Results 1 to 10 of about 236,762 (343)

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases [PDF]

Neural Regeneration Research
The endoplasmic reticulum, a key cellular organelle, regulates a wide variety of cellular activities. Endoplasmic reticulum autophagy, one of the quality control systems of the endoplasmic reticulum, plays a pivotal role in maintaining endoplasmic ...
Xiu-Yun Zhao, De-En Xu, Ming-Lei Wu, Ji-Chuan Liu, Zi-Ling Shi, Quan-Hong Ma   +5 more
doaj   +5 more sources

Role of endoplasmic reticulum autophagy in acute lung injury. [PDF]

Front Immunol, 2023
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), the prime causes of morbidity and mortality in critically ill patients, are usually treated by general supportive treatments.
Liu S, Fang X, Zhu R, Zhang J, Wang H, Lei J, Wang C, Wang L, Zhan L.   +8 more
europepmc   +5 more sources

FAM134B-mediated endoplasmic reticulum autophagy protects against sepsis myocardial injury in mice. [PDF]

Aging (Albany NY), 2021
Reticulophagy regulator 1 (RETEG1, also known as FAM134B) plays a crucial role in endoplasmic reticulum autophagy. We aimed to explore the effect of FAM134B-mediated endoplasmic reticulum autophagy in sepsis myocardial injury in mice.
Li T, Chen Y, Li Y, Yao Z, Liu W.
europepmc   +2 more sources

Identification and validation of endoplasmic reticulum autophagy-related potential biomarkers in periodontitis. [PDF]

Sci Rep
Periodontitis is a chronic inflammatory disease that mainly occurs in the dental supporting tissues. Endoplasmic reticulum autophagy (ER-phagy) is a new type of selective autophagy. The main function of ER-phagy is to degrade excess ER membranes or toxic
Wang R, Hu J, Sun Q, Guo S, Zhang G, Lu A, Liu S, Yang X, Wang L.   +8 more
europepmc   +2 more sources

Gasdermin D mediates endoplasmic reticulum stress via FAM134B to regulate cardiomyocyte autophagy and apoptosis in doxorubicin-induced cardiotoxicity

Cell Death and Disease, 2022
Cardiomyocyte pyroptosis and apoptosis play a vital role in the pathophysiology of several cardiovascular diseases. Our recent study revealed that gasdermin D (GSDMD) can promote myocardial I/R injury via the caspase-11/GSDMD pathway.
Ya’nan Qu, Rifeng Gao, Xiang Wei, Xiaolei Sun, Kun Yang, Huairui Shi, Yang Gao, Shiyu Hu, Yiwen Wang, Ji’e Yang, Aijun Sun, Feng Zhang, Junbo Ge   +12 more
doaj   +2 more sources

Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis

Frontiers in Pharmacology, 2021
Ulcerative colitis (UC) is a chronic nonspecific inflammation that mainly affects the mucosa and submucosa of the rectum and colon. Numerous studies have shown that endoplasmic reticulum stress (ERS)-induced autophagy plays a vital role in the ...
Dan Qiao, Ziwei Zhang, Yali Zhang, Qian Chen, Yujun Chen, Yingjue Tang, Xiong Sun, Zhipeng Tang, Yancheng Dai   +8 more
doaj   +2 more sources

Research note: duck Tembusu virus non-structural protein 3 induced autophagy through endoplasmic reticulum stress [PDF]

Poultry Science
Duck Tembusu virus (DTMUV) causes severe infectious diseases in poultry. Previous studies have shown that DTMUV induced autophagy and endoplasmic reticulum stress (ERS) in host cells, thereby influencing the virus proliferation.
Shuna Zhang, Ji Fu, Liya Zhu, Yihao Lu, Zhaopeng Zhang, Luna Yu, Jianhua Qiu, Gang Wang, Ning Li   +8 more
doaj   +2 more sources

Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites

Nature Communications, 2020
How autophagy supports tumor cell metabolism is not fully clear. Here, the authors show that autophagy regulates lipid availability to support mitochondrial oxidative metabolism through mitochondria-endoplasmic reticulum contact sites, necessary for cell
Claudie Bosc, Nicolas Broin, Marjorie Fanjul, Estelle Saland, Thomas Farge, Charly Courdy, Aurélie Batut, Rawand Masoud, Clément Larrue, Sarah Skuli, Nicolas Espagnolle, Jean-Christophe Pagès, Alice Carrier, Frédéric Bost, Justine Bertrand-Michel, Jérôme Tamburini, Christian Récher, Sarah Bertoli, Véronique Mansat-De Mas, Stéphane Manenti, Jean-Emmanuel Sarry, Carine Joffre   +21 more
doaj   +2 more sources

GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy. [PDF]

PLoS ONE, 2016
The balance of protein synthesis and proteolysis (i.e. proteostasis) is maintained by a complex regulatory network in which mTOR (mechanistic target of rapamycin serine/threonine kinase) pathway and unfolded protein response are prominent positive and ...
Marianna Holczer, Gábor Bánhegyi, Orsolya Kapuy   +2 more
doaj   +6 more sources

Modulation of endoplasmic reticulum stress–induced insulin resistance by the low-carbohydrate high-fat ketogenic diet [PDF]

Frontiers in Nutrition
This review aimed to investigate the relationship between endoplasmic reticulum (ER) stress, insulin resistance, and the potential mitigating effects of a low-carbohydrate, high-fat diet, Ketogenic diet (LCHF-KD).
Basmah M. Eldakhakhny, Basmah M. Eldakhakhny, Fatma M. Ghoneim, Yousef M. Almoghrabi, Yousef M. Almoghrabi, Ghada Ajabnoor, Ghada Ajabnoor, Faisal Alandejani, Faisal Alandejani, Salwa M. Abo El-Khair, Salma A. Elsamanoudy, Taghreed Shamrani, Moaaz A. Siddiqui, Ayman Z. Elsamanoudy, Ayman Z. Elsamanoudy, Ayman Z. Elsamanoudy   +15 more
doaj   +2 more sources