Results 31 to 40 of about 1,626 (143)

ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19? [PDF]

International Journal of Molecular Sciences, 2021
Patients with coronavirus disease 2019 (COVID-19) have a wide variety of clinical outcomes ranging from asymptomatic to severe respiratory syndrome that can progress to life-threatening lung lesions. The identification of prognostic factors can help to improve the risk stratification of patients by promptly defining for each the most effective therapy ...
Silvia D’Amico, Patrizia Tempora, Valeria Lucarini, Ombretta Melaiu, Stefania Gaspari, Mattia Algeri, Doriana Fruci   +6 more
openaire   +5 more sources

To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2

Frontiers in Immunology, 2022
To be, or not to be, that is the question. (William Shakespeare, Hamlet)Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2, respectively) play a role in trimming peptides that are too long to be bound and presented by class I HLA (HLA-I ...
Piotr Kuśnierczyk
doaj   +1 more source

ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency [PDF]

The Journal of Immunology, 2014
Abstract The endoplasmic reticulum aminopeptidases (ERAP)1 and ERAP2 play a critical role in the production of final epitopes presented by MHC class I molecules. Formation of heterodimers by ERAP1 and ERAP2 has been proposed to facilitate trimming of epitope precursor peptides, but the effects of dimerization on ERAP function remain ...
Irini, Evnouchidou, Mirjana, Weimershaus, Loredana, Saveanu, Peter, van Endert   +3 more
openaire   +2 more sources

Phenylsulfamoyl Benzoic Acid Inhibitor of ERAP2 with a Novel Mode of Inhibition

ACS Chemical Biology, 2022
ERAP1 and ERAP2 are endoplasmic reticulum zinc-binding aminopeptidases that play crucial roles in processing peptides for loading onto class I major histocompatibility complex proteins. These enzymes are therapeutic targets in cancer and autoimmune disorders.
Richa Arya, Zachary Maben, Digamber Rane, Akbar Ali, Lawrence J. Stern   +4 more
openaire   +2 more sources

Functional studies of ERAP2 associated with risk of autoimmune diseases

Romanian Journal of Rheumatology, 2018
Autoimmune sykdommer er svært utbredt i den globale populasjonen (ca. 5-10%), og forekomsten blir stadig hyppigere. Sykdommene påvirkes av genetiske risikofaktorer, miljøfaktorer og epigenetisk innflytelse, dette har gjort det vanskelig å diagnostisere pasienter.
Laura Ioana Cherciu, Marius Cherciu, Luis Ovidiu Popa, Mihai Bojinca, Monica Irina Dutescu, Violeta Bojinca, Constantin Bara, Olivia Mihaela Popa   +7 more
  +11 more sources

Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. [PDF]

PLoS Genetics, 2010
A remarkable characteristic of the human major histocompatibility complex (MHC) is its extreme genetic diversity, which is maintained by balancing selection.
Aida M Andrés, Megan Y Dennis, Warren W Kretzschmar, Jennifer L Cannons, Shih-Queen Lee-Lin, Belen Hurle, NISC Comparative Sequencing Program, Pamela L Schwartzberg, Scott H Williamson, Carlos D Bustamante, Rasmus Nielsen, Andrew G Clark, Eric D Green   +12 more
doaj   +1 more source

ERAP, KIR, and HLA-C Profile in Recurrent Implantation Failure

Frontiers in Immunology, 2021
The mother’s uterine immune system is dominated by uterine natural killer (NK) cells during the first trimester of pregnancy. These cells express killer cell immunoglobulin-like receptors (KIRs) of inhibitory or activating function. Invading extravillous
Karolina Piekarska, Paweł Radwan, Agnieszka Tarnowska, Andrzej Wiśniewski, Michał Radwan, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Andrzej Malinowski, Izabela Nowak   +9 more
doaj   +1 more source

Association of ERAP2 polymorphisms in Colombian HLA-B27+ or HLA-B15+ patients with SpA and its relationship with clinical presentation: axial or peripheral predominance

RMD Open, 2020
Objective To determine the association between endoplasmic reticulum aminopeptidase (ERAP)1 and ERAP2 single-nucleotide polymorphisms (SNPs) and human leukocyte antigens (HLA)-B27+ or HLA-B15+ patients with spondyloarthritis (SpA).Methods 104 patients ...
Ruben Burgos-Vargas, John Londono, Ana M Santos, Juan C Rueda, Enrique Calvo-Paramo, Gilberto Vargas-Alarcon, Nancy Martinez-Rodriguez, Sofia Arias-Correal, Guisselle-Nathalia Muñoz, Diana Padilla, Francy Cuervo, Viviana Reyes-Martinez, Santiago Bernal-Macías, Catalina Villota-Eraso, Luz M Avila-Portillo, Consuelo Romero, Juan F Medina   +16 more
doaj   +1 more source

The Impact of ERAP1 and ERAP2 Haplotype Combinations on Susceptibility and Severity of Birdshot Chorioretinitis. [PDF]

Invest Ophthalmol Vis Sci
To investigate how ERAP1 and ERAP2 genotype combinations influence susceptibility and severity in birdshot chorioretinitis (BSCR), an HLA-A29-associated disease with variable visual outcomes.We analyzed ERAP1 and ERAP2 haplotypes in 406 HLA-A29-positive BSCR patients and 106 HLA-A29-positive controls.
Loeliger J, Gelfman S, Stahl EA, Moscati A, Bai X, Monnet D, Imikirene L, Kecili S, Tabary T, Cohen J, Brézin AP.   +10 more
europepmc   +3 more sources

Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis

Annals of the Rheumatic Diseases, 2010
To assess whether there is excess transmission of alleles from the ERAP1 ERAP2 locus in families with ankylosing spondylitis (AS).199 multiplex families with AS with four non-synonymous single nucleotide polymorphisms (SNPs), three in the endoplasmic reticulum aminopeptidase 1 (ERAP1) gene (rs27044, rs10050860 and rs30187) and one in the endoplasmic ...
Florence W L, Tsui, Nigil, Haroon, John D, Reveille, Proton, Rahman, Basil, Chiu, Hing Wo, Tsui, Robert D, Inman   +6 more
openaire   +3 more sources