Results 81 to 90 of about 3,465 (162)

Epistatic interaction of ERAP1 and HLA-B in Behçet disease: a replication study in the Spanish population.

PLoS ONE, 2014
Behçet's disease (BD) is a multifactorial disorder associated with the HLA region. Recently, the ERAP1 gene has been proposed as a susceptibility locus with a recessive model and with epistatic interaction with HLA-B51.
Marta Conde-Jaldón, Marco Antonio Montes-Cano, José Raul García-Lozano, Lourdes Ortiz-Fernández, Norberto Ortego-Centeno, Rocío González-León, Gerard Espinosa, Genaro Graña-Gil, Juan Sánchez-Bursón, Miguel Angel González-Gay, Ana Celia Barnosi-Marín, Roser Solans, Patricia Fanlo, Mónica Rodríguez Carballeira, Teresa Camps, Santos Castañeda, Javier Martín, María Francisca González-Escribano   +17 more
doaj   +1 more source

ERAP1 polymorphisms interactions and their association with Behçet's disease susceptibly: Application of Model-Based Multifactor Dimension Reduction Algorithm (MB-MDR).

PLoS ONE, 2020
BACKGROUND:Behçet's disease (BD) is a chronic multi-systemic vasculitis with a considerable prevalence in Asian countries. There are many genes associated with a higher risk of developing BD, one of which is endoplasmic reticulum aminopeptidase-1 (ERAP1).
Parisa Riahi, Anoshirvan Kazemnejad, Shayan Mostafaei, Akira Meguro, Nobuhisa Mizuki, Amir Ashraf-Ganjouei, Ali Javinani, Seyedeh Tahereh Faezi, Farhad Shahram, Mahdi Mahmoudi   +9 more
doaj   +1 more source

Association between IL23R and ERAP1 polymorphisms and sacroiliac or spinal MRI inflammation in spondyloarthritis: DESIR cohort data

Arthritis Research & Therapy, 2019
Background To investigate the association between 12 single nucleotide polymorphisms (SNPs) located on ERAP1 and IL23R with the presence of inflammation on the sacroiliac joint (SIJ) or spinal magnetic resonance imagery (MRI) in an early onset ...
Adeline Ruyssen-Witrand, Cécile Luxembourger, Alain Cantagrel, Delphine Nigon, Pascal Claudepierre, Yannick Degboe, Arnaud Constantin   +6 more
doaj   +1 more source

ERAP1 Gene Variants and Haplotypes Associated With Psoriasis Vulgaris of Han Chinese in Inner Mongolia

Molecular Genetics & Genomic Medicine
Background This study aimed to investigate the association between genetic variants of ERAP1 (OMIM: 606832) and psoriasis vulgaris (PsV) susceptibility in Inner Mongolia Han nationality.
Xin Li, Jia Bao, Liya Ai, Fan‐Rui Yang, Bo Yu, Yan‐Ping Huang, Na Li, Wen‐Yuan Ding, Zhi‐Qiang Sun, Xin‐Xiang Lv, Jian‐Wen Han   +10 more
doaj   +1 more source

The role of polymorphic ERAP1 in autoinflammatory disease

, 2018
Autoimmune and autoinflammatory conditions represent a group of disorders characterized by self-directed tissue damage due to aberrant changes in innate and adaptive immune responses.
Reeves, Emma, James, Edward, Emma Reeves, Edward James   +3 more
core   +1 more source

Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population

Frontiers in Immunology
IntroductionRheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II, nevertheless some HLA class I associations have also been observed.
Iryna Kril, Iryna Kril, Andrzej Wiśniewski, Agnieszka Tarnowska, Khrystyna Lishchuk-Yakymovych, Yaryna Bojko, Piotr Kuśnierczyk, Valentyna V. Chopyak, Izabela Nowak   +8 more
doaj   +1 more source

Prevalence of genetic risk factors of psoriasis among the population of the Russian Federation

Vestnik Dermatologii i Venerologii, 2017
Goal. To assess the prevalence of polymorphisms of genes of the predisposition to psoriasis among the population of the Russian Federation. Materials and methods. The authors examined 546 psoriasis patients and 206 healthy people. The polymorphism of the
A. A. Kubanov, A. A. Kubanova, A. E. Karamova, A. A. Mineyeva   +3 more
doaj   +1 more source

N-terminal specificity of decapeptide trimming by ERAP1.

, 2013
All peptides are based on the same template varying in their N-terminus (indicated as X in the sequence below the graph). 100 µM of each peptide was incubated with 40 ng of ERAP1 at 37°C and the reaction products analyzed as in figure 1. A representative
Efstratios Stratikos (340662), Shih-Chung Chang (172580), Irini Evnouchidou (375919), Angeliki Chroni (340655), Athanasios Papakyriakou (375921), Frank Momburg (208205), Leondios Leondiadis (375922), Alfred L. Goldberg (82735)   +7 more
core   +1 more source

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

Frontiers in Immunology, 2018
Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A*29:02), ankylosing spondylitis (HLA-B*27), Behçet's disease (HLA-B*51), and psoriasis (HLA-C*06:02). The
José A. López de Castro
doaj   +1 more source

The Role of Aminopeptidase ERAP1 in Human Pathology—A Review

Current Issues in Molecular Biology
Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic
Laura Țiburcă, Dana Carmen Zaha, Maria Claudia Jurca, Emilia Severin, Aurora Jurca, Alexandru Daniel Jurca   +5 more
doaj   +1 more source