Results 71 to 80 of about 2,874 (176)

Clinical and Genetic Associations in Cephalosporin‐Induced Liver Injury: Insights From the Drug‐Induced Liver Injury Network

Alimentary Pharmacology &Therapeutics, Volume 62, Issue 10, Page 1012-1022, November 2025.
Cephalosporin‐induced liver injury usually presents as a self‐limited, mixed, or cholestatic hepatitis without hypersensitivity features, typically developing 1 to 4 weeks after treatment. With cefazolin, it often occurs after a single parenteral dose. A strong genetic association has been found with HLA‐A*02:01, with more severe liver injury at onset.
Raj Vuppalanchi, Yi‐Ju Li, Don C. Rockey, Dina Halegoua‐DeMarzio, Robert J. Fontana, Herbert L. Bonkovsky, Christopher Koh, Joseph Odin, Huiman Barnhart, Jay H. Hoofnagle, Drug‐Induced Liver Injury Network (DILIN)   +10 more
wiley   +1 more source

From expression pattern to genetic association in asthma and asthma-related phenotypes [PDF]

, 2012
Background : Asthma is a complex disease characterized by hyperresponsiveness, obstruction and inflammation of the airways. To date, several studies using different approaches as candidate genes approach, genome wide association studies, linkage ...
Bordeleau, Martine, Laprise, Catherine, Laviolette, Michel, Vaillancourt, Vanessa T   +3 more
core   +2 more sources

Peeling Skin, Leukonychia, Acral Punctate Keratoses, Cheilitis and Knuckle Pads (PLACK) Syndrome: An Updated Review of Cases and Identification of a Recurrent CAST Variant in Two Patients

Pediatric Dermatology, Volume 42, Issue 6, Page 1239-1247, November/December 2025.
ABSTRACT Peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK) syndrome (OMIM616295) is an exceptionally rare autosomal recessive genodermatosis caused by loss‐of‐function pathogenic variants in the CAST gene, encoding calpastatin.
Fiona Haxho, Richard M. Haber, Janan Mohamad, Ofer Sarig, Eli Sprecher, Renée Perrier, Dana Boctor, Michele Ramien   +7 more
wiley   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

TAPBPR: a new player in the MHC class I presentation pathway. [PDF]

, 2015
In order to provide specificity for T cell responses against pathogens and tumours, major histocompatibility complex (MHC) class I molecules present high-affinity peptides at the cell surface to T cells.
Abe, Apcher, Apcher, Bakke, Basha, Bevan, Boyle, Boyle, Brewerton, Brocke, Burton, Chen, Chen, Cho, D'Alessio, Dalchau, Degen, Del Val, Denzin, Denzin, Deverson, Dick, Dong, Du Pasquier, Eisenlohr, Ellgaard, Elliott, Evans, Evnouchidou, Frickel, Gao, Garbi, Garstka, Garstka, Goulder, Grandea, Grandea, Greenwood, Hall, Ham, Hateren, Hermann, Howarth, Joffre, Kanaseki, Kienast, Kleijmeer, Korfali, Kozik, Kunte, Ladasky, Lampen, Landis, Leach, Lehner, Lewis, Lotteau, Marguet, Maric, Neisig, Oliveira, Ortmann, Paquet, Park, Park, Park, Paulsson, Peaper, Peaper, Peh, Petersen, Porter, Purcell, Reeves, Riberdy, Rizvi, Roche, Roche, Romagnoli, Rufer, Sadasivan, Salter, Saric, Saunders, Schlosstein, Serwold, Spies, Spies, Spies, Spiliotis, Starck, Sugita, Suh, Teng, Trowsdale, Turnquist, Turnquist, Vigna, Wearsch, Wearsch, Wei, Williams, Yewdell, York, Zernich, Zhang, Zhang   +106 more
core   +2 more sources

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing [PDF]

Scientific Reports, 2016
Abstract The processing of MHC class I antigenic precursor peptides by the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 is an important event in the cell biology of antigen presentation. To date, the molecular context by which the ERAP enzymes trim precursor peptides, and how ERAPs shape peptide repertoires, remain open ...
Hanna Chen, Lenong Li, Mirjana Weimershaus, Irini Evnouchidou, Peter van Endert, Marlene Bouvier   +5 more
openaire   +2 more sources

Genetic adaptation of the antibacterial human innate immunity network [PDF]

, 2011
[Background] Pathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions.
Aura Muntasell, Ferran Casals, Francesc Calafell, Hafid Laayouni, Jaume Bertranpetit, Ludovica Montanucci, Martin Sikora, Mihai G Netea, Philip Awadalla, Ross Lazarus   +9 more
core   +3 more sources

Analysis of Hyperexpanded T Cell Clones in SARS‐CoV‐2 Vaccine‐Associated Liver Injury by Spatial Proteomics and Transcriptomics

Liver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background and Aims SARS‐CoV‐2 vaccine‐associated liver injury (SVALI) is a rare event and its pathophysiology remains unclear. Previous studies have found an oligoclonal CD8+ T cell infiltrate and SARS‐CoV‐2 spike antigen‐specific T cells in the liver of patients with SVALI. Therefore, we aimed to characterise the immune infiltrate in a liver
Sarp Uzun, Asmita Pant, Ewelina Bartoszek, Paul Gueguen, Stefan Frei, Hélène Heusler, Ilaria Arborelli, Carl Philipp Zinner, Neşe Karadağ Soylu, Benedetta Terziroli Beretta‐Piccoli, Cumali Efe, Matthias S. Matter   +11 more
wiley   +1 more source

Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women

International Journal of Genomics, 2018
Recent studies have demonstrated the importance of endoplasmic reticulum aminopeptidase (ERAP) in blood pressure (BP) homeostasis. To date, no large prospective, genetic–epidemiological data are available on genetic variation within ERAP and hypertension
Robert Y. L. Zee, Alicia Rivera, Yaritza Inostroza, Paul M. Ridker, Daniel I. Chasman, Jose R. Romero   +5 more
doaj   +1 more source