Results 61 to 70 of about 3,350 (175)

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, Volume 183, Issue 12, Page 3355-3376, June 2026.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism

OncoImmunology, 2017
Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components.
Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K. Grabowska, Angelika B. Riemer   +9 more
doaj   +1 more source

Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Glucose metabolic reprogramming is a central driver of immunosuppression in the tumour microenvironment, orchestrating immune dysfunction through multiple interconnected mechanisms. Glucose competition establishes a selective bioenergetic hierarchy that constrains antitumour immunity, whereas lactate accumulation and its reciprocal crosstalk with ...
Yang Wang, Yijun Lu, Jian Zhou, Xinrong Yang   +3 more
wiley   +1 more source

The Behçet’s disease risk variant HLA-B51/ ERAP1-Hap10 alters human CD8 T cell immunity

, 2022
OBJECTIVES: The ERAP1 haplotype Hap10 encodes for a variant allotype of the ER-resident peptide-trimming aminopeptidase ERAP1 with low enzymatic activity. This haplotype recessively confers the highest risk for Behçet’s diseases (BD) currently known, but
Arshed Fahad Al-Obeidi, Hatemi, Gulen, Kugler, Matthias C., Ueberheide, Beatrix M., Matthias Christian Kugler, Gulen Hatemi, Johannes Nowatzky, Al-Obeidi, Arshed F., Beatrix M Ueberheide, Yesim Ozguler, Kugler, Matthias Christian, Al-Obeidi, Arshed Fahad, Cavers, Ann, Nowatzky, Johannes, Ozguler, Yesim, Ann Cavers, Manches, Olivier, Didar Ucar, Olivier Manches, Ucar, Didar   +19 more
core   +1 more source

Stable β2‐Microglobulin–HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer‐Associated Epitopes

European Journal of Immunology, Volume 56, Issue 5, May 2026.
We investigated differences in peptide repertoire when β2‐microglobulin is fused to the HLA‐I heavy chain. We observed: (1) that immunopeptidomes changed in this condition, (2) an overall increased median IC50 of the entire peptide repertoire, and (3) a reduced presentation of cancer‐specific epitopes with a strong predicted binding affinity for HLA‐I.
Ana Barajas Molina, Yehor Horokhovskyi, Nicole Acuti, Yee Kien Chong, Meghna Phanichkrivalkosil, Sophie Siddons, Hassnae Afrache, Megan Maloney, Wai Tuck Soh, Tom Hofland, Callum Hall, Henning Urlaub, George Kassiotis, Juliane Liepe, Michele Mishto   +14 more
wiley   +1 more source

Strucutral Characterization of ER aminopeptidase, ERAP1

The FASEB Journal, 2006
The endoplasmic reticulum (ER) aminopeptidase, ERAP1, is a 941 amino acid member of the M1 family of zinc metalloaminopeptidases. Unlike other aminopeptidases, ERAP1 exhibits a substrate length preference and a C‐terminal residue preference. ERAP1 has been suggested to have a molecular ruler mechanism because it trims peptides to lengths (8 or 9 amino ...
Tina T Nguyen, Lawrence J Stern
openaire   +1 more source

Polymorphism of the Endoplasmic Reticulum Aminopeptidase 1 Gene in Egyptian Patients with Rheumatoid Arthritis [PDF]

Zagazig University Medical Journal
Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease caused by the interplay of hereditary and environmental factors. Extreme polymorphism is assumed for the Endoplasmic Reticulum Aminopeptidase 1 Gene Polymorphism (ERAP1) gene.
Nora Said, asmaa saad, Nada Baraka, Mirvat Al toukhy, Lamiaa Abdel-Wehab   +4 more
doaj   +1 more source

Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK‐3β Axis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.
ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley   +1 more source

Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis

Annals of the Rheumatic Diseases, 2010
To assess whether there is excess transmission of alleles from the ERAP1 ERAP2 locus in families with ankylosing spondylitis (AS).199 multiplex families with AS with four non-synonymous single nucleotide polymorphisms (SNPs), three in the endoplasmic reticulum aminopeptidase 1 (ERAP1) gene (rs27044, rs10050860 and rs30187) and one in the endoplasmic ...
Florence W L, Tsui, Nigil, Haroon, John D, Reveille, Proton, Rahman, Basil, Chiu, Hing Wo, Tsui, Robert D, Inman   +6 more
openaire   +3 more sources

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source