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EpCAM associates with endoplasmic reticulum aminopeptidase 2 (ERAP2) in breast cancer cells
Biochemical and Biophysical Research Communications, 2013Epithelial cell adhesion molecule (EpCAM) is an epithelial and cancer cell "marker" and there is a cumulative and growing evidence of its signaling role. Its importance has been recognized as part of the breast cancer stem cell phenotype, the tumorigenic breast cancer stem cell is EpCAM(+).
Salah-Eldin, Gadalla +6 more
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Variation in ERAP2 Has Opposing Effects on Severe Respiratory Infection and Autoimmune Disease
American Journal of Human Genetics, 2023John Kenneth Baillie +2 more
exaly
Function of ERAP2 (endoplasmic reticulum aminopeptidase 2) in cancer immunity
Journal of Reproductive Immunology, 2021Nobuki Hayashi +10 more
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Interpreting ERAP2 as an Ageing‐Derived Biomarker for Premature Ovarian Insufficiency
BJOG: An International Journal of Obstetrics & GynaecologyXiaowen Feng, Yidan Jin, Ruijin Wu
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Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1, ERAP2), along with Insulin-Regulated Aminopeptidase (IRAP), play key roles in antigen processing by trimming precursor peptides for major histocompatibility complex (MHC) class I presentation, thereby contributing to adaptive immune regulation.
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