The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia [PDF]
Frontiers in Immunology, 2020 Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta.
Kimberly Seamon +7 more
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Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization [PDF]
BMC Pulmonary MedicineBackground Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Current options such as glucocorticoids and bronchodilators improve symptoms but carry risks, including infection and immunosuppression. To guide safer,
Qinyao Jia +6 more
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Integrative genomic analysis identifies novel causal genes of Hodgkin’s and non-Hodgkin’s lymphoma [PDF]
Discover OncologyBackground The genetic mechanisms underlying non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) remain understudied. While numerous genes associated with these lymphoid tumors have been identified, little research has focused on the genetic networks ...
Patrick Shi, Ancha Baranova, Hongbao Cao
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Endoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis [PDF]
Arthritis Research & TherapyObjective Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a complex pathogenesis that has not yet been fully elucidated, and T-cell pyroptosis is an important pathogenetic factor in RA. This study aimed to investigate the role
Jianhua Zhang +9 more
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Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese [PDF]
Frontiers in Genetics, 2020 Single nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase (ERAP1 and ERAP2) genes are associated with the pathogenesis of bacterial and viral infections.
Shuqiong Zhang +12 more
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How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins [PDF]
Frontiers in Immunology, 2018 Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A*29:02), ankylosing spondylitis (HLA-B*27), Behçet's disease (HLA-B*51), and psoriasis (HLA-C*06:02). The
José A. López de Castro
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A deep learning‐based deconvolution framework identifies human brain cell‐type specific expression quantitative trait loci (eQTLs) and pathobiology in Alzheimer’s disease [PDF]
Alzheimers DementAbstract Background Cell‐type specific expression quantitative trait loci (eQTLs) can help dissect cellular heterogeneity in the impact of genetic variation on gene expression for Alzheimer’s disease (AD) and AD‐related dementia (ADRD). However, due to the high cost and stringent sample collection criteria, it is challenging to obtain large single ...
Dou L, Xu J, Hou Y, Cheng F.
europepmc +2 more sources
The Role of Aminopeptidase ERAP1 in Human Pathology—A Review [PDF]
Current Issues in Molecular BiologyAminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic
Laura Țiburcă +5 more
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Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2). [PDF]
Genes Immun, 2023 AbstractEndoplasmic reticulum aminopeptidase 2 (ERAP2) is a proteolytic enzyme involved in adaptive immunity. The ERAP2 gene is highly polymorphic and encodes haplotypes that confer resistance against lethal infectious diseases, but also increase the risk for autoimmune disorders. Identifying how ERAP2 influences susceptibility to these traits requires
Raja A, Kuiper JJW.
europepmc +4 more sources
ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency [PDF]
The Journal of Immunology, 2014 Abstract The endoplasmic reticulum aminopeptidases (ERAP)1 and ERAP2 play a critical role in the production of final epitopes presented by MHC class I molecules. Formation of heterodimers by ERAP1 and ERAP2 has been proposed to facilitate trimming of epitope precursor peptides, but the effects of dimerization on ERAP function remain ...
Irini, Evnouchidou +3 more
openaire +2 more sources