Results 41 to 50 of about 1,626 (143)
Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity. [PDF]
Immunol RevABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Shrestha C, Weisfelder HM, Do TD.
europepmc +2 more sources
ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes
Molecular Immunology, 2023 The therapy of cancer by adoptive T cell transfer (ACT) requires T cell receptors (TCRs) with optimal affinity for HLA class I-bound peptides (pHLA-I). But not every patient responds to ACT. Therefore, it is critical to understand the individual factors influencing the recognition of HLA class I-bound peptides (pHLA-I) by TCRs.
Karin, Schmidt +2 more
openaire +2 more sources
Aging, 2022 Abstract Background Pancreatic cancer is one of the most malignant tumors, with rapid metastasis, high mortality rate, and difficult early screening. Currently, gemcitabine is a first-line drug for pancreatic cancer patients, but its clinical effect is limited due to drug resistance.
Yu, Pian +4 more
openaire +2 more sources
THE ASSOCIATION OF ERAP2 GENE POLYMORPHISMS WITH SERONEGATIVE SPONDYLOARTHROPATHIES IN HLA-B27 NEGATIVE ROMANIANS [PDF]
Romanian Journal of Rheumatology, 2016 Objective. Our aim was to investigate whether two ERAP2 single nucleotide polymorphisms (rs2910686 and rs2248374) influence spondyloarthritis (SpA) susceptibility in Romanians. Methods.
Laura Ioana Cherciu +7 more
doaj +1 more source
Autoimmune risk variants in ERAP2 are associated with gene-expression levels in thymus [PDF]
Genes & Immunity, 2016 Genetic polymorphisms in the endoplasmic reticulum aminopeptidase (ERAP)1 and ERAP2 genes have been associated with several autoimmune diseases (AIDs) at a genome-wide significance level. In this study, we performed a cis expression quantitative trait locus (eQTL) screen to investigate whether seven fine-mapped AID single-nucleotide polymorphisms (SNPs)
I S M, Gabrielsen +6 more
openaire +2 more sources
BMC Cancer, 2020 Background Antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that polymorphisms in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins and ...
Chuanyin Li +9 more
doaj +1 more source
, 2023 Abstract Ankylosing Spondylitis is an autoimmune disease leading to inflammation in the joints and ligaments of the spine. ERAP1 is a major risk factor for AS and ERAP1 mutations may result in structural changes that alter the trimming efficiency, thereby altering the immune response. The underlying structural mechanisms of AS pathogenesis have
Yunus Emre Dilek +7 more
openaire +1 more source
Concerted in vitro trimming of viral HLA-B27-restricted ligands by human ERAP1 and ERAP2 aminopeptidases. [PDF]
PLoS ONE, 2013 In the classical human leukocyte antigen (HLA) class I antigen processing and presentation pathway, the antigenic peptides are generated from viral proteins by multiple proteolytic cleavages of the proteasome (and in some cases other cytosolic proteases)
Elena Lorente +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components.
Andrzej Wiśniewski +10 more
doaj +1 more source
Frontiers in Chemistry, 2021 A new bisbenzylisoquinoline named as chondrofolinol (1) and four reported compounds (2–5) were isolated and characterized from the roots of Berberis glaucocarpa Stapf.
Muhammad Alamzeb +10 more
doaj +1 more source