Insights into human adaptation from ancient DNA. [PDF]
Nat GenetMemarMoshrefi D, Johnson OL, Huber CD.
europepmc +1 more source
Cannabinoid Receptor Type 2 Agonist JWH-133 Stimulates Antiviral Factors and Decreases Proviral, Inflammatory, and Neurotoxic Proteins in HIV-Infected Macrophage Secretome. [PDF]
Int J Mol SciRosario-Rodríguez LJ +6 more
europepmc +1 more source
A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation [PDF]
International Journal of Molecular Sciences, 2022 The M1 zinc metalloproteases ERAP1, ERAP2, and IRAP play a role in HLA-I antigen presentation by refining the peptidome either in the ER (ERAP1 and ERAP2) or in the endosomes (IRAP). They have also been entrusted with other, although less defined, functions such as the regulation of the angiotensin system and blood pressure.
Alessandro Paiardini +2 more
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Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis
Angewandte Chemie - International Edition, 2022 AbstractEndoplasmic reticulum aminopeptidase 2 (ERAP2) is a key enzyme involved in the trimming of antigenic peptides presented by Major Histocompatibility Complex class I. It is a target of growing interest for the treatment of autoimmune diseases and in cancer immunotherapy.
Julie Dumont +2 more
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ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients
Human Immunology, 2019The objective of this case-control study was to evaluate the role of four single-nucleotide polymorphisms in the ERAP1 (rs2287987, rs30187, rs27044) and ERAP2 (rs2248374) genes and their haplotypes in predicting the risk for ankylosing spondylitis (AS) on a well-defined Polish population.
Andrzej, Wiśniewski +7 more
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Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations
Human Immunology, 2019The endoplasmic reticulum aminopeptidases (ERAPs), ERAP1 and ERAP2, makes a role in shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I-mediated antigen presentation and educating the immune system to differentiate between self-derived and foreign antigens.
Yufeng Yao +3 more
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ERAP1/ERAP2 And RUNX3 Polymorphisms Are Not Associated With Ankylosing Spondylitis Susceptibility in Chinese Han [PDF]
Clinical and Experimental Immunology, 2018 Summary Previous studies show that endoplasmic reticulum-associated aminopeptidase (ERAP1/ERAP2) and runt-related transcription factor 3 (RUNX3) gene polymorphisms are associated with AS (ankylosing spondylitis) in European Caucasians. However, contradictory results were reported in different Asian populations.
Peizeng Yang, A Kijlstra
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The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective
Molecular Immunology, 2020Autoimmunity and cancer affect millions worldwide and both, in principal, result from dysregulated immune responses. There are many well-known molecules involved in immunological process playing as a double-edged sword, by which associating autoimmune diseases and cancer.
Farhad, Babaie +9 more
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Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease
Human Immunology, 2019Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) is an intracellular enzyme localized in the ER that has been shown to play roles in the generation of peptides that serve as ligands for MHC class I (MHC-1) molecules. Although ERAP2 has been primarily described as an accessory and complementary enzyme to the homologous ERAP1, several lines of evidence ...
José A López, de Castro +1 more
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DISSECTING ERAP2 ROLE IN HIV-1 INFECTION
2019Introduzione: La risposta immunitaria contro HIV composita e complessa: entrano in gioco molti fattori appartenenti sia al virus che all?ospite e le variabili interindividuali non sono trascurabili e agiscono su vari livelli. Molti studi sono stati condotti per valutare l?influenza che questi diversi fattori possono esercitare sull?infezione da HIV-1
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