The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response [PDF]
Journal of Translational MedicineBackground ERAP2 is an aminopeptidase involved in antigen processing and presentation, and harbor genetic variants linked to several inflammatory diseases such as Inflammatory Bowel Disease (IBD).
Siri Sæterstad +4 more
doaj +5 more sources
Unveiling the impact of ERAP1 and ERAP2 on migration, angiogenesis and ER stress response [PDF]
Frontiers in Cell and Developmental BiologyRecent studies have investigated the key roles exerted by ERAP1 and ERAP2 in maintaining cellular homeostasis, emphasizing their functions beyond traditional antigen processing and presentation.
Irma Saulle +6 more
doaj +4 more sources
The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease [PDF]
Frontiers in Immunology, 2020 In the human genome, the aminopeptidases ERAP1, ERAP2 and LNPEP lie contiguously on chromosome 5. They share sequence homology, functions and associations with immune-mediated diseases.
Fabiana Paladini +2 more
exaly +6 more sources
THE ASSOCIATION OF ERAP2 GENE POLYMORPHISMS WITH SERONEGATIVE SPONDYLOARTHROPATHIES IN HLA-B27 NEGATIVE ROMANIANS [PDF]
Romanian Journal of Rheumatology, 2016 Objective. Our aim was to investigate whether two ERAP2 single nucleotide polymorphisms (rs2910686 and rs2248374) influence spondyloarthritis (SpA) susceptibility in Romanians. Methods.
Laura Ioana Cherciu +7 more
doaj +16 more sources
Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
Frontiers in Immunology, 2022 Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou +3 more
doaj +4 more sources
The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Frontiers in Immunology, 2022 IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban +6 more
doaj +3 more sources
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. [PDF]
PLoS Genetics, 2010 A remarkable characteristic of the human major histocompatibility complex (MHC) is its extreme genetic diversity, which is maintained by balancing selection.
Aida M Andrés +12 more
doaj +5 more sources
An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis [PDF]
Communications BiologyPsoriatic arthritis (PsA) is a complex, chronic immune-mediated inflammatory arthropathy that currently lacks definitive biomarkers and treatment targets. Identifying biomarkers and treatment targets is urgently needed for effectively managing PsA. Here,
Yi-Xin Cai +6 more
doaj +2 more sources
The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report [PDF]
Frontiers in PharmacologyIdiosyncratic hepatotoxicity is a type of drug-induced liver injury (DILI) that is unpredictable and clinically severe, and amoxicillin clavulanate (AC) is the most implicated drug in DILI worldwide. The clinical manifestations of amoxicillin clavulanate-
Yan Zhan +18 more
doaj +2 more sources
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women [PDF]
Scientific Reports, 2021 The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown.
Leonardo Capistrano Ferreira +6 more
doaj +3 more sources