Results 71 to 80 of about 3,465 (162)

DataSheet_1_Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation.pdf

, 2022
Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Efstratios Stratikos (340662), Athanasios Papakyriakou (375921), Anastasia Mpakali (3127524)   +2 more
core   +1 more source

DataSheet_2_Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation.zip

, 2022
Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Efstratios Stratikos (340662), Athanasios Papakyriakou (375921), Anastasia Mpakali (3127524)   +2 more
core   +1 more source

Association between single nucleotide polymorphisms in prospective genes and susceptibility to ankylosing spondylitis and inflammatory bowel disease in a single centre in Turkey

The Turkish Journal of Gastroenterology, 2016
Background/Aims: To establish the prevalence of the single nucleotide polymorphisms (SNPs) of endoplasmic reticulum aminopeptidase 1 (ERAP1), IL-23 receptor (IL-23R), signal transducer and activator of transcription 3 (STAT-3) and Janus kinase 2 (JAK-2 ...
Orhan Küçükşahin, Aşkın Ateş, Nuran Türkçapar, Murat Törüner, Murat Turgay, Türker Duman, Ali Şahin, Mustafa Turgut Yıldızgören, Alexis K. Okoh, Emre Külahçıoğlu, Şükran Erten, Gülay Kınıklı, Saeid Assadpour, Nurşen Düzgün   +13 more
doaj   +1 more source

Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese

Frontiers in Genetics, 2020
Single nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase (ERAP1 and ERAP2) genes are associated with the pathogenesis of bacterial and viral infections.
Shuqiong Zhang, Shuyuan Liu, Nannan Liu, Chuanyin Li, Chuanyin Li, Hui Wang, Lei Shi, Xinwen Zhang, Xinwen Zhang, Ling Bao, Yufeng Yao, Yufeng Yao, Li Shi   +12 more
doaj   +1 more source

ERAP1 and ankylosing spondylitis.

, 2016
The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), which is restricted to HLA-B27 positive cases, has profound pathogenetic implications.

core   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

The Behçet’s disease risk variant HLA-B51/ ERAP1-Hap10 alters human CD8 T cell immunity

, 2022
OBJECTIVES: The ERAP1 haplotype Hap10 encodes for a variant allotype of the ER-resident peptide-trimming aminopeptidase ERAP1 with low enzymatic activity. This haplotype recessively confers the highest risk for Behçet’s diseases (BD) currently known, but
Arshed Fahad Al-Obeidi, Hatemi, Gulen, Kugler, Matthias C., Ueberheide, Beatrix M., Matthias Christian Kugler, Gulen Hatemi, Johannes Nowatzky, Al-Obeidi, Arshed F., Beatrix M Ueberheide, Yesim Ozguler, Kugler, Matthias Christian, Al-Obeidi, Arshed Fahad, Cavers, Ann, Nowatzky, Johannes, Ozguler, Yesim, Ann Cavers, Manches, Olivier, Didar Ucar, Olivier Manches, Ucar, Didar   +19 more
core   +1 more source

Integrative Multiomics and Single‐Cell Analyses Identify FKBP10 as a Predictor of Radiotherapy Outcome in Colorectal Cancer

Human Mutation, Volume 2026, Issue 1, 2026.
Background Radiotherapy resistance limits colorectal cancer (CRC) treatment efficacy, with only 15%–20% of patients achieving a complete response. Validated biomarkers predicting treatment response and serving as therapeutic targets are critically needed.
Fu Xinmo, Bai Minghua, Qiu Xu, Li Weiwei, Wang Lin, Dai Qinghui, Wang Rui, Zhu Ji, Hao Chi   +8 more
wiley   +1 more source

In vitro characterisation of ERAP1 mechanism and antigen processing

, 2018
The aminopeptidase ERAP1 is crucial for processing peptides for presentation by MHC class I, starting from sub-optimal N-terminally extended peptides.
Beton, Mary E.
core   +1 more source

Association Study of Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 and 2 Genes in Iranian Women with Preeclampsia

Iranian Journal of Public Health, 2019
Background: Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) are involved in blood pressure regulation and single nucleotide polymorphisms (SNPs) of these genes have been linked to preeclampsia. This study intended to assess the association of
Hamid DARGAHI, Mohammad Hossein NICKNAM, Mahroo MIRAHMADIAN, Mahdi MAHMOUDI, Saeed ASLANI, Maryam SADROSADAT, Robabeh GHODSSI-GHASSEMABADI, Ali Akbar AMIRZARGAR   +7 more
doaj   +1 more source