA, Maroder, Marella, Moretti, Marta, Mori, Mattia, Quaglio, Deborah, ROMEO, ISABELLA   +14 more
core   +1 more source

A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

PLoS ONE, 2012
The ERAP1 gene encodes an aminopeptidase involved in antigen processing. A functional polymorphism in the gene (rs30187, Arg528Lys) associates with susceptibility to ankylosying spondylitis (AS), whereas a SNP in the interacting ERAP2 gene increases susceptibility to another inflammatory autoimmune disorder, Crohn's disease (CD). We analysed rs30187 in
F. R. Guerini, R. Cagliani, D. Forni, C. Agliardi, D. Caputo, A. Cassinotti, D. Galimberti, C. Fenoglio, M. Biasin, R. Asselta, E. Scarpini, G.P. Comi, N. Bresolin, M.S. Clerici, M. Sironi   +14 more
openaire   +6 more sources

Association of ERAP1 and IL23R gene polymorphisms with ankylosing spondylitis

Современная ревматология, 2020
Currently, the causes of extra-axial and extra-skeletal manifestations of ankylosing spondylitis (AS) and the possible impact of genetic aspects on its course and clinical features remain unresolved.Objective: to investigate the association of the ...
U. A. Yakubova, O. V. Bugrova, K. A. Nagornova   +2 more
doaj   +1 more source

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia

Frontiers in Immunology, 2020
Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta.
Kimberly Seamon, Lesia O. Kurlak, Michelle Warthan, Efstratios Stratikos, Jerome F. Strauss, Hiten D. Mistry, Eun D. Lee, Eun D. Lee   +7 more
doaj   +1 more source

Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization [PDF]

, 2012
Introduction: In recent genome-wide association studies for psoriatic arthritis (PsA) and psoriasis vulgaris, common coding variants in the TRAF3IP2 gene were identified to contribute to susceptibility to both disease entities.
Apel, Maria, Behrens, Frank, Burkhardt, Harald, Böhm, Beate B., Hüffmeier, Ulrike, Reis, André, Uebe, Steffen   +6 more
core   +2 more sources

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

PLoS ONE, 2008
BackgroundEndoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I molecules.
Irini Evnouchidou, Frank Momburg, Athanasios Papakyriakou, Angeliki Chroni, Leondios Leondiadis, Shih-Chung Chang, Alfred L Goldberg, Efstratios Stratikos   +7 more
doaj   +1 more source

ERAP, KIR, and HLA-C Profile in Recurrent Implantation Failure

Frontiers in Immunology, 2021
The mother’s uterine immune system is dominated by uterine natural killer (NK) cells during the first trimester of pregnancy. These cells express killer cell immunoglobulin-like receptors (KIRs) of inhibitory or activating function. Invading extravillous
Karolina Piekarska, Paweł Radwan, Agnieszka Tarnowska, Andrzej Wiśniewski, Michał Radwan, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Andrzej Malinowski, Izabela Nowak   +9 more
doaj   +1 more source

Autoimmune and autoinflammatory mechanisms in uveitis [PDF]

