Results 51 to 60 of about 2,874 (176)

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population [PDF]

, 2016
The initial GWAS was funded by the International Serious Adverse Events Consortium (iSAEC). The iSAEC is a non-profit organization dedicated to identifying and validating DNA variants useful in predicting the risk of drug-related serious adverse events ...
Alfirevic, A, Borgiani, P, Bourgeois, S, Carr, DF, Castro, EMC, Chaponda, M, Dandara, C, Deloukas, P, Haldenby, S, Heyderman, RS, Holden, A, Jones, AR, Kampira, E, Khoo, S, Lalloo, DG, Morris, AP, Munderi, P, Nelson, MR, Novelli, G, Pirmohamed, M, Rigden, DJ, Ssali, F, Takeshita, LY, van Oosterhout, JJ   +23 more
core   +6 more sources

Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population

BMC Cancer, 2020
Background Antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that polymorphisms in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins and ...
Chuanyin Li, Yaheng Li, Zhiling Yan, Shuying Dai, Shuyuan Liu, Xia Wang, Jun Wang, Xinwen Zhang, Li Shi, Yufeng Yao   +9 more
doaj   +1 more source

Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers

Frontiers in Immunology, 2021
Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components.
Andrzej Wiśniewski, Maciej Sobczyński, Konrad Pawełczyk, Irena Porębska, Monika Jasek, Marta Wagner, Wanda Niepiekło-Miniewska, Aneta Kowal, Joanna Dubis, Natalia Jędruchniewicz, Piotr Kuśnierczyk   +10 more
doaj   +1 more source

Expression analysis of HLA-E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis [PDF]

, 2018
Background. Ankylosing Spondylitis (AS) is a complex chronic inflammatory disease strongly associated with the majority of HLA-B27 alleles. HLA-E are non-classical MHC class I molecules that specifically interact with the natural killer receptors NKG2A ...
Angioni, Mm, Cauli, A, Congia, M, Dessole, G, Fiorillo, Mt, Floris, A, Mascia, E, Mathieu, A., Paladini, F, Piga, M, Pinna, S, Sorrentino, R, Tedeschi, V   +12 more
core   +1 more source

Stereoselective synthesis of α-amino-C-phosphinic acids and derivatives [PDF]

, 2016
α-Amino-C-phosphinic acids and derivatives are an important group of compounds of synthetic and medicinal interest and particular attention has been dedicated to their stereoselective synthesis in recent years. Among these, phosphinic pseudopeptides have
Cativiela, Carlos, Ordóñez, Mario, Sayago, Francisco J., Viveros-Ceballos, José Luis   +3 more
core   +3 more sources

Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study

BMC Medical Genetics, 2011
Background Preeclampsia affects 3-8% of pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. This complex disorder is characterized by alterations in the immune and vascular systems and involves multiple organs ...
Elovitz Michal A, Gomez Ricardo, Kusanovic Juan P, Srinivas Sindhu, York Timothy P, Hilliard DaShaunda D, Hill Lori D, Romero Roberto, Strauss Jerome F   +8 more
doaj   +1 more source

Concerted in vitro trimming of viral HLA-B27-restricted ligands by human ERAP1 and ERAP2 aminopeptidases. [PDF]

PLoS ONE, 2013
In the classical human leukocyte antigen (HLA) class I antigen processing and presentation pathway, the antigenic peptides are generated from viral proteins by multiple proteolytic cleavages of the proteasome (and in some cases other cytosolic proteases)
Elena Lorente, Alejandro Barriga, Carolina Johnstone, Carmen Mir, Mercedes Jiménez, Daniel López   +5 more
doaj   +1 more source

Spectral, Anti-Inflammatory, Anti-Pyretic, Leishmanicidal, and Molecular Docking Studies, Against Selected Protein Targets, of a New Bisbenzylisoquinoline Alkaloid

Frontiers in Chemistry, 2021
A new bisbenzylisoquinoline named as chondrofolinol (1) and four reported compounds (2–5) were isolated and characterized from the roots of Berberis glaucocarpa Stapf.
Muhammad Alamzeb, William N. Setzer, Saqib Ali, Behramand Khan, Mamoon-Ur- Rashid, Ihsanullah, Syed Muhammad Salman, Adnan, Muhammad Omer, Javed Ali, Asad Ullah   +10 more
doaj   +1 more source

New insights into the genetic component of non-infectious uveitis through an Immunochip strategy [PDF]

, 2016
Background: Large-scale genetic studies have reported several loci associated with specific disorders involving uveitis. Our aim was to identify genetic risk factors that might predispose to uveitis per se, independent of the clinical diagnosis, by ...
Adán, Alfredo, Atan, Denize, Blanco, Ana, Blanco, Ricardo, Capella, María José, Cordero, Yolanda, Cordero-Coma, Miguel, De Boer, Joke H, Del Rio, María José, Dick, Andrew D, Díaz Valle, David, Díaz-Llopis, Manuel, Fonollosa, Alejandro, Gorroño-Echebarría, Marina Begoña, Kuiper, Jonas, Llorenç, Víctor, Martín, Javier, Martín-Villa, José Manuel, Márquez, Ana, Olea, Jose Luis, Ortego-Centeno, Norberto, Rothova, Aniki, Ruiz-Arruza, Ioana, Ten Berge, Josianne   +23 more
core   +2 more sources

Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic Analysis

Frontiers in Cell and Developmental Biology, 2022
The clinical management of patients with COVID-19 and cancer is a Gordian knot that has been discussed widely but has not reached a consensus. We introduced two-sample Mendelian randomization to investigate the causal association between a genetic ...
Yiyin Zhang, Qijiang Mao, Yirun Li, Jiaxi Cheng, Qiming Xia, Guoqiao Chen, Peng Chen, Shengxi Jin, Duguang Li, Cheng Zhong, Jing Yang, Xiaoxiao Fan, Xiaoxiao Fan, Yuelong Liang, Hui Lin, Hui Lin   +15 more
doaj   +1 more source