Results 71 to 80 of about 3,350 (175)

Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis

, 2014
For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown.
Reeves, Emma, Edwards, Christopher J., Elliott, Tim, James, Edward, Colebatch-Bourn, Alexandra   +4 more
core   +1 more source

Integrative Multiomics and Single‐Cell Analyses Identify FKBP10 as a Predictor of Radiotherapy Outcome in Colorectal Cancer

Human Mutation, Volume 2026, Issue 1, 2026.
Background Radiotherapy resistance limits colorectal cancer (CRC) treatment efficacy, with only 15%–20% of patients achieving a complete response. Validated biomarkers predicting treatment response and serving as therapeutic targets are critically needed.
Fu Xinmo, Bai Minghua, Qiu Xu, Li Weiwei, Wang Lin, Dai Qinghui, Wang Rui, Zhu Ji, Hao Chi   +8 more
wiley   +1 more source

Developing long read sequencing and its application and understanding the role of ERAP1 in cervical carcinoma.

, 2023
Long read sequencing of components of the antigen processing and presentation (APP) pathway, specifically endoplasmic reticulum aminopeptidase 1 (ERAP1), could provide a new tool for identifying those women that are at high risk of poor cervical cancer ...
Christodoulaki, Michaela Eleni
core   +1 more source

Association between single nucleotide polymorphisms in prospective genes and susceptibility to ankylosing spondylitis and inflammatory bowel disease in a single centre in Turkey

The Turkish Journal of Gastroenterology, 2016
Background/Aims: To establish the prevalence of the single nucleotide polymorphisms (SNPs) of endoplasmic reticulum aminopeptidase 1 (ERAP1), IL-23 receptor (IL-23R), signal transducer and activator of transcription 3 (STAT-3) and Janus kinase 2 (JAK-2 ...
Orhan Küçükşahin, Aşkın Ateş, Nuran Türkçapar, Murat Törüner, Murat Turgay, Türker Duman, Ali Şahin, Mustafa Turgut Yıldızgören, Alexis K. Okoh, Emre Külahçıoğlu, Şükran Erten, Gülay Kınıklı, Saeid Assadpour, Nurşen Düzgün   +13 more
doaj   +1 more source

Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese

Frontiers in Genetics, 2020
Single nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase (ERAP1 and ERAP2) genes are associated with the pathogenesis of bacterial and viral infections.
Shuqiong Zhang, Shuyuan Liu, Nannan Liu, Chuanyin Li, Chuanyin Li, Hui Wang, Lei Shi, Xinwen Zhang, Xinwen Zhang, Ling Bao, Yufeng Yao, Yufeng Yao, Li Shi   +12 more
doaj   +1 more source

Lnc‐CHRM4‐2:1 Inhibits M2 Polarization and Efferocytosis of Macrophages by Downregulating MerTK and SLC2A1 in Rheumatoid Arthritis

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Objective Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. Long noncoding RNAs (lncRNAs) have been documented to play important roles in the pathogenesis of RA. This study is aimed to investigate the differentially expressed lncRNAs in RA and explore the underlying roles and mechanisms of RA‐specific lncRNAs.
Jinjin Chu, Jie Zang, Lili Zhang, Zhuojian Qu, Haibo Li, Chunjuan Yang, Jiamei Sun, Linlin Gai, Xuecheng Sun, Donghua Xu, Poorani Gurumallesh   +10 more
wiley   +1 more source

METTL3/m6A‐Dependent SERPINE1/VEGFA Axis Mediates Sublethal Heat‐Induced Angiogenesis in Hepatocellular Carcinoma

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Heat ablation techniques, such as microwave and radiofrequency ablation, are established interventions for hepatocellular carcinoma (HCC). However, incomplete ablation often leads to angiogenesis‐driven metastasis and recurrence, undermining long‐term treatment efficacy.
Zhuoyang Fan, Yang Gao, Juncheng Wan, Yiwei Zhu, Ming Li, Xiaochen Chen, Guowei Yang, Yao Luo   +7 more
wiley   +1 more source

Association of ERAP1 Allelic Variants with Risk of Ankylosing Spondylitis

Acta Naturae, 2010
Ankylosing spondylitis (AS) belongs to a group of autoimmune diseases affecting the axial skeleton. Beside thehla-b*27allele, several other human genes that control the variety processes of immune homeostasis are considered to be associated with AS manifestation in different human populations.
Zvyagin, I., Dorodnykh, V., Mamedov, I., Staroverov, D., Bochkova, A., Rebrikov, D., Lebedev, Y.   +6 more
openaire   +3 more sources

Allele frequencies of 11 ERAP1 SNPs.

, 2020
Allele frequencies of 11 ERAP1 SNPs.
Parisa Riahi (8407764), Ali Javinani (5922311), Shayan Mostafaei (5478275), Akira Meguro (157086), Farhad Shahram (5478272), Amir Ashraf-Ganjouei (5500931), Anoshirvan Kazemnejad (6679151), Mahdi Mahmoudi (836542), Nobuhisa Mizuki (46911), Seyedeh Tahereh Faezi (8407767)   +9 more
core   +1 more source

The Relationship Between Inhibition, Conformation, and Catalysis of the Aminopeptidase ERAP1

, 2018
ERAP1 is an aminopeptidase that is a component of antigen processing. To distinguish the role of ERAP1 from homologs ERAP2 and IRAP, I identified three specific ERAP1 inhibitors via a high-throughput screen.
Maben, Zachary
core   +1 more source