Frontiers in Immunology, 2019 Background: Haplotype-specific alternative splicing of the endoplasmic reticulum (ER) aminopeptidase type 2 (ERAP2) gene results in either full-length (FL, haplotype A) or alternatively spliced (AS, haplotype B) mRNA.
Mario Clerici +2 more
exaly +3 more sources
An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis [PDF]
Communications BiologyPsoriatic arthritis (PsA) is a complex, chronic immune-mediated inflammatory arthropathy that currently lacks definitive biomarkers and treatment targets. Identifying biomarkers and treatment targets is urgently needed for effectively managing PsA. Here,
Yi-Xin Cai +6 more
doaj +2 more sources
The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report [PDF]
Frontiers in PharmacologyIdiosyncratic hepatotoxicity is a type of drug-induced liver injury (DILI) that is unpredictable and clinically severe, and amoxicillin clavulanate (AC) is the most implicated drug in DILI worldwide. The clinical manifestations of amoxicillin clavulanate-
Yan Zhan +18 more
doaj +2 more sources
Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization [PDF]
BMC Pulmonary MedicineBackground Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Current options such as glucocorticoids and bronchodilators improve symptoms but carry risks, including infection and immunosuppression. To guide safer,
Qinyao Jia +6 more
doaj +2 more sources
Integrative genomic analysis identifies novel causal genes of Hodgkin’s and non-Hodgkin’s lymphoma [PDF]
Discover OncologyBackground The genetic mechanisms underlying non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) remain understudied. While numerous genes associated with these lymphoid tumors have been identified, little research has focused on the genetic networks ...
Patrick Shi, Ancha Baranova, Hongbao Cao
doaj +2 more sources
How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins [PDF]
Frontiers in Immunology, 2018 Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A*29:02), ankylosing spondylitis (HLA-B*27), Behçet's disease (HLA-B*51), and psoriasis (HLA-C*06:02). The
José A. López de Castro
doaj +4 more sources
Identification and Experimental Validation of PANoptosis Key Genes for Constructing a PANoptosis Risk Diagnostic Model in Intervertebral Disc Degeneration. [PDF]
J Gene MedThis study identified seven PANoptosis key genes (ACSBG1, FXYD1, APCS, CEACAM1, ERAP2, ABL1, and FZD3) in intervertebral disc degeneration (IDD) through integrated bioinformatics analysis of GEO datasets. Using machine learning algorithms (RF, SVM, XGB, and GLM), a PANoptosis risk diagnostic model was constructed and validated.
Deng K, Lan X, Chen W, Du L, Chen J.
europepmc +2 more sources
Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2)
Genes & Immunity, 2023 AbstractEndoplasmic reticulum aminopeptidase 2 (ERAP2) is a proteolytic enzyme involved in adaptive immunity. The ERAP2 gene is highly polymorphic and encodes haplotypes that confer resistance against lethal infectious diseases, but also increase the risk for autoimmune disorders. Identifying how ERAP2 influences susceptibility to these traits requires
Aroosha Raja, Jonas J. W. Kuiper
openaire +5 more sources
Exploring the Genetic Interaction Between ERAP1/ERAP2 and HLA-B*52:01 In Takayasu Arteritis [PDF]
RheumatologyPeter A Merkel +2 more
exaly +2 more sources
The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations [PDF]
Human Genetics, 2009 Preeclampsia is a heritable pregnancy disorder that presents new onset hypertension and proteinuria. We have previously reported genetic linkage to preeclampsia on chromosomes 2q, 5q and 13q in an Australian/New Zealand (Aust/NZ) familial cohort. This current study centered on identifying the susceptibility gene(s) at the 5q locus. We first prioritized
Johnson, M. +8 more
openaire +5 more sources