Results 11 to 20 of about 3,350 (175)

Impact of ERAP1 downregulation on the pathogenesis of DSS-induced colitis and therapeutic response to sulfasalazine [PDF]

Frontiers in Immunology
IntroductionUlcerative colitis (UC) is a life-threatening heterogeneous condition characterized by inflammation of the colon. Endoplasmic reticulum aminopeptidase 1 (ERAP1) is essential for antigen processing and immune regulation, however, its specific ...
Bushra Riaz, Bushra Riaz, Hye-Myung Ryu, S. M. Shamsul Islam, Rahar Babita, Je Kyung Seong, Je Kyung Seong, Je Kyung Seong, Ho Lee, Eunjoo H. Lee, Seonghyang Sohn, Seonghyang Sohn, Seonghyang Sohn   +12 more
doaj   +5 more sources

Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma [PDF]

Journal of Experimental & Clinical Cancer Research
Background Checkpoint immunotherapy unleashes tumor control by T cells, but it is undermined in non-immunogenic tumors, e.g. with low MHC class I expression and low neoantigen burden, such as neuroblastoma (NB).
Patrizia Tempora, Silvia D’Amico, Paula Gragera, Verena Damiani, Kamila Krol, Valentina Scaldaferri, Kirti Pandey, Shanzou Chung, Valeria Lucarini, Ezio Giorda, Marco Scarsella, Gabriele Volpe, Marco Pezzullo, Cristiano De Stefanis, Valentina D’Oria, Lorenzo De Angelis, Roberto Giovannoni, Maria Antonietta De Ioris, Ombretta Melaiu, Anthony W. Purcell, Franco Locatelli, Doriana Fruci   +21 more
doaj   +3 more sources

The role of polymorphic ERAP1 in autoinflammatory disease [PDF]

Bioscience Reports, 2018
Autoimmune and autoinflammatory conditions represent a group of disorders characterized by self-directed tissue damage due to aberrant changes in innate and adaptive immune responses. These disorders possess widely varying clinical phenotypes and etiology; however, they share a number of similarities in genetic associations and environmental influences.
Reeves, Emma, James, Edward
openaire   +5 more sources

ERAP1 and ankylosing spondylitis

Current Opinion in Immunology, 2013
The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), which is restricted to HLA-B27 positive cases, has profound pathogenetic implications. ERAP1 is involved in trimming peptides to optimal length for binding to HLA class 1 molecules, thereby not only affecting the stability and processing ...
Keidel, S, Chen, L, Pointon, J, Wordsworth, B   +3 more
openaire   +4 more sources

Investigating the genetic association between ERAP1 and ankylosing spondylitis [PDF]

Human Molecular Genetics, 2009
A strong association between ERAP1 and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Australo-Anglo-American Spondylitis Consortium (WTCCC-TASC) study. ERAP1 is highly polymorphic with strong linkage disequilibrium evident across the gene.
Harvey, David, Pointon, Jennifer J., Evans, David M., Karaderi, Tugce, Farrar, Claire, Appleton, Louise H., Sturrock, Roger D., Stone, Millicent A., Oppermann, Udo, Brown, Matthew A., Wordsworth, B. Paul   +10 more
openaire   +7 more sources

ERAP1: a potential therapeutic target for a myriad of diseases

Expert Opinion on Therapeutic Targets, 2020
Introduction: Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key regulator of the peptide repertoire displayed by Major Histocompatibility Complex I (MHC I) to circulating CD8 + T cells and NK cells. Studies have highlighted the essential requirement for the generation of stable peptide MHC I in regulating both innate and adaptive immune responses
Emma, Reeves, Yasmin, Islam, Edward, James   +2 more
core   +6 more sources

ERAP1 inhibitor development [PDF]

, 2017
ERAP1 has been associated with a set of immune-mediated diseases, including ankylosing spondylitis. Currently, there is no selective and potent ERAP1 inhibitor available that would allow in-depth research of its functions and roles in diseases. Therefore, the aim of this work is to apply fragment-based drug design approach for the development of such ...
Guzanov, Pavel, Pavel Guzanov
openaire   +3 more sources

Druggable genome‐wide Mendelian randomization analysis identifies potential treatment targets in vascular dementia [PDF]

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract BACKGROUND There are currently no US Food and Drug Administration‐approved treatments for vascular dementia (VaD). Genome‐wide approaches have successfully identified druggable targets and treatments for various disorders. In this study, we performed druggable genome‐wide two‐sample Mendelian randomization (2SMR) analysis to identify possible ...
Matthew J. Lennon, Ying Xu, Anbupalam Thalamuthu, Karen Mather, Perminder S. Sachdev   +4 more
wiley   +2 more sources

Interferon Regulatory Factor 2 (IRF2) Suppression Enhances Murine Cardiac Allograft Survival Through Immune Evasion [PDF]

Immunology, Volume 177, Issue 4, Page 752-765, April 2026.
Our data show that suppressing IRF2, genetically or by siRNA, modulates PD‐L1 and MHC‐I levels. This induced immune‐evasive state critically underlies the significantly prolonged survival of cardiac allografts, revealing a novel therapeutic avenue.
Li Tian, Man Zhang, Yuliang Guo, Sheng Chang, Zhonghua Klaus Chen, Hongmin Zhou   +5 more
wiley   +2 more sources

Association of ERAP1 and IL23R gene polymorphisms with ankylosing spondylitis [PDF]

Современная ревматология, 2020
Currently, the causes of extra-axial and extra-skeletal manifestations of ankylosing spondylitis (AS) and the possible impact of genetic aspects on its course and clinical features remain unresolved.Objective: to investigate the association of the ...
U. A. Yakubova, O. V. Bugrova, K. A. Nagornova   +2 more
doaj   +2 more sources