Results 101 to 110 of about 2,874 (176)

An Overview on ERAP Roles in Infectious Diseases

Cells, 2020
Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are crucial enzymes shaping the major histocompatibility complex I (MHC I) immunopeptidome. In the ER, these enzymes cooperate in trimming the N-terminal residues from precursors peptides,
Irma Saulle, Chiara Vicentini, Mario Clerici, Mara Biasin   +3 more
doaj   +1 more source

Proteomic exploration of potential blood biomarkers in haemophilic arthropathy

Health Science Reports, Volume 7, Issue 9, September 2024.
Abstract Background and Aims The pathophysiology of haemophilic arthropathy (HA) is complex and largely undefined. Proteomic analyses provide insights into the intricate mechanisms of the HA. Our study aimed to identify differentially expressed proteins in relation to the severity of HA, explore their pathophysiological roles, and evaluate their ...
Nataša Kalebota, Ruđer Novak, Stela Hrkač, Porin Perić, Grgur Salai, Marko Močibob, Marija Pranjić, Zbyněk Zdráhal, Václav Pustka, Nadica Laktašić Žerjavić, Milan Milošević, Marijo Vodanović, Silva Zupančić Šalek, Lovorka Grgurević   +13 more
wiley   +1 more source

RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?

Frontiers in Immunology, 2019
Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and ...
Matteo Vecellio, Matteo Vecellio, Matteo Vecellio, Carla J. Cohen, Carla J. Cohen, Carla J. Cohen, Amity R. Roberts, Paul B. Wordsworth, Paul B. Wordsworth, Paul B. Wordsworth, Tony J. Kenna, Tony J. Kenna   +11 more
doaj   +1 more source

Stabilization of the open conformation οf insulin‐regulated aminopeptidase by a novel substrate‐selective small‐molecule inhibitor

Protein Science, Volume 33, Issue 9, September 2024.
Abstract Insulin‐regulated aminopeptidase (IRAP) is an enzyme with important biological functions and the target of drug‐discovery efforts. We combined in silico screening with a medicinal chemistry optimization campaign to discover a nanomolar inhibitor of IRAP based on a pyrazolylpyrimidine scaffold.
Anastasia Mpakali, Galateia Georgaki, Alberto Buson, Alison D. Findlay, Jonathan S. Foot, Francois‐Xavier Mauvais, Peter van Endert, Petros Giastas, Dieter W. Hamprecht, Efstratios Stratikos   +9 more
wiley   +1 more source

Charity Auctions for the Happy Few [PDF]

Recent literature has shown that all-pay auctions raise more money for charity than winner-pay auctions. We demonstrate that the first-price and second-price winner-pay auctions outperform the first-price and second-price all-pay auction when bidders are
Olivier Bos
core  

Association Study of Common Genetic Variants and HIV- 1 Acquisition in 6,300 Infected Cases and 7,200 Controls [PDF]

, 2013
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have
Bakker, De, Buchbinder, Susan, Carrington, Mary, Cossarizza, Andrea, Coulonges, Cédric, Dalmau, Judith, De Luca, Andrea, Deeks, Steven G., Delaneau, Olivier, Fellay, Jacques, Goedert, James J., Goldstein, David B., Haas, David, Herbeck, Joshua T., Kathiresan, Sekar, Kirk, Gregory D., Lambotte, Olivier, Luo, Ma, Mallal, Simon, Martinez-Picado, Javier, Mclaren, Paul J., Meyer, Laurence, Miro, José M., Mullins, James I., O'Brien, Stephen J., Obel, Niels, Paul, I. W., Pereyra, Florencia, Plummer, Francis A., Poli, Guido, Qi, Ying, Ripke, Stephan, Rucart, Pierre, Sandhu, Manj S., Schuitemaker, Hanneke, Shea, Patrick R., Telenti, Amalio, Theodorou, Ioannis, Van Den Berg, Leonard, Van Manen, Daniëlle, Vannberg, Fredrik, Veldink, Jan, Walker, Bruce D., Weintrob, Amy, Winkler, Cheryl A., Wolinsky, Steven, Zagury, Jean-François   +46 more
core   +7 more sources

Identification of a myometrial molecular profile for dystocic labor

BMC Pregnancy and Childbirth, 2011
Background The most common indication for cesarean section (CS) in nulliparous women is dystocia secondary to ineffective myometrial contractility. The aim of this study was to identify a molecular profile in myometrium associated with dystocic labor ...
O'Connor Darran P, Rexhepaj Elton, McGee Sharon F, Brennan Donal J, Robson Michael, O'Herlihy Colm   +5 more
doaj   +1 more source

Charity auctions for the happy few [PDF]

, 2008
Recent literature has shown that all-pay auctions raise more money for charity than winner-pay auctions. We demonstrate that the first and second-price winner-pay auctions generate higher revenue than first-price all-pay auctions when bidders are ...
Bos, Olivier
core  

Chitinase 3‐like 1 is neurotoxic in multiple sclerosis patient‐derived cortical neurons

Clinical and Translational Medicine, Volume 14, Issue 12, December 2024.
Rucsanda Pinteac, Jordi Soriano, Clara Matute‐Blanch, José M Lizcano, Anna Duarri, Sunny Malhotra, Herena Eixarch, Gloria López Comellas, Xavier Montalban, Manuel Comabella   +9 more
wiley   +1 more source

Μελέτη της εξειδίκευσης και του μηχανισμού λειτουργίας των αμινοπεπτιδασών ERAP1, ERAP2 και IRAP [PDF]

, 2021
Οι αμινοπεπτιδάσες ERAP1, ERAP2 και IRAP αποτελούν σημαντικά συστατικά του επίκτητου ανοσοποιητικού συστήματος του ανθρώπου, συμμετέχοντας ενεργά στους μηχανισμούς αντιγονοπαρουσίασης. Λειτουργία τους είναι η παραγωγή ώριμων αντιγονικών επιτόπων, κατάλληλων για πρόσδεση σε μόρια τάξης I του MHC.
openaire   +1 more source