Results 81 to 90 of about 3,350 (175)

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, Volume 12, Issue 36, September 25, 2025.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Association Study of Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 and 2 Genes in Iranian Women with Preeclampsia

Iranian Journal of Public Health, 2019
Background: Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) are involved in blood pressure regulation and single nucleotide polymorphisms (SNPs) of these genes have been linked to preeclampsia. This study intended to assess the association of
Hamid DARGAHI, Mohammad Hossein NICKNAM, Mahroo MIRAHMADIAN, Mahdi MAHMOUDI, Saeed ASLANI, Maryam SADROSADAT, Robabeh GHODSSI-GHASSEMABADI, Ali Akbar AMIRZARGAR   +7 more
doaj   +1 more source

Epistatic interaction of ERAP1 and HLA-B in Behçet disease: a replication study in the Spanish population.

PLoS ONE, 2014
Behçet's disease (BD) is a multifactorial disorder associated with the HLA region. Recently, the ERAP1 gene has been proposed as a susceptibility locus with a recessive model and with epistatic interaction with HLA-B51.
Marta Conde-Jaldón, Marco Antonio Montes-Cano, José Raul García-Lozano, Lourdes Ortiz-Fernández, Norberto Ortego-Centeno, Rocío González-León, Gerard Espinosa, Genaro Graña-Gil, Juan Sánchez-Bursón, Miguel Angel González-Gay, Ana Celia Barnosi-Marín, Roser Solans, Patricia Fanlo, Mónica Rodríguez Carballeira, Teresa Camps, Santos Castañeda, Javier Martín, María Francisca González-Escribano   +17 more
doaj   +1 more source

ERAP1 polymorphisms interactions and their association with Behçet's disease susceptibly: Application of Model-Based Multifactor Dimension Reduction Algorithm (MB-MDR).

PLoS ONE, 2020
BACKGROUND:Behçet's disease (BD) is a chronic multi-systemic vasculitis with a considerable prevalence in Asian countries. There are many genes associated with a higher risk of developing BD, one of which is endoplasmic reticulum aminopeptidase-1 (ERAP1).
Parisa Riahi, Anoshirvan Kazemnejad, Shayan Mostafaei, Akira Meguro, Nobuhisa Mizuki, Amir Ashraf-Ganjouei, Ali Javinani, Seyedeh Tahereh Faezi, Farhad Shahram, Mahdi Mahmoudi   +9 more
doaj   +1 more source

Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism

, 2022
The endoplasmic-reticulum aminopeptidase ERAP1 processes antigenic peptides for loading on MHC-I proteins and recognition by CD8 T cells as they survey the body for infection and malignancy. Crystal structures have revealed ERAP1 in either open or closed
Stratikos, Efstratios, Stern, Lawrence J., Georgiadis, Dimitris, Maben, Zachary, Arya, Richa   +4 more
core   +1 more source

Association between IL23R and ERAP1 polymorphisms and sacroiliac or spinal MRI inflammation in spondyloarthritis: DESIR cohort data

Arthritis Research & Therapy, 2019
Background To investigate the association between 12 single nucleotide polymorphisms (SNPs) located on ERAP1 and IL23R with the presence of inflammation on the sacroiliac joint (SIJ) or spinal magnetic resonance imagery (MRI) in an early onset ...
Adeline Ruyssen-Witrand, Cécile Luxembourger, Alain Cantagrel, Delphine Nigon, Pascal Claudepierre, Yannick Degboe, Arnaud Constantin   +6 more
doaj   +1 more source

ERAP1 Gene Variants and Haplotypes Associated With Psoriasis Vulgaris of Han Chinese in Inner Mongolia

Molecular Genetics & Genomic Medicine
Background This study aimed to investigate the association between genetic variants of ERAP1 (OMIM: 606832) and psoriasis vulgaris (PsV) susceptibility in Inner Mongolia Han nationality.
Xin Li, Jia Bao, Liya Ai, Fan‐Rui Yang, Bo Yu, Yan‐Ping Huang, Na Li, Wen‐Yuan Ding, Zhi‐Qiang Sun, Xin‐Xiang Lv, Jian‐Wen Han   +10 more
doaj   +1 more source

Association of ERAP1 Gene Polymorphisms With Behcet's Disease in Han Chinese

, 2015
PURPOSE. Behcet's disease (BD) is a common uveitis entity in China. The endoplasmic reticulum aminopeptidase 1 (ERAP1), has a significant influence on the stability and immunological properties of MHC-I loaded peptides.
Yang, Peizeng, Yu, Hongsong, Li, Hua, Zheng, Minming, Liu, Yunjia, Zhang, Lijun, Kijlstra, Aize   +6 more
core   +1 more source

Prevalence of genetic risk factors of psoriasis among the population of the Russian Federation

Vestnik Dermatologii i Venerologii, 2017
Goal. To assess the prevalence of polymorphisms of genes of the predisposition to psoriasis among the population of the Russian Federation. Materials and methods. The authors examined 546 psoriasis patients and 206 healthy people. The polymorphism of the
A. A. Kubanov, A. A. Kubanova, A. E. Karamova, A. A. Mineyeva   +3 more
doaj   +1 more source