ER‐phagy: selective autophagy of the endoplasmic reticulum
EMBO reports, 2022 Eukaryotic cells adequately control the mass and functions of organelles in various situations. Autophagy, an intracellular degradation system, largely contributes to this organelle control by degrading the excess or defective portions of organelles. The
Keisuke Mochida, H. Nakatogawa
semanticscholar +3 more sources
Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy
BioMed Research International, 2022 Oxidative stress is an imbalance between free radicals and the antioxidant system causing overgeneration of free radicals (oxygen-containing molecules) ultimately leading to oxidative damage in terms of lipid peroxidation, protein denaturation, and DNA ...
Xiao-qing Liu +5 more
semanticscholar +3 more sources
Frontiers in Pharmacology, 2020 BackgroundSpinal cord ischemia-reperfusion injury (SCIRI) is the main complication after the repair of a complex thoracoabdominal aortic aneurysm.
Chenyu Wu +22 more
doaj +2 more sources
Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis. [PDF]
J Clin Invest, 2016 Conlon DM +9 more
europepmc +2 more sources
CALCOCO1 in the progression of malignant tumors [PDF]
Jichu yixue yu linchuang, 2023 Calcium binding and coiled-coil domain 1 (CALCOCO1) is an autophagy regulatory protein being discovered in recent years, which plays an important role in selective autophagy process.
JIA Nan, WANG Zhilian
doaj +1 more source
RBM10 Regulates Embryonic Trophoblast Injury via Endoplasmic Reticulum Stress
Clinical and Experimental Obstetrics & Gynecology, 2022 Background: Previous studies shown that RNA binding motif proteins (RBM) participate in regulating various physiological processes such as cell autophagy, proliferation, and apoptosis, and are abnormally highly expressed in placental trophoblast cells ...
Xiao Chen +4 more
doaj +1 more source
Endoplasmic reticulum selective autophagy alleviates anthracycline-induced cardiotoxicity
JACC: CardioOncology, 2022 Abstract Unfolded protein response (UPR) plays a critical role for preventing death of cardiomyocytes induced by excessive endoplasmic reticulum (ER) in response to cytotoxicity of anthracycline antineoplastic drugs through mitigating misfoled proteins accumulation in the hearts.
Shun Nakagama +6 more
openaire +2 more sources
Endoplasmic Reticulum Stress Triggers Autophagy [PDF]
Journal of Biological Chemistry, 2006 Eukaryotic cells have evolved strategies to respond to stress conditions. For example, autophagy in yeast is primarily a response to the stress of nutrient limitation. Autophagy is a catabolic process for the degradation and recycling of cytosolic, long lived, or aggregated proteins and excess or defective organelles.
Tomohiro, Yorimitsu +3 more
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Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis. [PDF]
PLoS ONE, 2016 PURPOSE:Butyrate, a short-chain fatty acid derived from dietary fiber, inhibits proliferation and induces cell death in colorectal cancer cells. However, clinical trials have shown mixed results regarding the anti-tumor activities of butyrate.
Jintao Zhang +12 more
doaj +1 more source
Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]
, 2016 Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith +6 more
core +8 more sources