, 2014
The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult ...
A Amadi-Obi, A Arida, A Cortes, A Fox, A Jager, A Peters, A Rothova, AC Anderson, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AG Commodaro, AG Commodaro, AJ St. Leger, AK Denniston, AK Denniston, AL Oberg, Andrew D. Dick, B Bodaghi, B Engelhardt, BJ Raveney, BJ Raveney, BJ Raveney, BS Sheridan, C Broderick, C Terrada, C-C Chan, CC Murphy, CEI Janssen, Chi-Chao Chan, CJ Calder, CJ Chu, CJ Chu, D Atan, D Atan, D Atan, D Atan, D Banerjee, D Luger, D Perra, DA Carter, DA Copland, DA Copland, DA Copland, DA Copland, DA Jabs, DC Wraith, DF Martin, DJ Hankey, DJ Kilmartin, DL Turner, E Furusato, EB Gouveia, EC Kerr, EC Kerr, ED Mandelcorn, EF Foxman, EF Remmers, EJ Wherry, F An, F Chen, G Geri, GJ Wright, GJ Wright, GR Wallace, H Keino, H Mielants, H. Nida Sen, HL Rosenzweig, HL Rosenzweig, HL Rosenzweig, HM Cherwinski, HN Sen, IJ Crane, J Bauer, J Candia, J Chen, J Correale, JA Todd, JB Fordham, JC Wei, JF Bach, JJ Kuiper, JP Sherlock, JT Rosenbaum, JV Forrester, JV Forrester, JV Forrester, JV Forrester, K Gocho, KG Anderson, KH Sonoda, KM Murphy, KM Murphy, L Jostins, L Mao, Lai Wei, Lindsay B. Nicholson, LK Grange, LK Mackay, LM Wakim, LM Wakim, LP Schewitz, LV Rizzo, M Chen, M Cordero-Coma, M Deckert, M Greter, M Khairallah, M Pepper, MC Jenmalm, MG Netea, MJ Mattapallil, MJ Robertson, MS Suttorp-Schulten, N Hashida, N Mizuki, N Taylor, N Yosef, NA Rao, O Tomkins-Netzer, P Kivisäkk, P Yang, P Zamiri, PA Kurz, PB Medawar, PP Sfikakis, R Banchereau, R Gold, R Plumlee Courtney, R Ramesh, R Shechter, R Zhang, R Zhou, RB Nussenblatt, RB Nussenblatt, RB Nussenblatt, RB Nussenblatt, RB Nussenblatt, Richard W. Lee, RJ Snelgrove, RK Agarwal, RM Hoek, Robert B. Nussenblatt, RP Nair, RR Caspi, RR Caspi, RR Caspi, RR Caspi, RW Darrell, RW Lee, RW Lee, RW Lee, RW Read, RW Read, S Horie, S Hou, S Hou, S Jawad, S Ohno, S Ooka, S Preston, S Sugita, S Sugita, S Sugita, S Sugita, S Yeh, S Zhang, SA Ramsey, SB Su, SC Bendall, SC Teoh, SJ Morrison, SL Masters, SM Islam, SM Sharma, SM Whitcup, SR Boyd, SR Taylor, SR Thurau, SR Thurau, SW McPherson, T Lambe, T Yoshimura, TA Manolio, TM Martin, U Kaufmann, VL Calder, W Chi, W Chi, WF Hickey, WW Soon, Y Fei, Y Kirino, Y Okunuki, Y Peng, Y Usui, YH Lee, Z Li, Z Tu   +203 more
core   +1 more source

TAPBPR: a new player in the MHC class I presentation pathway. [PDF]

, 2015
In order to provide specificity for T cell responses against pathogens and tumours, major histocompatibility complex (MHC) class I molecules present high-affinity peptides at the cell surface to T cells.
Abe, Apcher, Apcher, Bakke, Basha, Bevan, Boyle, Boyle, Brewerton, Brocke, Burton, Chen, Chen, Cho, D'Alessio, Dalchau, Degen, Del Val, Denzin, Denzin, Deverson, Dick, Dong, Du Pasquier, Eisenlohr, Ellgaard, Elliott, Evans, Evnouchidou, Frickel, Gao, Garbi, Garstka, Garstka, Goulder, Grandea, Grandea, Greenwood, Hall, Ham, Hateren, Hermann, Howarth, Joffre, Kanaseki, Kienast, Kleijmeer, Korfali, Kozik, Kunte, Ladasky, Lampen, Landis, Leach, Lehner, Lewis, Lotteau, Marguet, Maric, Neisig, Oliveira, Ortmann, Paquet, Park, Park, Park, Paulsson, Peaper, Peaper, Peh, Petersen, Porter, Purcell, Reeves, Riberdy, Rizvi, Roche, Roche, Romagnoli, Rufer, Sadasivan, Salter, Saric, Saunders, Schlosstein, Serwold, Spies, Spies, Spies, Spiliotis, Starck, Sugita, Suh, Teng, Trowsdale, Turnquist, Turnquist, Vigna, Wearsch, Wearsch, Wei, Williams, Yewdell, York, Zernich, Zhang, Zhang   +106 more
core   +2 more sources