Results 81 to 90 of about 1,626 (143)

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Identification of macrophage-related genes correlated with prognosis and immunotherapy efficacy in non-small cell lung cancer

Heliyon
Background: Malignant tumours, particularly non-small cell lung cancer (NSCLC), pose a significant threat to human health due to their prevalence and lethality.
Shaodi Wen, Renrui Zou, Xiaoyue Du, Rongtian Pan, Rutao Li, Jingwei Xia, Cong Xu, Ruotong Wang, Feng Jiang, Guoren Zhou, Jifeng Feng, Miaolin Zhu, Xin Wang, Bo Shen   +13 more
doaj   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

The Role of Aminopeptidase ERAP1 in Human Pathology—A Review

Current Issues in Molecular Biology
Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic
Laura Țiburcă, Dana Carmen Zaha, Maria Claudia Jurca, Emilia Severin, Aurora Jurca, Alexandru Daniel Jurca   +5 more
doaj   +1 more source

Erap2 silencing by mutation of the NOD2 leucine-rich region.

Antigen presentation was implicated by selective control of ERAP2 based on location of NOD2 mutation.  Erap2 was not significantly affected by presence of single L1007P variants. The data demonstrate specific dysregulation of the antigen presentation pathway by homozygous NOD2 variation (SNP13, L1007fsinsC, L1007P_) that confers more significant risk ...
openaire   +1 more source

Targeting ERAPs in autoimmune uveitis: The function and regulation of ERAP2 in birdshot uveitis

, 2023
In this thesis, we aim to better understand how the genetic predisposition of ERAPs and MHC-I contributes to autoimmunity. These endoplasmic reticulum aminopeptidases (ERAPs) are involved in trimming peptides before these peptides are loaded on MHC-I. Using birdshot uveitis (BU) as a prototypic MHC-I associated autoimmunity model, we examine how ERAP2 ...
Venema, Wouter Jozef, Boer, J.H. de, Kuiper, J.J.W., Ossewaarde-van Norel, J.   +3 more
openaire   +1 more source

Moonlighting ERAP Aminopeptidases in Cancer: Beyond Antigen Processing. [PDF]

Cells
Gragera P, Scaldaferri V, Fruci D.
europepmc   +1 more source

Functional and computational interrogation of juvenile idiopathic arthritis risk loci in CD4+ T cells. [PDF]

HGG Adv
Jiang K, Haley EK, Barshad G, He A, Rogic A, Rice E, Sudman M, Thompson SD, Murphy DA, Fu Y, Ponder L, Munoz MD, Kolachala P, Prahalad S, Gaffney PM, Danko CG, Jarvis JN.   +16 more
europepmc   +1 more source

Leveraging expression quantitative trait loci information in single-cell resolution to identify cell-specific genes for gestational diabetes. [PDF]

PLoS One
Zhu W, Wu X, Hu R.
europepmc   +1 more source

Patient-matched transcriptomics of in vivo and in vitro colonic epithelium substantiate organoids as a translational model for ulcerative colitis. [PDF]

Sci Rep
Walaas GAE, Sridhar A, Kuraas LF, Sæterstad S, Schioldborg AY, Van Beelen Granlund A, Sandvik AK, Østvik AE, Bakke I, Bruland T.   +9 more
europepmc   +1 more source