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A Gene-Based Association Method for Mapping Traits Using Reference Transcriptome Data [PDF]
, 2015 Genome-wide association studies (GWAS) have identified thousands of variants robustly associated with complex traits. However, the biological mechanisms underlying these associations are, in general, not well understood.
Aquino-Michaels, Keston +11 more
core +3 more sources
IET Systems Biology, Volume 18, Issue 6, Page 271-284, December 2024.Differential expression of genes between AD patients and the normal population (a) Basic information of GSE5281 dataset. AD patient samples were labelled with green, while control group samples were labelled with purple. (b) Uniform manifold approximation and projection(UMAP) of differentially expressed gene (DEG) in GSE5281. (c) Expression density map
Shaoqiang Wang, Yifan Wang
wiley +1 more source
Transcriptome profiling of IL-17A preactivated mesenchymal stem cells: a comparative study to unmodified and IFN-gamma modified mesenchymal stem cells [PDF]
, 2017 Published 15 February 2017Human mesenchymal stem cells pretreatment with IL-17A (MSC-17) potently enhances T cell immunosuppression but not their immunogenicity, in addition to avidly promoting the induction of suppressive regulatory T cells.
Coates, P.T. +4 more
core +4 more sources
Autophagy‐dependent regulation of MHC‐I molecule presentation
Journal of Cellular Biochemistry, Volume 125, Issue 11, November 2024.Abstract The major histocompatibility complex (MHC) class I molecules present peptide antigens to MHC class I‐restricted CD8+ T lymphocytes to elicit an effective immune response. The conventional antigen‐processing pathway for MHC‐I presentation depends on proteasome‐mediated peptide generation and peptide loading in the endoplasmic reticulum by ...
Uxia Gestal‐Mato, Lina Herhaus
wiley +1 more source
DISSECTING ERAP2 ROLE IN HIV-1 INFECTION
, 2019 Background: Immune response during HIV-1 infection and replication is quite complex because many viral and host factors, beyond individual variables, are involved at different levels. Many efforts have been made to evaluate the influence of these factors on HIV-1 infection and disease progression mainly focusing on the identification of genetic ...
openaire +1 more source
The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis [PDF]
Clinical and Experimental Immunology, 2017 SummaryThe human leukocyte antigen class I gene HLA-B27 is the strongest risk factor for ankylosing spondylitis (AS), a chronic inflammatory arthritic disorder. More recently, the Endoplasmic Reticulum Aminopeptidase (ERAP) 1 and 2 genes have been identified by genome wide association studies (GWAS) as additional susceptibility factors.
VITULANO, CAROLINA +4 more
openaire +2 more sources
Molecular Genetics &Genomic Medicine, Volume 12, Issue 11, November 2024.ERAP1 gene mutation may be associated with psoriasis vulgaris and HLA‐C0602 in Han nationality in Inner Mongolia. A risk haplotype of four‐nonsynonymous mutation (E730/K528/R127/E56) is associated with PsV. ABSTRACT Background This study aimed to investigate the association between genetic variants of ERAP1 (OMIM: 606832) and psoriasis vulgaris (PsV ...
Xin Li +10 more
wiley +1 more source
Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency [PDF]
ACS Medicinal Chemistry Letters, 2017 Endoplasmic reticulum aminopeptidase 2 assists with the generation of antigenic peptides for presentation onto Major Histocompatibility Class I molecules in humans. Recent evidence has suggested that the activity of ERAP2 may contribute to the generation of autoimmunity, thus making ERAP2 a possible pharmacological target for the regulation of adaptive
Anastasia Mpakali +10 more
openaire +3 more sources
CNS Neuroscience &Therapeutics, Volume 30, Issue 11, November 2024.Because of CSF biomarkers identified by neuroimaging techniques in the middle or late stages of AD, blood is considered as the novel biomarker resource for the early diagnosis of AD. The accurate alternations in blood could predict AD. This paper discusses potential blood‐based biomarkers identified by proteomics and metabolomics and future research ...
Yun Dong +4 more
wiley +1 more source
Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells [PDF]
, 2015 Additional file 2: Table S1. Gene ontology analysis result. Table S2. Esrrb expression with DY131 treatment (control vs. Esrrb + DY131)
Dennis B. Lubahn +3 more
core +3 more sources