The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response [PDF]
Journal of Translational MedicineBackground ERAP2 is an aminopeptidase involved in antigen processing and presentation, and harbor genetic variants linked to several inflammatory diseases such as Inflammatory Bowel Disease (IBD).
Siri Sæterstad +4 more
doaj +5 more sources
Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese [PDF]
Frontiers in Genetics, 2020 Single nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase (ERAP1 and ERAP2) genes are associated with the pathogenesis of bacterial and viral infections.
Li Shi, Shuyuan Liu, Yufeng Yao
exaly +5 more sources
The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease [PDF]
Frontiers in Immunology, 2020 In the human genome, the aminopeptidases ERAP1, ERAP2 and LNPEP lie contiguously on chromosome 5. They share sequence homology, functions and associations with immune-mediated diseases.
Maria Teresa Fiorillo +2 more
exaly +6 more sources
The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Frontiers in Immunology, 2022 IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban +6 more
doaj +3 more sources
Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
Frontiers in Immunology, 2022 Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou +3 more
doaj +4 more sources
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women [PDF]
Scientific Reports, 2021 The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown.
Leonardo Capistrano Ferreira +6 more
doaj +3 more sources
The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia [PDF]
Frontiers in Immunology, 2020 Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta.
Kimberly Seamon +7 more
doaj +3 more sources
A Cis-Regulatory Element Regulates ERAP2 Expression Through Autoimmune Disease Risk SNPs
Cell GenomicsSummary: Single-nucleotide polymorphisms (SNPs) near the ERAP2 gene are associated with various autoimmune conditions, as well as protection against lethal infections. Due to high linkage disequilibrium, numerous trait-associated SNPs are correlated with
Wouter Venema +2 more
exaly +3 more sources
The hypothalamic-neurohypophyseal system in preeclampsia: a systematic review with a subgroup meta-analysis of copeptin levels worldwide [PDF]
Frontiers in EndocrinologyLiterature has reported elevated concentrations of copeptin (CPP), a marker of arginine vasopressin (AVP) secretion, preceding the clinical features of the life-threatening condition, preeclampsia (PE).
Gustavo M. Moreira +8 more
doaj +2 more sources
Fetal
BMC Medical Genetics, 2011 Background Preeclampsia affects 3-8% of pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. This complex disorder is characterized by alterations in the immune and vascular systems and involves multiple organs ...
Elovitz Michal A +8 more
doaj +4 more sources