Results 61 to 70 of about 1,626 (143)

HLA‐B*44 Alleles and HLA‐DQA1*03:01 as Genetic Risk Factors for Drug‐Induced Liver Injury due to Fluoroquinolones

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Fluoroquinolone exposure can give rise to drug‐induced liver injury. Genetic risk factors for this form of liver injury are poorly understood but some evidence suggests that HLA genes contribute. This study aimed to characterise HLA risk factors for fluoroquinolone‐induced liver injury in a European population. Methods From
Paola Nicoletti, M. Isabel Lucena, Raul J. Andrade, Samreen Zafer, Einar S. Bjornsson, Pär Hallberg, Dominique Larrey, Mariam Molokhia, Mia Wadelius, Guruprasad P. Aithal, Ann K. Daly   +10 more
wiley   +1 more source

Stable β2‐Microglobulin–HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer‐Associated Epitopes

European Journal of Immunology, Volume 56, Issue 5, May 2026.
We investigated differences in peptide repertoire when β2‐microglobulin is fused to the HLA‐I heavy chain. We observed: (1) that immunopeptidomes changed in this condition, (2) an overall increased median IC50 of the entire peptide repertoire, and (3) a reduced presentation of cancer‐specific epitopes with a strong predicted binding affinity for HLA‐I.
Ana Barajas Molina, Yehor Horokhovskyi, Nicole Acuti, Yee Kien Chong, Meghna Phanichkrivalkosil, Sophie Siddons, Hassnae Afrache, Megan Maloney, Wai Tuck Soh, Tom Hofland, Callum Hall, Henning Urlaub, George Kassiotis, Juliane Liepe, Michele Mishto   +14 more
wiley   +1 more source

ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes

Immunology, Volume 177, Issue 2, Page 398-412, February 2026.
ERAP1 is an intracellular aminopeptidase that edits antigenic peptides to be presented by MHC class I molecules and is found in distinct functional allotypes in individuals. To investigate how different disease‐associated ERAP1 allotypes affect the cellular immunopeptidome, we generated A375 melanoma cell clones carrying either allotype 2 or allotype ...
Martha Nikopaschou, Martina Samiotaki, Anna Kannavou, Nikolaos V. Angelis, Ourania Tsitsilonis, George Panayotou, Efstratios Stratikos   +6 more
wiley   +1 more source

Clinical and Genetic Associations in Cephalosporin‐Induced Liver Injury: Insights From the Drug‐Induced Liver Injury Network

Alimentary Pharmacology &Therapeutics, Volume 62, Issue 10, Page 1012-1022, November 2025.
Cephalosporin‐induced liver injury usually presents as a self‐limited, mixed, or cholestatic hepatitis without hypersensitivity features, typically developing 1 to 4 weeks after treatment. With cefazolin, it often occurs after a single parenteral dose. A strong genetic association has been found with HLA‐A*02:01, with more severe liver injury at onset.
Raj Vuppalanchi, Yi‐Ju Li, Don C. Rockey, Dina Halegoua‐DeMarzio, Robert J. Fontana, Herbert L. Bonkovsky, Christopher Koh, Joseph Odin, Huiman Barnhart, Jay H. Hoofnagle, Drug‐Induced Liver Injury Network (DILIN)   +10 more
wiley   +1 more source

A role for naturally occurring alleles of Endoplasmic Reticulum Aminopeptidases in tumor immunity and cancer predisposition

Frontiers in Oncology, 2014
Endoplasmic Reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are key components on the pathway that generates antigenic epitopes for presentation to cytotoxic T-lymphocytes (CTLs).
Efstratios eStratikos, Athanasios eStamogiannos, Efthalia eZervoudi, Doriana eFruci   +3 more
doaj   +1 more source

Peeling Skin, Leukonychia, Acral Punctate Keratoses, Cheilitis and Knuckle Pads (PLACK) Syndrome: An Updated Review of Cases and Identification of a Recurrent CAST Variant in Two Patients

Pediatric Dermatology, Volume 42, Issue 6, Page 1239-1247, November/December 2025.
ABSTRACT Peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK) syndrome (OMIM616295) is an exceptionally rare autosomal recessive genodermatosis caused by loss‐of‐function pathogenic variants in the CAST gene, encoding calpastatin.
Fiona Haxho, Richard M. Haber, Janan Mohamad, Ofer Sarig, Eli Sprecher, Renée Perrier, Dana Boctor, Michele Ramien   +7 more
wiley   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy [PDF]

Human Molecular Genetics, 2014
Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune uveitis that can lead to severe visual impairment. Intriguingly, >95% of cases carry the HLA-A29 allele, which defines the strongest documented HLA association for a human disease. We have conducted a genome-wide association study in 96 Dutch and 27 Spanish cases, and 398 unrelated Dutch ...
Kuiper, J.J., van Setten, J., Ripke, S., Van, T.S.R., Mulder, F., Missotten, T., Baarsma, G.S., Francioli, L.C., Pulit, S.L., de Kovel, C.G.F., ten Dam-van Loon, N., den Hollander, A.I., den Hollander, A.I., Huis in het Veld, P., Hoyng, C.B., Cordero-Coma, M., Martin, J., Llorenc, V., Arya, B., Thomas, D, Bakker, S.C., Ophoff, R.A., Rothova, A., de Bakker, P.I., Mutis, T, Koeleman, B.P.   +25 more
openaire   +8 more sources

Analysis of Hyperexpanded T Cell Clones in SARS‐CoV‐2 Vaccine‐Associated Liver Injury by Spatial Proteomics and Transcriptomics

Liver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background and Aims SARS‐CoV‐2 vaccine‐associated liver injury (SVALI) is a rare event and its pathophysiology remains unclear. Previous studies have found an oligoclonal CD8+ T cell infiltrate and SARS‐CoV‐2 spike antigen‐specific T cells in the liver of patients with SVALI. Therefore, we aimed to characterise the immune infiltrate in a liver
Sarp Uzun, Asmita Pant, Ewelina Bartoszek, Paul Gueguen, Stefan Frei, Hélène Heusler, Ilaria Arborelli, Carl Philipp Zinner, Neşe Karadağ Soylu, Benedetta Terziroli Beretta‐Piccoli, Cumali Efe, Matthias S. Matter   +11 more
wiley   +1 more source