Results 271 to 280 of about 236,762 (343)

UFM1 at the endoplasmic reticulum: linking ER stress, ribosome quality control, and ER-phagy. [PDF]

Essays Biochem
Komatsu M, Mao G.
europepmc   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Pancreatic involvement in <i>EPG5</i>-related disorders. [PDF]

Mol Genet Metab Rep
Famili DT, Elghazali G, Argili E, Saneto RP, Harris M, Gerasimenko O, Gerasimenko J, Fanto M, Dafsari HS, Jungbluth H.   +9 more
europepmc   +1 more source

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection

New Phytologist, EarlyView.
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Pepe Cana‐Quijada, Pablo Morales‐Martínez, Tábata Rosas‐Díaz, Jessica Pérez‐Sancho, Tamara Jiménez‐Góngora, José Antonio Navarro, Rosa Lozano‐Durán, Araceli G. Castillo, Vicente Pallás, Eduardo R. Bejarano   +9 more
wiley   +1 more source

Endoplasmic reticulum stress-mediated programmed cell death in the tumor microenvironment. [PDF]

Cell Death Discov
Chai H, Hu Q, Yao S, Ma S, Su W.
europepmc   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

CD36 and Its Role in Obesity

Obesity Reviews, EarlyView.
ABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Nahuel Garcia, Maiken Mellergaard, Carlos Salomon, Pilar Sepulveda, Peter Kristensen, Aase Handberg   +5 more
wiley   +1 more source

Restoring metabolic flexibility: targeting organelle interaction networks in the pathogenesis and therapy of MASLD. [PDF]

Front Cell Dev Biol
Liu Y, Wang Y, Zhou J, Li H, Liu C, Zhong B, Liu J, Liu L, Zhang L, Sun L.   +9 more
europepmc   +1 more source

Effector‐Mediated Spatial Reprogramming of Glycolate Oxidase Subverts Peroxisomal and Membrane‐Associated ROS Defences

Plant Biotechnology Journal, EarlyView.
ABSTRACT Oomycete pathogens secrete hundreds of RXLR effectors into plant cells to modulate host immunity by targeting diverse plant proteins. Here, we report that the Peronophythora litchii RXLR effector PlAvh133 acts as a virulence factor and targets the litchi glycolate oxidase (GLO) LcGLO1, a key enzyme in photorespiration, thereby suppressing ...
Junjian Situ, Zijing Zhang, Yi Shao, Jiaying Feng, Feiteng Zhong, Muran Xiong, Wen Li, Peng Li, Xiaofan Zhou, Guibing Hu, Jietang Zhao, Minhui Li, Pinggen Xi, Xinxiang Peng, Zide Jiang, Guanghui Kong   +15 more
wiley   +1 more source

A Bacterial Effector Hijacks NBR1 to Modulate Both Autophagy and Ubiquitination‐Mediated Degradation That Promotes Bacterial Infection

Plant Biotechnology Journal, EarlyView.
ABSTRACT Autophagy and the ubiquitin/26S proteasome system (UPS) play critical roles in the immune defence of the host against pathogen invasion. As a countermeasure, pathogens deploy effector proteins to subvert or hijack autophagy and UPS processes.
Yaqian Shi, Fang Fang, Xuejin Cui, Hongwei Shi, Zaiyu Yang, Xueyi Li, Changyong Zhou, Xuefeng Wang   +7 more
wiley   +1 more source