Results 91 to 100 of about 3,465 (162)

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis

, 2016
Objective: Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly associated with ankylosing spondylitis (AS).
Ridley, A., Chen, L., Hammitzsch, A., Kollnberger, S., Bunting, H., Georgiadis, D., Bowness, P., Chan, A., Al-Mossawi, M.H.   +8 more
core  

Functionally distinct ERAP1 haplotype combinations define individuals with Ankylosing Spondylitis (P5047)

, 2013
Ankylosing Spondylitis (AS) is a chronic inflammatory disease which commonly affects the spine occurring in approximately 0.5% of adults of European descent.
Edwards, C.J., Reeves, E., James, E., Elliott, T., Colebatch, A.N.   +4 more
core   +1 more source

Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran

Iranian Journal of Allergy, Asthma and Immunology, 2012
Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for  AS susceptibility after HLA-B27.
Mahdi Mahmoudi, Ahmad Reza Jamshidi, Ali Akbar Amirzargar, Elham Farhadi, Keramat Nourijelyani, Sasan Fallahi, Mona Oraei, Sahar Noori, Mohammad Hossein Nicknam   +8 more
doaj  

Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity

, 2013
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims peptides for MHC class I presentation, influencing the degree and specificity of CD8+ T cell responses.
Edwards, C.J., Reeves, E., James, E., Elliott, T.   +3 more
core   +1 more source

A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis

Chinese Medical Journal
. Background:. Findings on the association of genetic factors and colorectal cancer (CRC) survival are limited and inconsistent, and revealing the mechanism underlying their prognostic roles is of great importance.
Danyi Zou, Yimin Cai, Meng Jin, Ming Zhang, Yizhuo Liu, Shuoni Chen, Shuhui Yang, Heng Zhang, Xu Zhu, Chaoqun Huang, Ying Zhu, Xiaoping Miao, Yongchang Wei, Xiaojun Yang, Jianbo Tian, Jing Ni, Xuehong Zhang   +16 more
doaj   +1 more source

Optimization of potent and selective cyclohexyl acid ERAP1 inhibitors using structure- and property-based drug design [PDF]

Endoplasmic reticulum aminopeptidase 1 (ERAP1) cleaves the N-terminal amino acids of peptides, which can then bind onto major histocompatibility class I (MHC-I) molecules for presentation onto the cell surface, driving the activation of adaptive immune ...
Lindsay, David M., Lonsdale, Richard, Tayler, Chloe L., Young, Robert J., Hackett, Andrew S., Schneck, Jessica L., Scott-Stevens, Paul, Walker, Ann L., Convery, Máire A., Rowedder, James E., Lea, Jonatahn D., Hryczanek, Ross P., Nickels, Leng, Temponeras, Ioannis, Kitchen, Semra, Holmes, Duncan S., Hutchinson, Jonathan P., Neu, Margarete, Rowland, Paul, Phillipou, Alex, Wojno-Picon, Justyna, Tinworth, Christopher P., Liddle, John, Chung, Chun-wa, Stratikos, Efstratios, Law, Robert P., Korczynska, Justyna, Sheehan, Hester   +27 more
core   +1 more source

Conditional logistic regression models of HLA-B and of ERAP1 haplotypes.

, 2014
Conditional logistic regression models of HLA-B and of ERAP1 haplotypes.
Marco Antonio Montes-Cano (597639), Rocío González-León (597642), Genaro Graña-Gil (597643), Marta Conde-Jaldón (597638), Javier Martín (2584444), Juan Sánchez-Bursón (597644), Santos Castañeda (118673), Ana Celia Barnosi-Marín (597646), José Raul García-Lozano (597640), Gerard Espinosa (287998), Mónica Rodríguez Carballeira (597649), Patricia Fanlo (597648), Lourdes Ortiz-Fernández (597641), Teresa Camps (597650), María Francisca González-Escribano (597651), Norberto Ortego-Centeno (213984), Roser Solans (597647), Miguel Angel González-Gay (597645)   +17 more
core   +1 more source

ERAP1-KO mice exhibit dramatically enhanced capabilities to respond to rEA and release pro-inflammatory cytokines.

, 2013
C57BL/6 WT and ERAP1-KO mice were either mock (PBS) injected or intraperitoneally injected with 100 ng/mouse of rEA protein. n = 4 for all groups of mice.
Yasser A. Aldhamen (208360), David P. W. Rastall (437032), Charles F. Aylsworth (215650), Yuliya Pepelyayeva (437033), Andrea Amalfitano (208378), Sergey S. Seregin (208367), Christopher J. Busuito (437034), Sungjin Kim (106517), Sarah Godbehere-Roosa (437035)   +8 more
core   +1 more source

Developing long read sequencing and its application and understanding the role of ERAP1 in cervical carcinoma.

, 2023
Long read sequencing of components of the antigen processing and presentation (APP) pathway, specifically endoplasmic reticulum aminopeptidase 1 (ERAP1), could provide a new tool for identifying those women that are at high risk of poor cervical cancer ...
Christodoulaki, Michaela Eleni
core  

Expression and purification of endoplasmic reticulum aminopeptidases and identification of the ER retention signal of ERAP1

, 2010
泛素-26S蛋白解體系統能將蛋白質降解成2-25個胺基酸之胜肽。大部分的胜肽藉由細胞質中的胜肽酶快速將其水解成胺基酸。然而在高等的脊椎動物中，有少部分的胜肽會逃脫此途徑，且被運輸至內質網中，並與第一型主要組織適應性複合體結合而表現在細胞表面。ERAP1 (endoplasmic reticulum aminopeptidase 1) 和ERAP2 (endoplasmic reticulum aminopeptidase 2) 為含有鋅並具有HEXXHX18E motif及GAMEN ...
Feng, Chan-Chih, 馮展誌
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