Results 71 to 80 of about 1,626 (143)

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

iPSC‐derived human cortical organoids display profound alterations of cellular homeostasis following SARS‐CoV‐2 infection and Spike protein exposure

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Graphical representation of the study workflow. iPSC‐derived human cortical organoids (HCOs) at Day 40, were in vitro infected by SARS‐CoV‐2 or exposed to the Spike protein and viral infection/replication was assessed by a multidisciplinary approach using RT‐qPCR, TCID50, and immunofluorescence.
Gioia Cappelletti, Lorenzo Brambilla, Sergio Strizzi, Fiona Limanaqi, Valentina Melzi, Mafalda Rizzuti, Monica Nizzardo, Irma Saulle, Daria Trabattoni, Stefania Corti, Mario Clerici, Mara Biasin   +11 more
wiley   +1 more source

Genetic and Genomic Approaches to the Study of Drug‐Induced Liver Injury

Liver International, Volume 45, Issue 1, January 2025.
ABSTRACT Idiosyncratic hepatotoxicity induced by prescribed drugs has been known since the early 20th century. Identifying risk factors, including genetic factors, that trigger this drug‐induced liver injury (DILI) has been an important priority for many years, both to prevent drugs that cause liver injury being licensed and as a potential means of ...
Ann K. Daly
wiley   +1 more source

RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?

Frontiers in Immunology, 2019
Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and ...
Matteo Vecellio, Matteo Vecellio, Matteo Vecellio, Carla J. Cohen, Carla J. Cohen, Carla J. Cohen, Amity R. Roberts, Paul B. Wordsworth, Paul B. Wordsworth, Paul B. Wordsworth, Tony J. Kenna, Tony J. Kenna   +11 more
doaj   +1 more source

Identification of a myometrial molecular profile for dystocic labor

BMC Pregnancy and Childbirth, 2011
Background The most common indication for cesarean section (CS) in nulliparous women is dystocia secondary to ineffective myometrial contractility. The aim of this study was to identify a molecular profile in myometrium associated with dystocic labor ...
O'Connor Darran P, Rexhepaj Elton, McGee Sharon F, Brennan Donal J, Robson Michael, O'Herlihy Colm   +5 more
doaj   +1 more source

Epistatic interaction between ERAP2 and HLA modulates HIV-1 adaptation and disease outcome in an Australian population.

PLoS Pathogens
A strong genetic predictor of outcome following untreated HIV-1 infection is the carriage of specific alleles of human leukocyte antigens (HLAs) that present viral epitopes to T cells. Residual variation in outcome measures may be attributed, in part, to
Marwah Al-Kaabi, Pooja Deshpande, Martin Firth, Rebecca Pavlos, Abha Chopra, Hamed Basiri, Jennifer Currenti, Eric Alves, Spyros Kalams, Jacques Fellay, Elizabeth Phillips, Simon Mallal, Mina John, Silvana Gaudieri   +13 more
doaj   +1 more source

Behçet’s disease risk association fine-mapped on the IL23R–IL12RB2 intergenic region in Koreans

Arthritis Research & Therapy, 2017
Background Behçet’s disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R–IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide ...
Eun Ha Kang, Sewon Kim, Min Young Park, Ji Yong Choi, In Ah Choi, Min Jung Kim, You-Jung Ha, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Changwon Kang, Yeong Wook Song   +11 more
doaj   +1 more source

THE UNCHARTED ROLE OF ERAP2 IN AGING: A BIOINFORMATICS PERSPECTIVE

Abstract Background Aging is associated with significant changes in the immune system, leading to increased susceptibility to infections, reduced vaccine efficacy, and a higher risk of autoimmune diseases.
openaire   +1 more source

New aspects of spondyloarthritis pathogenesis. Part I. Genetic factors and role of HLA-B27 molecules

Rheumatology, 2014
Recent data verify understanding of spondyloarthritis (SpA) pathogenesis by showing that there is the overlap between traditionally classified subtypes in terms of genetic background (HLA-B27 alleles, variants of IL-23R, ERAP1 and ERAP2 genes), which is ...
Ewa Kontny
doaj   +1 more source

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

Frontiers in Immunology, 2017
Antigenic peptides presented by the major histocompatibility complex class I (MHC-I) molecules for recognition by cytotoxic T-lymphocytes are processed by members of the oxytocinase sub-family of M1 aminopeptidases ERAP1, ERAP2, and IRAP.
Athanasios Papakyriakou, Athanasios Papakyriakou, Efstratios Stratikos   +2 more
doaj   +1 more source