Results 11 to 20 of about 3,465 (162)

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia [PDF]

Frontiers in Immunology, 2020
Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta.
Kimberly Seamon, Lesia O. Kurlak, Michelle Warthan, Efstratios Stratikos, Jerome F. Strauss, Hiten D. Mistry, Eun D. Lee, Eun D. Lee   +7 more
doaj   +2 more sources

The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I

Scientific Reports, 2021
Processing of N-terminally elongated antigenic peptide precursors by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key step in antigen presentation and the adaptive immune response.
George Mavridis, Anastasia Mpakali, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou, Eleni Kaloumenou, Angeliki Ziotopoulou, Dimitris Georgiadis, Athanasios Papakyriakou, Efstratios Stratikos   +9 more
doaj   +2 more sources

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation

Frontiers in Immunology, 2022
Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou, Anastasia Mpakali, Efstratios Stratikos, Efstratios Stratikos   +3 more
doaj   +2 more sources

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1. [PDF]

PLoS ONE, 2008
BackgroundEndoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I molecules.
Irini Evnouchidou, Frank Momburg, Athanasios Papakyriakou, Angeliki Chroni, Leondios Leondiadis, Shih-Chung Chang, Alfred L Goldberg, Efstratios Stratikos   +7 more
doaj   +2 more sources

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP [PDF]

Nature Communications, 2019
ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from  βTrCP and promoting tumorigenesis through βTrCP ...
Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci, Lucia Di Marcotullio   +26 more
doaj   +8 more sources

Prognostic Impact of ERAP1 Genetic Variants and Haplotypes in Cervical Cancer: Insights From TCGA-CESC and a Brazilian Patient Cohort. [PDF]

Mol Genet Genomic Med
Overview of the study design and main findings on the prognostic impact of ERAP1 genetic variants, haplotypes, and expression in cervical cancer. Genetic and clinical data from TCGA‐CESC and a Brazilian patient cohort were analyzed to evaluate associations with survival outcomes.
Dian AL, Cunha APA, Melo CPS, Nascimento MDDSB, Carvalho MGR, Ruiz JC.   +5 more
europepmc   +2 more sources

Druggable genome-wide Mendelian randomization analysis identifies potential treatment targets in vascular dementia. [PDF]

Alzheimers Dement (N Y)
Abstract BACKGROUND There are currently no US Food and Drug Administration‐approved treatments for vascular dementia (VaD). Genome‐wide approaches have successfully identified druggable targets and treatments for various disorders. In this study, we performed druggable genome‐wide two‐sample Mendelian randomization (2SMR) analysis to identify possible ...
Lennon MJ, Xu Y, Thalamuthu A, Mather K, Sachdev PS.   +4 more
europepmc   +2 more sources

ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes. [PDF]

Immunology
ERAP1 is an intracellular aminopeptidase that edits antigenic peptides to be presented by MHC class I molecules and is found in distinct functional allotypes in individuals. To investigate how different disease‐associated ERAP1 allotypes affect the cellular immunopeptidome, we generated A375 melanoma cell clones carrying either allotype 2 or allotype ...
Nikopaschou M, Samiotaki M, Kannavou A, Angelis NV, Tsitsilonis O, Panayotou G, Stratikos E.   +6 more
europepmc   +2 more sources

Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers

Frontiers in Immunology, 2021
Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components.
Andrzej Wiśniewski, Maciej Sobczyński, Konrad Pawełczyk, Irena Porębska, Monika Jasek, Marta Wagner, Wanda Niepiekło-Miniewska, Aneta Kowal, Joanna Dubis, Natalia Jędruchniewicz, Piotr Kuśnierczyk   +10 more
doaj   +1 more source

Interferon Regulatory Factor 2 (IRF2) Suppression Enhances Murine Cardiac Allograft Survival Through Immune Evasion. [PDF]

Immunology
Our data show that suppressing IRF2, genetically or by siRNA, modulates PD‐L1 and MHC‐I levels. This induced immune‐evasive state critically underlies the significantly prolonged survival of cardiac allografts, revealing a novel therapeutic avenue.
Tian L, Zhang M, Guo Y, Chang S, Chen ZK, Zhou H.   +5 more
europepmc   +2 more sources