Results 91 to 100 of about 3,350 (175)

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis. [PDF]

, 2015
Objective Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly associated with ankylosing spondylitis (AS).
Bowness, Paul, Bunting, Helen, Chan, Antoni, Ridley, Anna, Ridley, Anna L., Georgiadis, Dimitris, Al-Mossawi, Mohammad H., Hammitzsch, A, Al-Mossawi, Mohammad Hussein, Georgiadis, D, Kollnberger, S, Bowness, P, Chen, Liye, Hammitzsch, Ariane, Chen, L, Kollnberger, Simon, Ridley, AL, Chan, A, Al-Mossawi, MH, Bunting, H   +19 more
core   +1 more source

Functionally distinct ERAP1 haplotype combinations define individuals with Ankylosing Spondylitis (P5047)

, 2013
Ankylosing Spondylitis (AS) is a chronic inflammatory disease which commonly affects the spine occurring in approximately 0.5% of adults of European descent.
Edwards, C.J., Reeves, E., James, E., Elliott, T., Colebatch, A.N.   +4 more
core   +1 more source

Exploring the Involvement of ERAP1 in the Pathogenesis of Non-Infectious Uveitis: A Systematic Review

Life
Background: Non-infectious uveitis (NIU) is an inflammatory ocular condition often associated with systemic immune-mediated disorders. The pathogenesis of NIU is complex and involves genes from the Human Leukocyte Antigen (HLA) class I system ...
Ioana-Maria Rizea, Horia Tudor Stanca, Vasile Potop, Dana-Margareta-Cornelia Dăscălescu, Silvia Ioana Andrei, Ioana Teodora Tofolean, Alina Popa-Cherecheanu, Mihnea Munteanu, Marius Cherciu, Olivia-Mihaela Popa   +9 more
doaj   +1 more source

Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity

, 2013
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims peptides for MHC class I presentation, influencing the degree and specificity of CD8+ T cell responses.
Edwards, C.J., Reeves, E., James, E., Elliott, T.   +3 more
core   +1 more source

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

Frontiers in Immunology, 2018
Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A*29:02), ankylosing spondylitis (HLA-B*27), Behçet's disease (HLA-B*51), and psoriasis (HLA-C*06:02). The
José A. López de Castro
doaj   +1 more source

Variant in ERAP1 promoter region is associated with low expression in a patient with a Behçet-like MHC-I-opathy

, 2020
Behçet disease (BD) is an immune-mediated disease. The cause of BD remains unknown, but the existence of multiple pathological pathways is suspected, including different genetic factors.
Marvig, Rasmus L., Chrysoula Dimopoulou, Nielsen, Finn C., Sundal, Jon, Dimopoulou, Chrysoula, Jon Sundal, Finn C. Nielsen, Pål Aukrust, Lundgren, Jens D., Aukrust, Pål, Jens D. Lundgren, Ullum, Henrik, Rasmus L. Marvig, Henrik Ullum   +13 more
core   +1 more source

In vitro characterisation of ERAP1 mechanism and antigen processing

, 2018
The aminopeptidase ERAP1 is crucial for processing peptides for presentation by MHC class I, starting from sub-optimal N-terminally extended peptides.
Beton, Mary E.
core   +1 more source

Effect of ERAP1 modulation on induction of protective anti-tumour immunity

ERAP1 trimming of antigenic peptides has an important role in anti-cancer immune responses, by generating optimal peptides for MHC-I loading and presentation to CD8+ T cells.
Guglietta, Dario Vinicio
core   +1 more source

Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran

Iranian Journal of Allergy, Asthma and Immunology, 2012
Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for  AS susceptibility after HLA-B27.
Mahdi Mahmoudi, Ahmad Reza Jamshidi, Ali Akbar Amirzargar, Elham Farhadi, Keramat Nourijelyani, Sasan Fallahi, Mona Oraei, Sahar Noori, Mohammad Hossein Nicknam   +8 more
doaj  

A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis

Chinese Medical Journal
. Background:. Findings on the association of genetic factors and colorectal cancer (CRC) survival are limited and inconsistent, and revealing the mechanism underlying their prognostic roles is of great importance.
Danyi Zou, Yimin Cai, Meng Jin, Ming Zhang, Yizhuo Liu, Shuoni Chen, Shuhui Yang, Heng Zhang, Xu Zhu, Chaoqun Huang, Ying Zhu, Xiaoping Miao, Yongchang Wei, Xiaojun Yang, Jianbo Tian, Jing Ni, Xuehong Zhang   +16 more
doaj   +1 more source