Results 61 to 70 of about 5,215 (208)
Allergy, EarlyView.ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki +6 more
wiley +1 more source
Rheumatology & Autoimmunity, 2022 Objectives To determine the association of Human leukocyte antigen B (HLA‑B) alleles with ankylosing spondylitis and the allelic association of HLA‐B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single‐nucleotide polymorphism (SNP) rs30187 in ...
Md Kamrul H. Sajib +7 more
doaj +1 more source
Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design [PDF]
, 2014 The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells.
Boucau, Julie +4 more
core +2 more sources
British Journal of Pharmacology, EarlyView.Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire +28 more
wiley +1 more source
SLAS Discovery, 2023 MALDI-TOF MS is a powerful analytical technique that provides a fast and label-free readout for in vitro assays in the high-throughput screening (HTS) environment.
Leonie Müller +11 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley +1 more source
Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population [PDF]
, 2016 The initial GWAS was funded by the International Serious Adverse Events Consortium (iSAEC). The iSAEC is a non-profit organization dedicated to identifying and validating DNA variants useful in predicting the risk of drug-related serious adverse events ...
Alfirevic, A +23 more
core +6 more sources
Association of ERAP1 Allelic Variants with Risk of Ankylosing Spondylitis
Acta Naturae, 2010 Ankylosing spondylitis (AS) belongs to a group of autoimmune diseases affecting the axial skeleton. Beside thehla-b*27allele, several other human genes that control the variety processes of immune homeostasis are considered to be associated with AS manifestation in different human populations.
Zvyagin, I. +6 more
openaire +3 more sources
Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance The immune system performs surveillance to identify infected or cancerous cells through recognition of small protein fragments called antigenic peptides on their surface. To do this, the peptides must be cut to a specific length by an enzyme called endoplasmic reticulum aminopeptidase 1 (ERAP1).
Reeves, Emma +4 more
openaire +3 more sources
AIF-1 gene does not confer susceptibility to Behçet's disease: Analysis of extended haplotypes in Sardinian population [PDF]
, 2018 Background BehcEet's disease (BD) is a polygenic immune-mediated disorder characterized by a close association with the HLA-B∗51 allele. The HLA region has a strong linkage disequilibrium (LD) and carries several genetic variants (e.g. MIC-A, TNF-α genes)
Angioni, Mm +11 more
core +3 more sources