Results 91 to 100 of about 5,215 (208)

Decoding MHC loss: Molecular mechanisms and implications for immune resistance in cancer

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Tumour cells evade immune surveillance by downregulating MHC expression through transcriptional repression, lysosomal degradation and post‐translational modifications. Pharmacological agents interventing epigenetic and metabolic can upregulate MHC expression and improve T cell activation.
Pei Lin, Yunfan Lin, Xu Chen, Xinyuan Zhao, Li Cui   +4 more
wiley   +1 more source

Apprêtement des antigènes présentés par les molécules de classe I du CMH [PDF]

, 2006
Les défenses immunitaires de l’organisme vis-à-vis des agents pathogènes et des cellules malignes reposent en grande partie sur la surveillance par les lymphocytes T cytotoxiques.
Endert, Peter van
core  

Analysis of Hyperexpanded T Cell Clones in SARS‐CoV‐2 Vaccine‐Associated Liver Injury by Spatial Proteomics and Transcriptomics

Liver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background and Aims SARS‐CoV‐2 vaccine‐associated liver injury (SVALI) is a rare event and its pathophysiology remains unclear. Previous studies have found an oligoclonal CD8+ T cell infiltrate and SARS‐CoV‐2 spike antigen‐specific T cells in the liver of patients with SVALI. Therefore, we aimed to characterise the immune infiltrate in a liver
Sarp Uzun, Asmita Pant, Ewelina Bartoszek, Paul Gueguen, Stefan Frei, Hélène Heusler, Ilaria Arborelli, Carl Philipp Zinner, Neşe Karadağ Soylu, Benedetta Terziroli Beretta‐Piccoli, Cumali Efe, Matthias S. Matter   +11 more
wiley   +1 more source

Metabolomics in psoriatic disease: pilot study reveals metabolite differences in psoriasis and psoriatic arthritis. [PDF]

, 2014
ImportanceWhile "omics" studies have advanced our understanding of inflammatory skin diseases, metabolomics is mostly an unexplored field in dermatology.ObjectiveWe sought to elucidate the pathogenesis of psoriatic diseases by determining the differences
Armstrong, April W, Azizi, Baktazh, Dhillon, Jaskaran, Fiehn, Oliver, Grapov, Dmitry, Johnson, Mary Ann, Wu, Julie   +6 more
core   +2 more sources

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Restoring Tumor Cell Immunogenicity Through Ion‐Assisted p53 mRNA Domestication for Enhanced In Situ Cancer Vaccination Effect

Advanced Science, Volume 12, Issue 14, April 10, 2025.
PRIZE, a P53‐repair nanosystem based on a virus‐mimicking nanostructure, delivers p53 mRNA into tumor cells, restoring P53 levels and enhancing immunogenicity. Its biomineralized structure stabilizes the mRNA, prolongs P53's half‐life, and precisely targets tumors.
Yan Liang, Jingge Zhang, Jinjin Wang, Yuhe Yang, Xinyu Tan, Shuguang Li, Zhenzhen Guo, Zhenzhong Zhang, Junjie Liu, Jinjin Shi, Kaixiang Zhang   +10 more
wiley   +1 more source

ENDOPLASMIC RETICULUM AMINO PEPTIDASE 1 (ERAP1) IN ANKYLOSING SPONDYLITIS

Romanian Journal of Rheumatology, 2015
Recently, endoplasmic reticulum aminopeptidase 1 (ERAP1) gene polymorphisms were associated with ankylosing spondylitis (AS) in genome-wide association studies (GWAS), associations which later were replicated across different populations, including the Romanian population.
Marius Cherciu, Mihai Bojinca, Laura Ioana Cherciu, Constantin Bara, Olivia Mihaela Popa   +4 more
openaire   +1 more source

Association Study of Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 and 2 Genes in Iranian Women with Preeclampsia

Iranian Journal of Public Health, 2019
Background: Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) are involved in blood pressure regulation and single nucleotide polymorphisms (SNPs) of these genes have been linked to preeclampsia. This study intended to assess the association of
Hamid DARGAHI, Mohammad Hossein NICKNAM, Mahroo MIRAHMADIAN, Mahdi MAHMOUDI, Saeed ASLANI, Maryam SADROSADAT, Robabeh GHODSSI-GHASSEMABADI, Ali Akbar AMIRZARGAR   +7 more
doaj   +1 more source

iPSC‐derived human cortical organoids display profound alterations of cellular homeostasis following SARS‐CoV‐2 infection and Spike protein exposure

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Graphical representation of the study workflow. iPSC‐derived human cortical organoids (HCOs) at Day 40, were in vitro infected by SARS‐CoV‐2 or exposed to the Spike protein and viral infection/replication was assessed by a multidisciplinary approach using RT‐qPCR, TCID50, and immunofluorescence.
Gioia Cappelletti, Lorenzo Brambilla, Sergio Strizzi, Fiona Limanaqi, Valentina Melzi, Mafalda Rizzuti, Monica Nizzardo, Irma Saulle, Daria Trabattoni, Stefania Corti, Mario Clerici, Mara Biasin   +11 more
wiley   +1 more source

First fragment-based screening identifies new chemotypes inhibiting ERAP1-metalloprotease

European Journal of Medicinal Chemistry
Inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) by small-molecules is being eagerly investigated for the treatment of various autoimmune diseases and in the field of immuno-oncology after its active involvement in antigen presentation and processing.
Fougiaxis, Vasileios, Barcherini, Valentina, Petrovic, Milena, Sierocki, Pierre, Warenghem, Sandrine, Leroux, Florence, Bou Karroum, Nour, Petit-Cancelier, Fabien, Rodeschini, Vincent, Roche, Didier, Deprez, Benoit, Deprez-Poulain, Rebecca   +11 more
openaire   +4 more sources