Results 61 to 70 of about 2,874 (176)

ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancer

Aging, 2022
Abstract Background Pancreatic cancer is one of the most malignant tumors, with rapid metastasis, high mortality rate, and difficult early screening. Currently, gemcitabine is a first-line drug for pancreatic cancer patients, but its clinical effect is limited due to drug resistance.
Yu, Pian, Luo, Shifu, Cai, Jiaxin, Li, Jie, Peng, Cong   +4 more
openaire   +2 more sources

Computational Insights on the Impact of Allotypic Variation and Dimerization on Erap1 and Erap2 Structures Running Title: Structural Analysis of Erap1 and Erap2 Allotype Dimers

, 2023
Abstract Ankylosing Spondylitis is an autoimmune disease leading to inflammation in the joints and ligaments of the spine. ERAP1 is a major risk factor for AS and ERAP1 mutations may result in structural changes that alter the trimming efficiency, thereby altering the immune response. The underlying structural mechanisms of AS pathogenesis have
Yunus Emre Dilek, İrem Kara, Sena Kıvrak, Şeyma Çolakoğlu Özkaya, Can Erzik, Kerem Yiğit Abacar, Mehmet Pamir Atagündüz, Gunseli Bayram Akcapinar   +7 more
openaire   +1 more source

The potential impact of the fetal genotype on maternal blood pressure during pregnancy. [PDF]

, 2014
The heritability of pregnancy-induced hypertension (encompassing both gestational hypertension and preeclampsia) is around 0.47, suggesting that there is a genetic component to its development.
Beardsall, Kathryn, Dunger, David B, Petry, Clive J   +2 more
core   +1 more source

Correction to: The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response [PDF]

Journal of Translational Medicine
Siri Sæterstad, Ann Elisabeth Østvik, Marianne Doré Hansen, Torunn Bruland, Atle van Beelen Granlund   +4 more
doaj   +2 more sources

Studies of stem cell and adhesion proteins in breast cancer [PDF]

, 2014
Breast cancer is the commonest cancer and second leading cause of cancer death in women. It has been shown that breast cancer tumorigenic/stem cell like cells are CD24-/low CD44+EpCAM+.
Gadalla, Salah-Eldin
core   +1 more source

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis [PDF]

Human Molecular Genetics, 2018
AbstractBirdshot Uveitis (Birdshot) is a rare eye condition that affects HLA-A29-positive individuals and could be considered a prototypic member of the recently proposed “MHC-I-opathy” family. Genetic studies have pinpointed the ERAP1 and ERAP2 genes as shared associations across MHC-I-opathies, which suggests ERAP dysfunction may be a root cause for ...
Kuiper, Jonas J.W., van Setten, Jessica, Devall, Matthew, Cretu-Stancu, Mircea, Hiddingh, Sanne, Ophoff, Roel A., Missotten, Tom O.A.R., van Velthoven, Mirjam, Den Hollander, Anneke I, Hoyng, Carel B, James, Edward, Reeves, Emma, Cordero-Coma, Miguel, Fonollosa, Alejandro, Adán, Alfredo, Martín, Javier, Koeleman, Bobby P.C., de Boer, Joke H., Pulit, Sara L., Márquez, Ana, Radstake, Timothy R. D. J.   +20 more
openaire   +8 more sources

Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design [PDF]

, 2014
The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells.
Boucau, Julie, Dinter, Jens, Kourjian, Georgio, Le Gall, Sylvie, Rucevic, Marijana   +4 more
core   +2 more sources

ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes

Immunology, Volume 177, Issue 2, Page 398-412, February 2026.
ERAP1 is an intracellular aminopeptidase that edits antigenic peptides to be presented by MHC class I molecules and is found in distinct functional allotypes in individuals. To investigate how different disease‐associated ERAP1 allotypes affect the cellular immunopeptidome, we generated A375 melanoma cell clones carrying either allotype 2 or allotype ...
Martha Nikopaschou, Martina Samiotaki, Anna Kannavou, Nikolaos V. Angelis, Ourania Tsitsilonis, George Panayotou, Efstratios Stratikos   +6 more
wiley   +1 more source

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy [PDF]

Human Molecular Genetics, 2014
Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune uveitis that can lead to severe visual impairment. Intriguingly, >95% of cases carry the HLA-A29 allele, which defines the strongest documented HLA association for a human disease. We have conducted a genome-wide association study in 96 Dutch and 27 Spanish cases, and 398 unrelated Dutch ...
Kuiper, J.J., van Setten, J., Ripke, S., Van, T.S.R., Mulder, F., Missotten, T., Baarsma, G.S., Francioli, L.C., Pulit, S.L., de Kovel, C.G.F., ten Dam-van Loon, N., den Hollander, A.I., den Hollander, A.I., Huis in het Veld, P., Hoyng, C.B., Cordero-Coma, M., Martin, J., Llorenc, V., Arya, B., Thomas, D, Bakker, S.C., Ophoff, R.A., Rothova, A., de Bakker, P.I., Mutis, T, Koeleman, B.P.   +25 more
openaire   +8 more sources

The value of cuproptosis-related differential genes in guiding prognosis and immune status in patients with skin cutaneous melanoma

Frontiers in Pharmacology, 2023
Background: Skin cutaneous melanoma (SKCM) is one of the most common cutaneous malignancies, which incidence is increasing. Cuproptosis is a new type of programming cell death recently reported, which may affect the progression of SKCM.Method: The mRNA ...
Yuming Sun, Shaorong Lei, Xiangyue Luo, Chufeng Jiang, Zhexuan Li   +4 more
doaj   +1 more source