Results 81 to 90 of about 2,874 (176)
Oxidative Stress in Antigen Processing and Presentation
MedComm – Oncology, Volume 4, Issue 2, June 2025.Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang +9 more
wiley +1 more source
The FASEB Journal, Volume 39, Issue 4, 28 February 2025.Graphical representation of the study workflow. iPSC‐derived human cortical organoids (HCOs) at Day 40, were in vitro infected by SARS‐CoV‐2 or exposed to the Spike protein and viral infection/replication was assessed by a multidisciplinary approach using RT‐qPCR, TCID50, and immunofluorescence.
Gioia Cappelletti +11 more
wiley +1 more source
Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis
Life, 2021 Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk ...
Wanda Niepiekło-Miniewska +6 more
doaj +1 more source
Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome [PDF]
, 2018 Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes.
Altmäe, Signe +11 more
core +1 more source
Genetic and Genomic Approaches to the Study of Drug‐Induced Liver Injury
Liver International, Volume 45, Issue 1, January 2025.ABSTRACT Idiosyncratic hepatotoxicity induced by prescribed drugs has been known since the early 20th century. Identifying risk factors, including genetic factors, that trigger this drug‐induced liver injury (DILI) has been an important priority for many years, both to prevent drugs that cause liver injury being licensed and as a potential means of ...
Ann K. Daly
wiley +1 more source
Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease [PDF]
, 2015 BACKGROUND: Machado-Joseph disease (or spinocerebellar ataxia type 3) is a late-onset polyglutamine neurodegenerative disorder caused by a mutation in the ATXN3 gene, which encodes for the ubiquitously expressed protein ataxin-3.
Bettencourt, Bruno +13 more
core +2 more sources
Transcriptomic Profiling of Dental Tissue‐Derived Mesenchymal Stem Cells
Stem Cells International, Volume 2025, Issue 1, 2025.The aim of this study was to compare whole‐genome gene expressions of periodontal ligament (PDL) and pulp (P) mesenchymal stem cells (MSCs) isolated from third molar (m), premolar (p), and deciduous (dec) teeth. Total RNAs were isolated and used for cRNA synthesis. Human Expression Hybridization Assay was used for 47,000 probes.
Sema S. Hakki +5 more
wiley +1 more source
Frontiers in Oncology, 2014 Endoplasmic Reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are key components on the pathway that generates antigenic epitopes for presentation to cytotoxic T-lymphocytes (CTLs).
Efstratios eStratikos +3 more
doaj +1 more source
The global effect of follicle-stimulating hormone and tumour necrosis factor α on gene expression in cultured bovine ovarian granulosa cells [PDF]
, 2014 Background Oocytes mature in ovarian follicles surrounded by granulosa cells. During follicle growth, granulosa cells replicate and secrete hormones, particularly steroids close to ovulation.
Glister, Claire +4 more
core +2 more sources
Apprêtement des antigènes présentés par les molécules de classe I du CMH [PDF]
, 2006 Les défenses immunitaires de l’organisme vis-à-vis des agents pathogènes et des cellules malignes reposent en grande partie sur la surveillance par les lymphocytes T cytotoxiques.
Endert, Peter van
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