Results 11 to 20 of about 5,215 (208)

ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes. [PDF]

Immunology
ERAP1 is an intracellular aminopeptidase that edits antigenic peptides to be presented by MHC class I molecules and is found in distinct functional allotypes in individuals. To investigate how different disease‐associated ERAP1 allotypes affect the cellular immunopeptidome, we generated A375 melanoma cell clones carrying either allotype 2 or allotype ...
Nikopaschou M, Samiotaki M, Kannavou A, Angelis NV, Tsitsilonis O, Panayotou G, Stratikos E.   +6 more
europepmc   +3 more sources

Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma [PDF]

Analytical Cellular Pathology, 2015
The antigen processing machinery (APM) plays an important role in immune recognition of virally infected and transformed cells. Defective expression of the APM component ERAP1 is associated with progression and poor clinical outcome in cervical carcinoma.
Akash M. Mehta, Michelle Osse, Sandra Kolkman-Uljee, Gert Jan Fleuren, Ekaterina S. Jordanova   +4 more
doaj   +5 more sources

Expression and role of ERAP1 in placental tissues of preeclampsia

Hypertension in Pregnancy, 2020
Objective This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis. Methods ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot.
Yanyan Xu, Junjiao Wu, Jianbo Wu
doaj   +3 more sources

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation

Frontiers in Immunology, 2022
Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou, Anastasia Mpakali, Efstratios Stratikos, Efstratios Stratikos   +3 more
doaj   +4 more sources

The Role of Aminopeptidase ERAP1 in Human Pathology—A Review

Current Issues in Molecular Biology
Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic
Laura Țiburcă, Dana Carmen Zaha, Maria Claudia Jurca, Emilia Severin, Aurora Jurca, Alexandru Daniel Jurca   +5 more
doaj   +3 more sources

Interferon Regulatory Factor 2 (IRF2) Suppression Enhances Murine Cardiac Allograft Survival Through Immune Evasion. [PDF]

Immunology
Our data show that suppressing IRF2, genetically or by siRNA, modulates PD‐L1 and MHC‐I levels. This induced immune‐evasive state critically underlies the significantly prolonged survival of cardiac allografts, revealing a novel therapeutic avenue.
Tian L, Zhang M, Guo Y, Chang S, Chen ZK, Zhou H.   +5 more
europepmc   +2 more sources

Estimation of endoplasmic reticulum aminopeptidase 1 level of expression in lesional and nonlesional skin of psoriatic patients and healthy controls

Journal of the Egyptian Women’s Dermatologic Society, 2021
Background Psoriasis is a chronic inflammatory autoimmune disease of the skin, in which an elevated expression of endoplasmic reticulum aminopeptidase 1 (ERAP1), an enzyme involved in the final processing of major histocompatibility complex-I ligands ...
Dina Metwally, Laila A Rashed, Amul M Badr, Doaa M Elqadi, Rana F Hilal   +4 more
doaj   +1 more source

Endoplasmic Reticulum Aminopeptidase 1 Is Involved in Anti-viral Immune Response of Hepatitis B Virus by Trimming Hepatitis B Core Antigen to Generate 9-Mers Peptides

Frontiers in Microbiology, 2022
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a processing enzyme of antigenic peptides presented to major histocompatibility complex (MHC) class I molecules.
Huanhuan Liu, Bingqi Hu, Junfeng Huang, Qin Wang, Feier Wang, Faming Pan, Liwen Chen   +6 more
doaj   +1 more source

ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function

Frontiers in Immunology, 2021
The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by major histocompatibility complex (MHC) class I molecules.
Silvia D’Amico, Valerio D’Alicandro, Mirco Compagnone, Patrizia Tempora, Giusy Guida, Paolo Romania, Valeria Lucarini, Ombretta Melaiu, Michela Falco, Mattia Algeri, Daniela Pende, Loredana Cifaldi, Loredana Cifaldi, Doriana Fruci   +13 more
doaj   +1 more source

Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers

Frontiers in Immunology, 2021
Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components.
Andrzej Wiśniewski, Maciej Sobczyński, Konrad Pawełczyk, Irena Porębska, Monika Jasek, Marta Wagner, Wanda Niepiekło-Miniewska, Aneta Kowal, Joanna Dubis, Natalia Jędruchniewicz, Piotr Kuśnierczyk   +10 more
doaj   +1 more source