Results 111 to 120 of about 5,215 (208)
How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins
Frontiers in Immunology, 2018 Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A*29:02), ankylosing spondylitis (HLA-B*27), Behçet's disease (HLA-B*51), and psoriasis (HLA-C*06:02). The
José A. López de Castro
doaj +1 more source
Le mélanome et les polymorphismes associés au dysfonctionnement du système immunitaire [PDF]
, 2012 La recherche biomédicale profite de plus en plus au développement des techniques de séquençage et d'analyse de l'ADN. Les coûts du séquençage ont drastiquement baissés au cours de ces dernières années et les genomes-wides associations studies (GWAS) ont ...
Naso, S.
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Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Caracterização fenotípica e genotípica de doentes com espondilite anquilosante [PDF]
, 2014 Mestrado em Biologia Molecular e CelularA espondilite anquilosante (EA) é uma doença reumática inflamatória crónica (comprometimento do aparelho músculo-esquelético), que afeta o esqueleto axial e, em menor grau, articulações periféricas e órgãos extra ...
Gaspar, Joana Maria Pinheiro
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Iranian Journal of Allergy, Asthma and Immunology, 2012 Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27.
Mahdi Mahmoudi +8 more
doaj
A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis
Chinese Medical Journal. Background:. Findings on the association of genetic factors and colorectal cancer (CRC) survival are limited and inconsistent, and revealing the mechanism underlying their prognostic roles is of great importance.
Danyi Zou +16 more
doaj +1 more source
A Review of Ankylosing Spondylitis [PDF]
, 2017 Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
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, 2018 ERAP1 has been associated with a set of immune-mediated diseases, including ankylosing spondylitis. Currently, there is no selective and potent ERAP1 inhibitor available that would allow in-depth research of its functions and roles in diseases. Therefore, the aim of this work is to apply fragment-based drug design approach for the development of such ...
openaire +1 more source
A comparative Genome-Wide Association Interaction study using BOOST and MB-MDR algorithms on Ankylosing Spondylitis [PDF]
, 2013 Genome-Wide Association (GWA) studies have gained popularity after the completion of the Human Genome Project and advancement of high-throughput technologies. These studies aim to scan thousands of genomic variations (e.g., SNPs) for their association to
Bessonov, Kyrylo
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Sex-dependent effects of ERAP1 deficiency [PDF]
Nature Reviews Nephrology, 2019 openaire +2 more sources