Results 111 to 120 of about 2,874 (176)

Behçet’s disease risk association fine-mapped on the IL23R–IL12RB2 intergenic region in Koreans

Arthritis Research & Therapy, 2017
Background Behçet’s disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R–IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide ...
Eun Ha Kang, Sewon Kim, Min Young Park, Ji Yong Choi, In Ah Choi, Min Jung Kim, You-Jung Ha, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Changwon Kang, Yeong Wook Song   +11 more
doaj   +1 more source

New aspects of spondyloarthritis pathogenesis. Part I. Genetic factors and role of HLA-B27 molecules

Rheumatology, 2014
Recent data verify understanding of spondyloarthritis (SpA) pathogenesis by showing that there is the overlap between traditionally classified subtypes in terms of genetic background (HLA-B27 alleles, variants of IL-23R, ERAP1 and ERAP2 genes), which is ...
Ewa Kontny
doaj   +1 more source

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

Frontiers in Immunology, 2017
Antigenic peptides presented by the major histocompatibility complex class I (MHC-I) molecules for recognition by cytotoxic T-lymphocytes are processed by members of the oxytocinase sub-family of M1 aminopeptidases ERAP1, ERAP2, and IRAP.
Athanasios Papakyriakou, Athanasios Papakyriakou, Efstratios Stratikos   +2 more
doaj   +1 more source

Identification of macrophage-related genes correlated with prognosis and immunotherapy efficacy in non-small cell lung cancer

Heliyon
Background: Malignant tumours, particularly non-small cell lung cancer (NSCLC), pose a significant threat to human health due to their prevalence and lethality.
Shaodi Wen, Renrui Zou, Xiaoyue Du, Rongtian Pan, Rutao Li, Jingwei Xia, Cong Xu, Ruotong Wang, Feng Jiang, Guoren Zhou, Jifeng Feng, Miaolin Zhu, Xin Wang, Bo Shen   +13 more
doaj   +1 more source

Targeting inflammatory pathways in axial spondyloarthritis. [PDF]

, 2019
The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have proven successful in suppressing many of the ...
Furst, Daniel E, Louie, James S
core  

THE UNCHARTED ROLE OF ERAP2 IN AGING: A BIOINFORMATICS PERSPECTIVE

AbstractBackgroundAging is associated with significant changes in the immune system, leading to increased susceptibility to infections, reduced vaccine efficacy, and a higher risk of autoimmune diseases. However, the molecular mechanisms driving these immunological alterations remain incompletely understood.
openaire   +1 more source

UEG Week 2024 Poster Presentations

United European Gastroenterology Journal, Volume 12, Issue S8, Page 665-1360, October 2024.
wiley   +1 more source

Science [PDF]

Little is known about how human genetic variation affects the responses to environmental stimuli in the context of complex diseases. Experimental and computational approaches were applied to determine the effects of genetic variation on the induction of ...

core  

The Impact of ERAP1 and ERAP2 Haplotype Combinations on Susceptibility and Severity of Birdshot Chorioretinitis. [PDF]

Invest Ophthalmol Vis Sci
Loeliger J, Gelfman S, Stahl EA, Moscati A, Bai X, Monnet D, Imikirene L, Kecili S, Tabary T, Cohen J, Brézin AP.   +10 more
europepmc   +1 more source

Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease. [PDF]

Mamm Genome
Win LK, Cheng G, Ashton JJ, Kadhim AZ, Green Z, Beattie RM, Ennis S.   +6 more
europepmc   +1 more source